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Ovarian Stromal Hyperplasia

MedGen UID:
275295
•Concept ID:
C1518742
•
Disease or Syndrome

Definition

A non-neoplastic disorder that usually affects postmenopausal women. It is characterized by proliferation of ovarian stromal cells without evidence of atypia. There is usually bilateral ovarian involvement. The ovaries may or may not be enlarged. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOvarian Stromal Hyperplasia

Professional guidelines

PubMed

Androgen excess in breast cancer development: implications for prevention and treatment.
Secreto G, Girombelli A, Krogh V
Endocr Relat Cancer 2019 Feb;26(2):R81-R94. doi: 10.1530/ERC-18-0429. PMID: 30403656
Differential diagnosis of gynecologic organ-related diseases in women presenting with ascites.
Cheng MH, Yen MS, Chao KC, Sheu BC, Wang PH
Taiwan J Obstet Gynecol 2008 Dec;47(4):384-90. doi: 10.1016/S1028-4559(09)60003-6. PMID: 19126502

Recent clinical studies

Etiology

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.
Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system.
Mok ZW, Chin JPS
BMJ Case Rep 2022 Dec 21;15(12) doi: 10.1136/bcr-2022-252391. PMID: 36543369Free PMC Article
Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma.
Reijnen C, Küsters-Vandevelde HVN, Abbink K, Zusterzeel PLM, van Herwaarden AE, van der Laak JAWM, Massuger LFAG, Snijders MPLM, Pijnenborg JMA, Bulten J
Hum Pathol 2019 Mar;85:119-127. Epub 2018 Nov 11 doi: 10.1016/j.humpath.2018.10.022. PMID: 30428390
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Burkadze G, Sabakhtarashvili M
Georgian Med News 2006 Feb;(131):33-7. PMID: 16575127
Ovarian stromal hyperplasia and ovarian vein steroid levels in relation to endometrioid endometrial cancer.
Jongen VH, Hollema H, van der Zee AG, Santema JG, Heineman MJ
BJOG 2003 Jul;110(7):690-5. PMID: 12842061

Diagnosis

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.
Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Magnetic resonance imaging appearance of ovarian stromal hyperplasia and ovarian hyperthecosis.
Rosenkrantz AB, Popiolek D, Bennett GL, Hecht EM
J Comput Assist Tomogr 2009 Nov-Dec;33(6):912-6. doi: 10.1097/RCT.0b013e3181a2ec0c. PMID: 19940659
Cell adhesion and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Burkadze G, Sabakhtarashvili M
Georgian Med News 2006 Feb;(131):33-7. PMID: 16575127
Proliferation and apoptosis in ovarian stromal hyperplasia and hyperthecosis.
Sharabidze N, Sabakhtarashvili M, Burkadze G
Georgian Med News 2005 Dec;(129):26-9. PMID: 16444023
Bilateral ovarian stromal hyperplasia concealing a nonhilar, pure stromal-Leydig cell tumor. A case report.
Oler A, Singh M, Ural SH
J Reprod Med 1999 Jun;44(6):563-6. PMID: 10394554

Therapy

Rare case of coexisting ovarian Brenner tumour and ovarian stromal hyperplasia presenting with persistent endometrial hyperplasia following treatment with levonorgestrel-intrauterine system.
Mok ZW, Chin JPS
BMJ Case Rep 2022 Dec 21;15(12) doi: 10.1136/bcr-2022-252391. PMID: 36543369Free PMC Article
Androgen excess in breast cancer development: implications for prevention and treatment.
Secreto G, Girombelli A, Krogh V
Endocr Relat Cancer 2019 Feb;26(2):R81-R94. doi: 10.1530/ERC-18-0429. PMID: 30403656
Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology.
Ikeda K, Baba T, Noguchi H, Nagasawa K, Endo T, Kiya T, Saito T
Hum Reprod 2013 Feb;28(2):453-61. Epub 2012 Nov 27 doi: 10.1093/humrep/des385. PMID: 23188113
Ovarian volume: determinants and associations with cancer among postmenopausal women.
Sherman ME, Lacey JV, Buys SS, Reding DJ, Berg CD, Williams C, Hartge P
Cancer Epidemiol Biomarkers Prev 2006 Aug;15(8):1550-4. doi: 10.1158/1055-9965.EPI-05-0847. PMID: 16896048
A clinical and pathologic review of ovarian stromal hyperplasia and its possible relationship to common diseases of the female reproductive system.
Stearns HC, Sneeden VD, Fearl JD
Am J Obstet Gynecol 1974 Jun 1;119(3):375-81. doi: 10.1016/0002-9378(74)90297-x. PMID: 4827378

Prognosis

Ovarian Leydig Cell Tumor and Ovarian Hyperthecosis in a Postmenopausal Woman: A Case Report and Literature Review.
Bužinskienė D, Marčiukaitytė R, Šidlovska E, Rudaitis V
Medicina (Kaunas) 2023 Jun 6;59(6) doi: 10.3390/medicina59061097. PMID: 37374301Free PMC Article
Postmenopausal patients with endometrial cancer of type 1 have elevated serum estradiol levels in the ovarian vein.
Ashihara K, Tanaka T, Maruoka R, Ono YJ, Tanabe A, Terai Y, Ohmichi M
Int J Gynecol Cancer 2014 Oct;24(8):1455-60. doi: 10.1097/IGC.0000000000000227. PMID: 25078344
Ovarian volume assessment in relation to histologic findings and sex hormone levels in women with postmenopausal bleeding and thickened endometrium.
Elfayomy AK, El Tarhouny SA
Ann Saudi Med 2012 Nov-Dec;32(6):588-92. doi: 10.5144/0256-4947.2012.588. PMID: 23396021Free PMC Article
Partly luteinized theca cell tumor of the ovary.
Roth LM, Sternberg WH
Cancer 1983 May 1;51(9):1697-704. doi: 10.1002/1097-0142(19830501)51:9<1697::aid-cncr2820510923>3.0.co;2-3. PMID: 6299506

Clinical prediction guides

Quantification of Leydig cells and stromal hyperplasia in the postmenopausal ovary of women with endometrial carcinoma.
Reijnen C, Küsters-Vandevelde HVN, Abbink K, Zusterzeel PLM, van Herwaarden AE, van der Laak JAWM, Massuger LFAG, Snijders MPLM, Pijnenborg JMA, Bulten J
Hum Pathol 2019 Mar;85:119-127. Epub 2018 Nov 11 doi: 10.1016/j.humpath.2018.10.022. PMID: 30428390
Excessive androgen exposure in female-to-male transsexual persons of reproductive age induces hyperplasia of the ovarian cortex and stroma but not polycystic ovary morphology.
Ikeda K, Baba T, Noguchi H, Nagasawa K, Endo T, Kiya T, Saito T
Hum Reprod 2013 Feb;28(2):453-61. Epub 2012 Nov 27 doi: 10.1093/humrep/des385. PMID: 23188113
Ovarian volume assessment in relation to histologic findings and sex hormone levels in women with postmenopausal bleeding and thickened endometrium.
Elfayomy AK, El Tarhouny SA
Ann Saudi Med 2012 Nov-Dec;32(6):588-92. doi: 10.5144/0256-4947.2012.588. PMID: 23396021Free PMC Article
Morphometric assessment of ovarian stromal proliferation--a clinicopathological study.
Snowden JA, Harkin PJ, Thornton JG, Wells M
Histopathology 1989 Apr;14(4):369-79. doi: 10.1111/j.1365-2559.1989.tb02165.x. PMID: 2737613
Alpha smooth muscle actin (alpha-SM actin) in normal human ovaries, in ovarian stromal hyperplasia and in ovarian neoplasms.
Czernobilsky B, Shezen E, Lifschitz-Mercer B, Fogel M, Luzon A, Jacob N, Skalli O, Gabbiani G
Virchows Arch B Cell Pathol Incl Mol Pathol 1989;57(1):55-61. doi: 10.1007/BF02899065. PMID: 2567550

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