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Ovarian Brenner tumor

MedGen UID:
1716777
•Concept ID:
C5234884
•
Neoplastic Process
Synonym: Brenner tumor of ovary
SNOMED CT: Brenner tumor of ovary (254859006)
 
Monarch Initiative: MONDO:0002370

Definition

A neoplasm that arises from the ovary and is composed of nests of neoplastic urothelial-type cells in a fibrotic stroma. It includes benign Brenner tumor, borderline Brenner tumor, and malignant Brenner tumor. [from NCI]

Professional guidelines

PubMed

A longitudinal single-cell atlas of anti-tumour necrosis factor treatment in inflammatory bowel disease.
Thomas T, Friedrich M, Rich-Griffin C, Pohin M, Agarwal D, Pakpoor J, Lee C, Tandon R, Rendek A, Aschenbrenner D, Jainarayanan A, Voda A, Siu JHY, Sanches-Peres R, Nee E, Sathananthan D, Kotliar D, Todd P, Kiourlappou M, Gartner L, Ilott N, Issa F, Hester J, Turner J, Nayar S, Mackerodt J, Zhang F, Jonsson A, Brenner M, Raychaudhuri S, Kulicke R, Ramsdell D, Stransky N, Pagliarini R, Bielecki P, Spies N, Marsden B, Taylor S, Wagner A, Klenerman P, Walsh A, Coles M, Jostins-Dean L, Powrie FM, Filer A, Travis S, Uhlig HH, Dendrou CA, Buckley CD
Nat Immunol 2024 Nov;25(11):2152-2165. Epub 2024 Oct 22 doi: 10.1038/s41590-024-01994-8. PMID: 39438660Free PMC Article
Lessons from characterization and treatment of the autoinflammatory syndromes.
Aksentijevich I, McDermott MF
Curr Opin Rheumatol 2017 Mar;29(2):187-194. doi: 10.1097/BOR.0000000000000362. PMID: 27906774Free PMC Article
No clinical utility of KRAS variant rs61764370 for ovarian or breast cancer.
Ovarian Cancer Association Consortium, Breast Cancer Association Consortium, and Consortium of Modifiers of BRCA1 and BRCA2, Hollestelle A, van der Baan FH, Berchuck A, Johnatty SE, Aben KK, Agnarsson BA, Aittomäki K, Alducci E, Andrulis IL, Anton-Culver H, Antonenkova NN, Antoniou AC, Apicella C, Arndt V, Arnold N, Arun BK, Arver B, Ashworth A; Australian Ovarian Cancer Study Group, Baglietto L, Balleine R, Bandera EV, Barrowdale D, Bean YT, Beckmann L, Beckmann MW, Benitez J, Berger A, Berger R, Beuselinck B, Bisogna M, Bjorge L, Blomqvist C, Bogdanova NV, Bojesen A, Bojesen SE, Bolla MK, Bonanni B, Brand JS, Brauch H; Breast Cancer Family Register, Brenner H, Brinton L, Brooks-Wilson A, Bruinsma F, Brunet J, Brüning T, Budzilowska A, Bunker CH, Burwinkel B, Butzow R, Buys SS, Caligo MA, Campbell I, Carter J, Chang-Claude J, Chanock SJ, Claes KBM, Collée JM, Cook LS, Couch FJ, Cox A, Cramer D, Cross SS, Cunningham JM, Cybulski C, Czene K, Damiola F, Dansonka-Mieszkowska A, Darabi H, de la Hoya M, deFazio A, Dennis J, Devilee P, Dicks EM, Diez O, Doherty JA, Domchek SM, Dorfling CM, Dörk T, Silva IDS, du Bois A, Dumont M, Dunning AM, Duran M, Easton DF, Eccles D, Edwards RP, Ehrencrona H, Ejlertsen B, Ekici AB, Ellis SD; EMBRACE, Engel C, Eriksson M, Fasching PA, Feliubadalo L, Figueroa J, Flesch-Janys D, Fletcher O, Fontaine A, Fortuzzi S, Fostira F, Fridley BL, Friebel T, Friedman E, Friel G, Frost D, Garber J, García-Closas M, Gayther SA; GEMO Study Collaborators; GENICA Network, Gentry-Maharaj A, Gerdes AM, Giles GG, Glasspool R, Glendon G, Godwin AK, Goodman MT, Gore M, Greene MH, Grip M, Gronwald J, Gschwantler Kaulich D, Guénel P, Guzman SR, Haeberle L, Haiman CA, Hall P, Halverson SL, Hamann U, Hansen TVO, Harter P, Hartikainen JM, Healey S; HEBON, Hein A, Heitz F, Henderson BE, Herzog J, T Hildebrandt MA, Høgdall CK, Høgdall E, Hogervorst FBL, Hopper JL, Humphreys K, Huzarski T, Imyanitov EN, Isaacs C, Jakubowska A, Janavicius R, Jaworska K, Jensen A, Jensen UB, Johnson N, Jukkola-Vuorinen A, Kabisch M, Karlan BY, Kataja V, Kauff N; KConFab Investigators, Kelemen LE, Kerin MJ, Kiemeney LA, Kjaer SK, Knight JA, Knol-Bout JP, Konstantopoulou I, Kosma VM, Krakstad C, Kristensen V, Kuchenbaecker KB, Kupryjanczyk J, Laitman Y, Lambrechts D, Lambrechts S, Larson MC, Lasa A, Laurent-Puig P, Lazaro C, Le ND, Le Marchand L, Leminen A, Lester J, Levine DA, Li J, Liang D, Lindblom A, Lindor N, Lissowska J, Long J, Lu KH, Lubinski J, Lundvall L, Lurie G, Mai PL, Mannermaa A, Margolin S, Mariette F, Marme F, Martens JWM, Massuger LFAG, Maugard C, Mazoyer S, McGuffog L, McGuire V, McLean C, McNeish I, Meindl A, Menegaux F, Menéndez P, Menkiszak J, Menon U, Mensenkamp AR, Miller N, Milne RL, Modugno F, Montagna M, Moysich KB, Müller H, Mulligan AM, Muranen TA, Narod SA, Nathanson KL, Ness RB, Neuhausen SL, Nevanlinna H, Neven P, Nielsen FC, Nielsen SF, Nordestgaard BG, Nussbaum RL, Odunsi K, Offit K, Olah E, Olopade OI, Olson JE, Olson SH, Oosterwijk JC, Orlow I, Orr N, Orsulic S, Osorio A, Ottini L, Paul J, Pearce CL, Pedersen IS, Peissel B, Pejovic T, Pelttari LM, Perkins J, Permuth-Wey J, Peterlongo P, Peto J, Phelan CM, Phillips KA, Piedmonte M, Pike MC, Platte R, Plisiecka-Halasa J, Poole EM, Poppe B, Pylkäs K, Radice P, Ramus SJ, Rebbeck TR, Reed MWR, Rennert G, Risch HA, Robson M, Rodriguez GC, Romero A, Rossing MA, Rothstein JH, Rudolph A, Runnebaum I, Salani R, Salvesen HB, Sawyer EJ, Schildkraut JM, Schmidt MK, Schmutzler RK, Schneeweiss A, Schoemaker MJ, Schrauder MG, Schumacher F, Schwaab I, Scuvera G, Sellers TA, Severi G, Seynaeve CM, Shah M, Shrubsole M, Siddiqui N, Sieh W, Simard J, Singer CF, Sinilnikova OM, Smeets D, Sohn C, Soller M, Song H, Soucy P, Southey MC, Stegmaier C, Stoppa-Lyonnet D, Sucheston L; SWE-BRCA, Swerdlow A, Tangen IL, Tea MK, Teixeira MR, Terry KL, Terry MB, Thomassen M, Thompson PJ, Tihomirova L, Tischkowitz M, Toland AE, Tollenaar RAEM, Tomlinson I, Torres D, Truong T, Tsimiklis H, Tung N, Tworoger SS, Tyrer JP, Vachon CM, Van 't Veer LJ, van Altena AM, Van Asperen CJ, van den Berg D, van den Ouweland AMW, van Doorn HC, Van Nieuwenhuysen E, van Rensburg EJ, Vergote I, Verhoef S, Vierkant RA, Vijai J, Vitonis AF, von Wachenfeldt A, Walsh C, Wang Q, Wang-Gohrke S, Wappenschmidt B, Weischer M, Weitzel JN, Weltens C, Wentzensen N, Whittemore AS, Wilkens LR, Winqvist R, Wu AH, Wu X, Yang HP, Zaffaroni D, Pilar Zamora M, Zheng W, Ziogas A, Chenevix-Trench G, Pharoah PDP, Rookus MA, Hooning MJ, Goode EL
Gynecol Oncol 2016 May;141(2):386-401. Epub 2015 May 2 doi: 10.1016/j.ygyno.2015.04.034. PMID: 25940428Free PMC Article

Recent clinical studies

Etiology

A report of twenty cases of ovarian Brenner tumor and literature review: a case series study.
Lou Z, Mei L, Wan Z, Zhang W, Gao J
BMC Womens Health 2024 Aug 27;24(1):471. doi: 10.1186/s12905-024-03316-4. PMID: 39192213Free PMC Article
Different staining patterns of ovarian Brenner tumor and the associated mucinous tumor.
Roma AA, Masand RP
Ann Diagn Pathol 2015 Feb;19(1):29-32. Epub 2014 Dec 20 doi: 10.1016/j.anndiagpath.2014.12.002. PMID: 25596159
Management and prognosis of borderline ovarian Brenner tumors.
Uzan C, Dufeu-Lefebvre M, Fauvet R, Gouy S, Duvillard P, Darai E, Morice P
Int J Gynecol Cancer 2012 Oct;22(8):1332-6. doi: 10.1097/IGC.0b013e318267db2f. PMID: 22954784
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use.
Bristow RE, Montz FJ
Int J Gynecol Cancer 2001 Jul-Aug;11(4):312-5. doi: 10.1046/j.1525-1438.2001.011004312.x. PMID: 11520371

Diagnosis

A report of twenty cases of ovarian Brenner tumor and literature review: a case series study.
Lou Z, Mei L, Wan Z, Zhang W, Gao J
BMC Womens Health 2024 Aug 27;24(1):471. doi: 10.1186/s12905-024-03316-4. PMID: 39192213Free PMC Article
A Rare Case of Ruptured Malignant Ovarian Brenner Tumor.
Kurniadi A, Anfasa MK, Agustina H, Dewayani BM, Kireina J
Am J Case Rep 2023 Feb 13;24:e938680. doi: 10.12659/AJCR.938680. PMID: 36775948Free PMC Article
Borderline Brenner tumor with abnormally high serum level of carbohydrate antigen 199: a rare case report and literature review.
Yu Q, Zhao Q, Su Y, Xiong K, Lu Y, Zhang L, Fang H
Ir J Med Sci 2023 Oct;192(5):2071-2075. Epub 2022 Nov 21 doi: 10.1007/s11845-022-03203-7. PMID: 36409423
Tumor to Tumor Metastasis: A Case Report of Metastatic Angiosarcoma to an Ovarian Brenner Tumor and Review of the Literature.
Dundar B, Alrwashdeh A, Dahmoush L
Int J Gynecol Pathol 2023 Mar 1;42(2):176-181. Epub 2022 Mar 11 doi: 10.1097/PGP.0000000000000854. PMID: 35283447
FDG PET/CT of a benign ovarian Brenner tumor.
Toriihara A, Taniguchi Y, Negi M, Kubota K, Makino T, Shibuya H
Clin Imaging 2012 Sep-Oct;36(5):650-3. Epub 2012 Jun 8 doi: 10.1016/j.clinimag.2011.12.018. PMID: 22920385

Therapy

A report of twenty cases of ovarian Brenner tumor and literature review: a case series study.
Lou Z, Mei L, Wan Z, Zhang W, Gao J
BMC Womens Health 2024 Aug 27;24(1):471. doi: 10.1186/s12905-024-03316-4. PMID: 39192213Free PMC Article
Leiomyomatosis peritonealis disseminata and ovarian Brenner tumor associated with tamoxifen use.
Bristow RE, Montz FJ
Int J Gynecol Cancer 2001 Jul-Aug;11(4):312-5. doi: 10.1046/j.1525-1438.2001.011004312.x. PMID: 11520371

Prognosis

A peculiar case report of extraovarian Brenner tumor arising in the omentum.
Hwang CS, Lee CH, Lee SJ, Kim YG, Kim A, Park DY, Kang HJ, Shin DH
World J Surg Oncol 2017 Mar 28;15(1):72. doi: 10.1186/s12957-017-1135-2. PMID: 28351362Free PMC Article
Management and prognosis of borderline ovarian Brenner tumors.
Uzan C, Dufeu-Lefebvre M, Fauvet R, Gouy S, Duvillard P, Darai E, Morice P
Int J Gynecol Cancer 2012 Oct;22(8):1332-6. doi: 10.1097/IGC.0b013e318267db2f. PMID: 22954784

Clinical prediction guides

Management and prognosis of borderline ovarian Brenner tumors.
Uzan C, Dufeu-Lefebvre M, Fauvet R, Gouy S, Duvillard P, Darai E, Morice P
Int J Gynecol Cancer 2012 Oct;22(8):1332-6. doi: 10.1097/IGC.0b013e318267db2f. PMID: 22954784
FDG PET/CT of a benign ovarian Brenner tumor.
Toriihara A, Taniguchi Y, Negi M, Kubota K, Makino T, Shibuya H
Clin Imaging 2012 Sep-Oct;36(5):650-3. Epub 2012 Jun 8 doi: 10.1016/j.clinimag.2011.12.018. PMID: 22920385
Immunohistochemical analysis of uroplakins, urothelial specific proteins, in ovarian Brenner tumors, normal tissues, and benign and neoplastic lesions of the female genital tract.
Ogawa K, Johansson SL, Cohen SM
Am J Pathol 1999 Oct;155(4):1047-50. doi: 10.1016/S0002-9440(10)65206-6. PMID: 10514386Free PMC Article
Brenner tumor of the ovary: immunoanalysis of steroidogenic enzymes in 23 cases.
Sasano H, Wargotz ES, Silverberg SG, Mason JI, Simpson ER
Hum Pathol 1989 Nov;20(11):1103-7. doi: 10.1016/0046-8177(89)90230-x. PMID: 2807272

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