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Advanced Digestive System Carcinoma

MedGen UID:: 1668637
•Concept ID:: C4745037
•: Neoplastic Process

Definition

Digestive system carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAdvanced Digestive System Carcinoma

Neoplasm
- Neoplasm by Special Category
  - Metastatic neoplasm
    - Metastatic malignant neoplasm
      - Advanced Malignant Neoplasm
        Advanced Carcinoma
        Advanced Digestive System Carcinoma
        Advanced Anal Carcinoma
        Advanced Anal Canal Squamous Cell Carcinoma
        Advanced Colorectal Carcinoma
        Advanced Colon Carcinoma
        Advanced Colon Adenocarcinoma
        Advanced Colorectal Adenocarcinoma
        Advanced Rectal Adenocarcinoma
        Advanced Microsatellite Stable Colorectal Carcinoma
        Advanced Rectal Carcinoma
        Advanced Rectal Squamous Cell Carcinoma
        Advanced Esophageal Carcinoma
        Advanced Esophageal Adenocarcinoma
        Advanced Esophageal Squamous Cell Carcinoma
        Advanced Gastric Carcinoma
        Advanced Gastric Adenocarcinoma
        Advanced Unresectable Gastric Adenocarcinoma
        Advanced Gastric Neuroendocrine Carcinoma
        Advanced Gastric Large Cell Neuroendocrine Carcinoma
        Advanced Gastric Small Cell Neuroendocrine Carcinoma
        Advanced Gastroesophageal Junction Adenocarcinoma
        Advanced Hepatocellular Carcinoma
        Advanced Adult Hepatocellular Carcinoma
        Advanced Pancreatobiliary Carcinoma
        Advanced Ampulla of Vater Carcinoma
        Advanced Biliary Tract Carcinoma
        Advanced Bile Duct Carcinoma
        Advanced Gallbladder Carcinoma
        Advanced Pancreatic Carcinoma
        Advanced Pancreatic Adenocarcinoma
        Advanced Small Intestinal Neuroendocrine Carcinoma
        Advanced Small Intestinal Large Cell Neuroendocrine Carcinoma
        Advanced Small Intestinal Small Cell Neuroendocrine Carcinoma

Professional guidelines

PubMed

Advances in the treatment of intrahepatic cholangiocarcinoma: An overview of the current and future therapeutic landscape for clinicians.

Moris D, Palta M, Kim C, Allen PJ, Morse MA, Lidsky ME
CA Cancer J Clin 2023 Mar;73(2):198-222. Epub 2022 Oct 19 doi: 10.3322/caac.21759. PMID: 36260350

Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.

McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695 Free PMC Article

Pathogenesis, diagnosis, and management of cholangiocarcinoma.

Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396 Free PMC Article

See all (642)

Recent clinical studies

Etiology

Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions.

Macias RIR, Cardinale V, Kendall TJ, Avila MA, Guido M, Coulouarn C, Braconi C, Frampton AE, Bridgewater J, Overi D, Pereira SP, Rengo M, Kather JN, Lamarca A, Pedica F, Forner A, Valle JW, Gaudio E, Alvaro D, Banales JM, Carpino G
Gut 2022 Aug;71(8):1669-1683. Epub 2022 May 17 doi: 10.1136/gutjnl-2022-327099. PMID: 35580963

Immunotherapy in cholangiocarcinoma.

Al-Rajabi R, Sun W
Curr Opin Gastroenterol 2021 Mar 1;37(2):105-111. doi: 10.1097/MOG.0000000000000715. PMID: 33507028

Esophagus and Gastrointestinal Junction Tumors.

Kurtom S, Kaplan BJ
Surg Clin North Am 2020 Jun;100(3):507-521. Epub 2020 Apr 11 doi: 10.1016/j.suc.2020.02.003. PMID: 32402297

Pediatric hepatocellular carcinoma.

Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403 Free PMC Article

Liver cirrhosis.

Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931 Free PMC Article

See all (3745)

Diagnosis

Advances in immunotherapy for biliary tract cancers.

Zhao Y, Yang M, Feng J, Wang X, Liu Y
Chin Med J (Engl) 2024 Mar 5;137(5):524-532. Epub 2023 Aug 29 doi: 10.1097/CM9.0000000000002759. PMID: 37646139 Free PMC Article

Clinical relevance of biomarkers in cholangiocarcinoma: critical revision and future directions.

Esophageal Cancer.

Alsop BR, Sharma P
Gastroenterol Clin North Am 2016 Sep;45(3):399-412. doi: 10.1016/j.gtc.2016.04.001. PMID: 27546839

Intrahepatic cholangiocarcinoma.

Brown KM, Parmar AD, Geller DA
Surg Oncol Clin N Am 2014 Apr;23(2):231-46. doi: 10.1016/j.soc.2013.10.004. PMID: 24560108 Free PMC Article

Liver cirrhosis.

Schuppan D, Afdhal NH
Lancet 2008 Mar 8;371(9615):838-51. doi: 10.1016/S0140-6736(08)60383-9. PMID: 18328931 Free PMC Article

See all (2791)

Therapy

Immune checkpoint inhibitors in hepatocellular carcinoma: emerging challenges in clinical practice.

Pinter M, Scheiner B, Pinato DJ
Lancet Gastroenterol Hepatol 2023 Aug;8(8):760-770. Epub 2023 Jun 14 doi: 10.1016/S2468-1253(23)00147-4. PMID: 37327807

Immunotherapy in Biliary Tract Cancers: Where Are We?

Kalyan A, Khosla H, Kim RD
Curr Oncol Rep 2022 Dec;24(12):1821-1828. Epub 2022 Oct 4 doi: 10.1007/s11912-022-01328-7. PMID: 36192517

Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.

Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550 Free PMC Article

Pediatric hepatocellular carcinoma.

Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403 Free PMC Article

Oesophageal cancer.

Smyth EC, Lagergren J, Fitzgerald RC, Lordick F, Shah MA, Lagergren P, Cunningham D
Nat Rev Dis Primers 2017 Jul 27;3:17048. doi: 10.1038/nrdp.2017.48. PMID: 28748917 Free PMC Article

See all (2433)

Prognosis

Cholangiocarcinoma: Epidemiology and risk factors.

Khan SA, Tavolari S, Brandi G
Liver Int 2019 May;39 Suppl 1:19-31. Epub 2019 Mar 24 doi: 10.1111/liv.14095. PMID: 30851228

KEYNOTE-590: Phase III study of first-line chemotherapy with or without pembrolizumab for advanced esophageal cancer.

Kato K, Shah MA, Enzinger P, Bennouna J, Shen L, Adenis A, Sun JM, Cho BC, Özgüroğlu M, Kojima T, Kostorov V, Hierro C, Zhu Y, McLean LA, Shah S, Doi T
Future Oncol 2019 Apr;15(10):1057-1066. Epub 2019 Feb 8 doi: 10.2217/fon-2018-0609. PMID: 30735435

Pediatric hepatocellular carcinoma.

Khanna R, Verma SK
World J Gastroenterol 2018 Sep 21;24(35):3980-3999. doi: 10.3748/wjg.v24.i35.3980. PMID: 30254403 Free PMC Article

Oesophageal cancer.

Smyth EC, Lagergren J, Fitzgerald RC, Lordick F, Shah MA, Lagergren P, Cunningham D
Nat Rev Dis Primers 2017 Jul 27;3:17048. doi: 10.1038/nrdp.2017.48. PMID: 28748917 Free PMC Article

Esophageal Cancer.

Alsop BR, Sharma P
Gastroenterol Clin North Am 2016 Sep;45(3):399-412. doi: 10.1016/j.gtc.2016.04.001. PMID: 27546839

See all (3532)

Clinical prediction guides

Liver transplantation for intrahepatic cholangiocarcinoma: a propensity score-matched analysis.

Huang G, Song W, Zhang Y, Yu J, Lv Y, Liu K
Sci Rep 2023 Jun 30;13(1):10630. doi: 10.1038/s41598-023-37896-2. PMID: 37391482 Free PMC Article

Steatosis, Steatohepatitis and Cancer Immunotherapy: An Intricate Story.

Cataldi M, Manco F, Tarantino G
Int J Mol Sci 2021 Nov 30;22(23) doi: 10.3390/ijms222312947. PMID: 34884762 Free PMC Article

Tumor Immune Microenvironment and Immunosuppressive Therapy in Hepatocellular Carcinoma: A Review.

Oura K, Morishita A, Tani J, Masaki T
Int J Mol Sci 2021 May 28;22(11) doi: 10.3390/ijms22115801. PMID: 34071550 Free PMC Article

Evolving management of metaplasia and dysplasia in Barrett's epithelium.

Evans RP, Mourad MM, Fisher SG, Bramhall SR
World J Gastroenterol 2016 Dec 21;22(47):10316-10324. doi: 10.3748/wjg.v22.i47.10316. PMID: 28058012 Free PMC Article

Gallbladder carcinoma: radiologic-pathologic correlation.

Levy AD, Murakata LA, Rohrmann CA Jr
Radiographics 2001 Mar-Apr;21(2):295-314; questionnaire, 549-55. doi: 10.1148/radiographics.21.2.g01mr16295. PMID: 11259693

See all (2359)

Recent systematic reviews

Efficacy and safety of Zolbetuximab plus chemotherapy for advanced CLDN18.2-positive gastric or gastro-oesophageal adenocarcinoma: a meta-analysis of randomized clinical trials.

de Moraes FCA, Pasqualotto E, Chavez MP, Ferreira ROM, De Castria TB, Burbano RMR
BMC Cancer 2024 Feb 21;24(1):240. doi: 10.1186/s12885-024-11980-w. PMID: 38383390 Free PMC Article

Immunotherapy and Targeted Therapy for Advanced Gastroesophageal Cancer: ASCO Guideline.

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169

Systematic review: radiomics for the diagnosis and prognosis of hepatocellular carcinoma.

Harding-Theobald E, Louissaint J, Maraj B, Cuaresma E, Townsend W, Mendiratta-Lala M, Singal AG, Su GL, Lok AS, Parikh ND
Aliment Pharmacol Ther 2021 Oct;54(7):890-901. Epub 2021 Aug 12 doi: 10.1111/apt.16563. PMID: 34390014 Free PMC Article

Nonalcoholic fatty liver disease: a systematic review.

Rinella ME
JAMA 2015 Jun 9;313(22):2263-73. doi: 10.1001/jama.2015.5370. PMID: 26057287

Adjuvant chemotherapy for small intestine adenocarcinoma.

Singhal N, Singhal D
Cochrane Database Syst Rev 2007 Jul 18;2007(3):CD005202. doi: 10.1002/14651858.CD005202.pub2. PMID: 17636789 Free PMC Article

See all (87)

MedGen

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Advanced Digestive System Carcinoma

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

Recent activity