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Advanced Colorectal Adenocarcinoma

MedGen UID:
1719745
•Concept ID:
C5237826
•
Neoplastic Process

Definition

Colorectal adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Colorectal Adenocarcinoma

Professional guidelines

PubMed

Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil.
Nozue M, Isaka N, Maruyama T, Kawamoto T, Seino KI, Tanagichi H, Fukao K
Oncol Rep 2002 Jan-Feb;9(1):93-6. PMID: 11748463
Long-term ambulatory treatment of metastatic colorectal adenocarcinoma by continuous intravenous infusion of 5-fluorouracil.
Quebbeman E, Ausman R, Hansen R, Becker T, Caballero G, Ritch P, Jenkins D, Blake D, Tangen L, Schulte W
J Surg Oncol 1985 Sep;30(1):60-5. doi: 10.1002/jso.2930300115. PMID: 3935873
Treatment of advanced colorectal and gastric adenocarcinomas with 5-fluorouracil combined with high-dose folinic acid. An update.
Machover D, Goldschmidt E, Schwarzenberg L, Vanden-Bulcke JM, Misset JL, Chollet P, Mathé G
Chemioterapia 1985 Oct;4(5):369-76. PMID: 3878231

Recent clinical studies

Etiology

Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients.
Zhu W, Wu C, Hu S, Liu S, Zhao S, Zhang D, Qiu G, Cheng X, Huang J
Sci Rep 2023 Dec 4;13(1):21358. doi: 10.1038/s41598-023-48623-2. PMID: 38049474Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
Yao HP, Tong XM, Hudson R, Wang MH
J Exp Clin Cancer Res 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x. PMID: 32962738Free PMC Article
Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma.
Ştefănescu D, Streba C, Cârţână ET, Săftoiu A, Gruionu G, Gruionu LG
PLoS One 2016;11(5):e0154863. Epub 2016 May 4 doi: 10.1371/journal.pone.0154863. PMID: 27144985Free PMC Article
Angiogenesis in advanced colorectal adenocarcinoma with special reference to tumoral invasion.
Tarta C, Teixeira CR, Tanaka S, Haruma K, Chiele-Neto C, da Silva VD
Arq Gastroenterol 2002 Jan-Mar;39(1):32-8. doi: 10.1590/s0004-28032002000100007. PMID: 12184164

Diagnosis

RAS Mutational Status in Advanced Colorectal Adenocarcinoma Treated With Anti-angiogenics: Preliminary Experience With Liquid Biopsy.
DE Santiago BG, López-Gómez M, Delgado-López PD, Gordo AJ, Neria F, Thuissard-Vasallo IJ, Gómez-Raposo C, Tevar FZ, Moreno-Rubio J, Hernández AM, Iglesias I, Casado E
In Vivo 2021 Sep-Oct;35(5):2841-2844. doi: 10.21873/invivo.12571. PMID: 34410976Free PMC Article
Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials.
Schperberg AV, Boichard A, Tsigelny IF, Richard SB, Kurzrock R
Int J Cancer 2020 Nov 1;147(9):2537-2549. Epub 2020 Aug 19 doi: 10.1002/ijc.33240. PMID: 32745254
Primary adenocarcinoma of the bladder lacks mismatch repair deficiency and demonstrates PD-L1 expression in tumor-infiltrating immune cells, with implications in both diagnosis and therapeutics.
Jones D, Guan JJ, Calagua C, Hansel DE, Epstein JI, Ye H
Hum Pathol 2019 Dec;94:58-63. Epub 2019 Oct 27 doi: 10.1016/j.humpath.2019.10.005. PMID: 31666198
Computer Aided Diagnosis for Confocal Laser Endomicroscopy in Advanced Colorectal Adenocarcinoma.
Ştefănescu D, Streba C, Cârţână ET, Săftoiu A, Gruionu G, Gruionu LG
PLoS One 2016;11(5):e0154863. Epub 2016 May 4 doi: 10.1371/journal.pone.0154863. PMID: 27144985Free PMC Article
Treatment of advanced colorectal adenocarcinoma with weekly high-dose l-leucovorin and 5-fluorouracil.
Nozue M, Isaka N, Maruyama T, Kawamoto T, Seino KI, Tanagichi H, Fukao K
Oncol Rep 2002 Jan-Feb;9(1):93-6. PMID: 11748463

Therapy

TAS-102, Irinotecan, and bevacizumab in pre-treated metastatic colorectal cancer (TABAsCO), a phase II clinical trial.
Boland PM, Mukherjee S, Imanirad I, Vijayvergia N, Cohen SD, Gupta M, Iyer RV, Bakin A, Wang J, Chatley S, Cahill B, Vadehra D, Attwood K, Hochster HS, Fountzilas C
Br J Cancer 2024 Nov;131(8):1290-1297. Epub 2024 Sep 7 doi: 10.1038/s41416-024-02845-x. PMID: 39244627Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
RAS Mutational Status in Advanced Colorectal Adenocarcinoma Treated With Anti-angiogenics: Preliminary Experience With Liquid Biopsy.
DE Santiago BG, López-Gómez M, Delgado-López PD, Gordo AJ, Neria F, Thuissard-Vasallo IJ, Gómez-Raposo C, Tevar FZ, Moreno-Rubio J, Hernández AM, Iglesias I, Casado E
In Vivo 2021 Sep-Oct;35(5):2841-2844. doi: 10.21873/invivo.12571. PMID: 34410976Free PMC Article
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
Yao HP, Tong XM, Hudson R, Wang MH
J Exp Clin Cancer Res 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x. PMID: 32962738Free PMC Article
Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials.
Schperberg AV, Boichard A, Tsigelny IF, Richard SB, Kurzrock R
Int J Cancer 2020 Nov 1;147(9):2537-2549. Epub 2020 Aug 19 doi: 10.1002/ijc.33240. PMID: 32745254

Prognosis

Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients.
Zhu W, Wu C, Hu S, Liu S, Zhao S, Zhang D, Qiu G, Cheng X, Huang J
Sci Rep 2023 Dec 4;13(1):21358. doi: 10.1038/s41598-023-48623-2. PMID: 38049474Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
MET and RON receptor tyrosine kinases in colorectal adenocarcinoma: molecular features as drug targets and antibody-drug conjugates for therapy.
Yao HP, Tong XM, Hudson R, Wang MH
J Exp Clin Cancer Res 2020 Sep 22;39(1):198. doi: 10.1186/s13046-020-01711-x. PMID: 32962738Free PMC Article
Phosphorylation status of Akt and caspase-9 in gastric and colorectal carcinomas.
Sangawa A, Shintani M, Yamao N, Kamoshida S
Int J Clin Exp Pathol 2014;7(6):3312-7. Epub 2014 May 15 PMID: 25031754Free PMC Article
Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma.
Jain S, Singhal S, Francis F, Hajdu C, Wang JH, Suriawinata A, Wang YQ, Zhang M, Weinshel EH, Francois F, Pei ZH, Lee P, Xu RL
World J Gastroenterol 2011 Sep 21;17(35):3994-4000. doi: 10.3748/wjg.v17.i35.3994. PMID: 22046087Free PMC Article

Clinical prediction guides

Chemokine- and chemokine receptor-based signature predicts immunotherapy response in female colorectal adenocarcinoma patients.
Zhu W, Wu C, Hu S, Liu S, Zhao S, Zhang D, Qiu G, Cheng X, Huang J
Sci Rep 2023 Dec 4;13(1):21358. doi: 10.1038/s41598-023-48623-2. PMID: 38049474Free PMC Article
Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312
Machine learning model to predict oncologic outcomes for drugs in randomized clinical trials.
Schperberg AV, Boichard A, Tsigelny IF, Richard SB, Kurzrock R
Int J Cancer 2020 Nov 1;147(9):2537-2549. Epub 2020 Aug 19 doi: 10.1002/ijc.33240. PMID: 32745254
Identification of polymorphisms in ultraconserved elements associated with clinical outcomes in locally advanced colorectal adenocarcinoma.
Lin M, Eng C, Hawk ET, Huang M, Lin J, Gu J, Ellis LM, Wu X
Cancer 2012 Dec 15;118(24):6188-98. Epub 2012 Jun 6 doi: 10.1002/cncr.27653. PMID: 22673945Free PMC Article
Association of overexpression of TIF1γ with colorectal carcinogenesis and advanced colorectal adenocarcinoma.
Jain S, Singhal S, Francis F, Hajdu C, Wang JH, Suriawinata A, Wang YQ, Zhang M, Weinshel EH, Francois F, Pei ZH, Lee P, Xu RL
World J Gastroenterol 2011 Sep 21;17(35):3994-4000. doi: 10.3748/wjg.v17.i35.3994. PMID: 22046087Free PMC Article

Recent systematic reviews

Mucinous histology is associated with poor prognosis in locally advanced colorectal adenocarcinoma treated with postoperative first-line adjuvant chemotherapy: A systematic review and meta-analysis.
Zhang Y, Chen Y, Huang J, Wu X, Tang R, Huang Q, Xu Y, Peng X, Fu K, Xiao S
Eur J Surg Oncol 2022 Oct;48(10):2075-2081. Epub 2022 Jun 23 doi: 10.1016/j.ejso.2022.06.024. PMID: 35768312

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