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Advanced Ampulla of Vater Carcinoma

MedGen UID:
1730671
•Concept ID:
C5419085
•
Neoplastic Process

Definition

Carcinoma that arises from the ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Ampulla of Vater Carcinoma

Professional guidelines

PubMed

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Opportunities of improvement in the management of pancreatic and periampullary tumors.
Nordby T, Ikdahl T, Lothe IM, Ånonsen K, Hauge T, Edwin B, Line PD, Labori KJ, Buanes T
Scand J Gastroenterol 2013 May;48(5):617-25. doi: 10.3109/00365521.2013.781218. PMID: 23597153Free PMC Article

Recent clinical studies

Therapy

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.
Okano K, Oshima M, Suto H, Ando Y, Asano E, Kamada H, Kobara H, Masaki T, Suzuki Y
Surg Today 2022 Feb;52(2):189-197. Epub 2021 Apr 2 doi: 10.1007/s00595-021-02270-0. PMID: 33797636
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Insights and updates on endoscopic papillectomy.
Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873
Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539

Prognosis

Ampullary Adenocarcinoma, Version 1.2023, NCCN Clinical Practice Guidelines in Oncology.
Chiorean EG, Chiaro MD, Tempero MA, Malafa MP, Benson AB, Cardin DB, Christensen JA, Chung V, Czito B, Dillhoff M, Donahue TR, Dotan E, Fountzilas C, Glazer ES, Hardacre J, Hawkins WG, Klute K, Ko AH, Kunstman JW, LoConte N, Lowy AM, Masood A, Moravek C, Nakakura EK, Narang AK, Nardo L, Obando J, Polanco PM, Reddy S, Reyngold M, Scaife C, Shen J, Truty MJ, Vollmer C, Wolff RA, Wolpin BM, Rn BM, Lubin S, Darlow SD
J Natl Compr Canc Netw 2023 Jul;21(7):753-782. doi: 10.6004/jnccn.2023.0034. PMID: 37433437
Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.
Okano K, Oshima M, Suto H, Ando Y, Asano E, Kamada H, Kobara H, Masaki T, Suzuki Y
Surg Today 2022 Feb;52(2):189-197. Epub 2021 Apr 2 doi: 10.1007/s00595-021-02270-0. PMID: 33797636
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Ampullary carcinoma-A genetic perspective.
Jayaramayya K, Balachandar V, Santhy KS
Mutat Res Rev Mutat Res 2018 Apr-Jun;776:10-22. Epub 2018 Mar 17 doi: 10.1016/j.mrrev.2018.03.002. PMID: 29807574

Clinical prediction guides

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Ampullary carcinoma of the duodenum: current clinical issues and genomic overview.
Okano K, Oshima M, Suto H, Ando Y, Asano E, Kamada H, Kobara H, Masaki T, Suzuki Y
Surg Today 2022 Feb;52(2):189-197. Epub 2021 Apr 2 doi: 10.1007/s00595-021-02270-0. PMID: 33797636
Clinical and phenotypical characteristics of submucosal invasive carcinoma in non-ampullary duodenal cancer.
Matsueda K, Kanzaki H, Takenaka R, Nakagawa M, Matsueda K, Iwamuro M, Kawano S, Kawahara Y, Toji T, Tanaka T, Yagi T, Fujiwara T, Okada H
PLoS One 2021;16(8):e0256797. Epub 2021 Aug 27 doi: 10.1371/journal.pone.0256797. PMID: 34449813Free PMC Article
Adenocarcinoma of the ampulla of Vater: what treatment options are available?
Senatore FJ, Ynson ML, Dasanu CA
J Oncol Pharm Pract 2015 Oct;21(5):364-9. Epub 2014 Jun 5 doi: 10.1177/1078155214538086. PMID: 24906539

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720
Gemcitabine-based chemotherapy for advanced biliary tract carcinomas.
Abdel-Rahman O, Elsayed Z, Elhalawani H
Cochrane Database Syst Rev 2018 Apr 6;4(4):CD011746. doi: 10.1002/14651858.CD011746.pub2. PMID: 29624208Free PMC Article
Meta-analysis of adjuvant therapy following curative surgery for periampullary adenocarcinoma.
Acharya A, Markar SR, Sodergren MH, Malietzis G, Darzi A, Athanasiou T, Khan AZ
Br J Surg 2017 Jun;104(7):814-822. doi: 10.1002/bjs.10563. PMID: 28518410

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