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Advanced Small Intestinal Neuroendocrine Carcinoma

MedGen UID:
1651574
•Concept ID:
C4744988
•
Neoplastic Process

Definition

A small intestinal neuroendocrine carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Small Intestinal Neuroendocrine Carcinoma

Professional guidelines

PubMed

High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Recent clinical studies

Etiology

Clinicopathologic and Molecular Characterization of Inflammatory Bowel Disease-Associated Neuroendocrine Carcinomas and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.
Liao X, Schmidt AL, Zhang D, Li P, Wang X, Ko HM, Choi WT, Alpert L, Hao Y, Kovar-Peltz S, Polydorides AD, Wanjari P, Mastro J, Wang P
Mod Pathol 2024 Oct;37(10):100566. Epub 2024 Jul 16 doi: 10.1016/j.modpat.2024.100566. PMID: 39025404
Site-specific trends in gastroenteropancreatic neuroendocrine neoplasms in Bavaria, Germany.
Grundmann N, Voigtländer S, Hakimhashemi A, Pape UF, Meyer M, Müller-Nordhorn J
Cancer Med 2023 Oct;12(19):19949-19958. Epub 2023 Sep 22 doi: 10.1002/cam4.6510. PMID: 37737059Free PMC Article
Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article

Diagnosis

Clinicopathologic features and diagnostic challenges of small cluster pattern appendiceal neuroendocrine tumors.
Gertsen B, Arshi J, Li RX, Findeis-Hosey JJ, Huber AR, Hao Y
Ann Diagn Pathol 2024 Apr;69:152250. Epub 2023 Dec 20 doi: 10.1016/j.anndiagpath.2023.152250. PMID: 38142627
Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986

Therapy

Clinicopathologic and Molecular Characterization of Inflammatory Bowel Disease-Associated Neuroendocrine Carcinomas and Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms.
Liao X, Schmidt AL, Zhang D, Li P, Wang X, Ko HM, Choi WT, Alpert L, Hao Y, Kovar-Peltz S, Polydorides AD, Wanjari P, Mastro J, Wang P
Mod Pathol 2024 Oct;37(10):100566. Epub 2024 Jul 16 doi: 10.1016/j.modpat.2024.100566. PMID: 39025404
Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Surgical Principles in the Management of Small Bowel Neuroendocrine Tumors.
Gangi A, Anaya DA
Curr Treat Options Oncol 2020 Aug 29;21(11):88. doi: 10.1007/s11864-020-00784-2. PMID: 32862334
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009
Organ recipients suffering from undifferentiated neuroendocrine small-cell carcinoma of donor origin: a case report.
Foltys D, Linkermann A, Heumann A, Hoppe-Lotichius M, Heise M, Schad A, Schneider J, Bender K, Schmid M, Mauer D, Peixoto N, Otto G
Transplant Proc 2009 Jul-Aug;41(6):2639-42. doi: 10.1016/j.transproceed.2009.06.026. PMID: 19715991

Prognosis

Paclitaxel-carboplatin plus bevacizumab therapy for advanced neuroendocrine carcinoma of the uterine cervix: A retrospective case series.
Kotaka S, Kondo E, Kawai Y, Okamoto K, Kishigami Y, Yamawaki T, Nagao K, Toru H, Suzuki S
J Obstet Gynaecol Res 2023 Dec;49(12):2868-2874. Epub 2023 Sep 2 doi: 10.1111/jog.15783. PMID: 37658751
Primary small-cell neuroendocrine carcinoma of the bladder: Case report and literature review.
Olivieri V, Fortunati V, Bellei L, Massarelli M, Ruggiero G, Abate D, Serra N, Griffa D, Forte F, Corongiu E
Arch Ital Urol Androl 2020 Oct 2;92(3) doi: 10.4081/aiua.2020.3.211. PMID: 33016048
High-Grade Gastrointestinal Neuroendocrine Carcinoma Management and Outcomes: A National Cancer Database Study.
Alese OB, Jiang R, Shaib W, Wu C, Akce M, Behera M, El-Rayes BF
Oncologist 2019 Jul;24(7):911-920. Epub 2018 Nov 27 doi: 10.1634/theoncologist.2018-0382. PMID: 30482824Free PMC Article
Primary Biliary Mixed Adenoneuroendocrine Carcinoma (MANEC): A Short Review.
Acosta AM, Wiley EL
Arch Pathol Lab Med 2016 Oct;140(10):1157-62. doi: 10.5858/arpa.2015-0102-RS. PMID: 27684986
Heterogeneity of grade 3 gastroenteropancreatic neuroendocrine carcinomas: New insights and treatment implications.
Fazio N, Milione M
Cancer Treat Rev 2016 Nov;50:61-67. Epub 2016 Aug 28 doi: 10.1016/j.ctrv.2016.08.006. PMID: 27636009

Clinical prediction guides

Pediatric intestinal foregut and small bowel solid tumors: a review of 105 cases.
Zhuge Y, Cheung MC, Yang R, Eldick D, Koniaris LG, Sola JE
J Surg Res 2009 Sep;156(1):95-102. Epub 2009 May 3 doi: 10.1016/j.jss.2009.03.054. PMID: 19560163
How age changes the content of neuroendocrine peptides in the murine gastrointestinal tract.
El-Salhy M, Sandström O
Gerontology 1999 Jan-Feb;45(1):17-22. doi: 10.1159/000022050. PMID: 9852376

Recent systematic reviews

Management and outcomes of mixed adenoneuroendocrine carcinoma of the ampulla of Vater: A systematic review and pooled analysis of 56 patients.
Ziogas IA, Rallis KS, Tasoudis PT, Moris D, Schulick RD, Del Chiaro M
Eur J Surg Oncol 2023 Apr;49(4):682-687. Epub 2023 Jan 9 doi: 10.1016/j.ejso.2023.01.005. PMID: 36646615

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