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Advanced Hepatocellular Carcinoma

MedGen UID:
1719415
Concept ID:
C5238472
Neoplastic Process

Definition

Hepatocellular carcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Hepatocellular Carcinoma

Professional guidelines

PubMed

Yang X, Yang C, Zhang S, Geng H, Zhu AX, Bernards R, Qin W, Fan J, Wang C, Gao Q
Cancer Cell 2024 Feb 12;42(2):180-197. doi: 10.1016/j.ccell.2024.01.007. PMID: 38350421
Cappuyns S, Corbett V, Yarchoan M, Finn RS, Llovet JM
JAMA Oncol 2024 Mar 1;10(3):395-404. doi: 10.1001/jamaoncol.2023.2677. PMID: 37535375Free PMC Article
de Castria TB, Khalil DN, Harding JJ, O'Reilly EM, Abou-Alfa GK
Future Oncol 2022 Oct;18(33):3769-3782. Epub 2022 Nov 18 doi: 10.2217/fon-2022-0652. PMID: 36399155

Recent clinical studies

Etiology

Cappuyns S, Corbett V, Yarchoan M, Finn RS, Llovet JM
JAMA Oncol 2024 Mar 1;10(3):395-404. doi: 10.1001/jamaoncol.2023.2677. PMID: 37535375Free PMC Article
Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Abou-Alfa GK, Meyer T, Cheng AL, El-Khoueiry AB, Rimassa L, Ryoo BY, Cicin I, Merle P, Chen Y, Park JW, Blanc JF, Bolondi L, Klümpen HJ, Chan SL, Zagonel V, Pressiani T, Ryu MH, Venook AP, Hessel C, Borgman-Hagey AE, Schwab G, Kelley RK
N Engl J Med 2018 Jul 5;379(1):54-63. doi: 10.1056/NEJMoa1717002. PMID: 29972759Free PMC Article
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J; SHARP Investigators Study Group
N Engl J Med 2008 Jul 24;359(4):378-90. doi: 10.1056/NEJMoa0708857. PMID: 18650514

Diagnosis

Yang C, Zhang H, Zhang L, Zhu AX, Bernards R, Qin W, Wang C
Nat Rev Gastroenterol Hepatol 2023 Apr;20(4):203-222. Epub 2022 Nov 11 doi: 10.1038/s41575-022-00704-9. PMID: 36369487
Vogel A, Meyer T, Sapisochin G, Salem R, Saborowski A
Lancet 2022 Oct 15;400(10360):1345-1362. Epub 2022 Sep 6 doi: 10.1016/S0140-6736(22)01200-4. PMID: 36084663
Remash D, Prince DS, McKenzie C, Strasser SI, Kao S, Liu K
World J Gastroenterol 2021 Aug 28;27(32):5376-5391. doi: 10.3748/wjg.v27.i32.5376. PMID: 34539139Free PMC Article
Galle PR, Dufour JF, Peck-Radosavljevic M, Trojan J, Vogel A
Future Oncol 2021 Apr;17(10):1237-1251. Epub 2020 Dec 14 doi: 10.2217/fon-2020-0758. PMID: 33307782
Forner A, Reig M, Bruix J
Lancet 2018 Mar 31;391(10127):1301-1314. Epub 2018 Jan 5 doi: 10.1016/S0140-6736(18)30010-2. PMID: 29307467

Therapy

Rimassa L, Finn RS, Sangro B
J Hepatol 2023 Aug;79(2):506-515. Epub 2023 Mar 16 doi: 10.1016/j.jhep.2023.03.003. PMID: 36933770
Zhu AX, Abbas AR, de Galarreta MR, Guan Y, Lu S, Koeppen H, Zhang W, Hsu CH, He AR, Ryoo BY, Yau T, Kaseb AO, Burgoyne AM, Dayyani F, Spahn J, Verret W, Finn RS, Toh HC, Lujambio A, Wang Y
Nat Med 2022 Aug;28(8):1599-1611. Epub 2022 Jun 23 doi: 10.1038/s41591-022-01868-2. PMID: 35739268
Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Cheng AL, Qin S, Ikeda M, Galle PR, Ducreux M, Kim TY, Lim HY, Kudo M, Breder V, Merle P, Kaseb AO, Li D, Verret W, Ma N, Nicholas A, Wang Y, Li L, Zhu AX, Finn RS
J Hepatol 2022 Apr;76(4):862-873. Epub 2021 Dec 11 doi: 10.1016/j.jhep.2021.11.030. PMID: 34902530
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, de Oliveira AC, Santoro A, Raoul JL, Forner A, Schwartz M, Porta C, Zeuzem S, Bolondi L, Greten TF, Galle PR, Seitz JF, Borbath I, Häussinger D, Giannaris T, Shan M, Moscovici M, Voliotis D, Bruix J; SHARP Investigators Study Group
N Engl J Med 2008 Jul 24;359(4):378-90. doi: 10.1056/NEJMoa0708857. PMID: 18650514

Prognosis

Lai Z, He M, Bu X, Xu Y, Huang Y, Wen D, Li Q, Xu L, Zhang Y, Wei W, Chen M, Kan A, Shi M
Eur J Cancer 2022 Oct;174:68-77. Epub 2022 Aug 15 doi: 10.1016/j.ejca.2022.07.005. PMID: 35981413
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Zhu AX, Finn RS, Edeline J, Cattan S, Ogasawara S, Palmer D, Verslype C, Zagonel V, Fartoux L, Vogel A, Sarker D, Verset G, Chan SL, Knox J, Daniele B, Webber AL, Ebbinghaus SW, Ma J, Siegel AB, Cheng AL, Kudo M; KEYNOTE-224 investigators
Lancet Oncol 2018 Jul;19(7):940-952. Epub 2018 Jun 3 doi: 10.1016/S1470-2045(18)30351-6. PMID: 29875066
Kudo M, Finn RS, Qin S, Han KH, Ikeda K, Piscaglia F, Baron A, Park JW, Han G, Jassem J, Blanc JF, Vogel A, Komov D, Evans TRJ, Lopez C, Dutcus C, Guo M, Saito K, Kraljevic S, Tamai T, Ren M, Cheng AL
Lancet 2018 Mar 24;391(10126):1163-1173. doi: 10.1016/S0140-6736(18)30207-1. PMID: 29433850
Vilgrain V, Pereira H, Assenat E, Guiu B, Ilonca AD, Pageaux GP, Sibert A, Bouattour M, Lebtahi R, Allaham W, Barraud H, Laurent V, Mathias E, Bronowicki JP, Tasu JP, Perdrisot R, Silvain C, Gerolami R, Mundler O, Seitz JF, Vidal V, Aubé C, Oberti F, Couturier O, Brenot-Rossi I, Raoul JL, Sarran A, Costentin C, Itti E, Luciani A, Adam R, Lewin M, Samuel D, Ronot M, Dinut A, Castera L, Chatellier G; SARAH Trial Group
Lancet Oncol 2017 Dec;18(12):1624-1636. Epub 2017 Oct 26 doi: 10.1016/S1470-2045(17)30683-6. PMID: 29107679

Clinical prediction guides

Cappuyns S, Corbett V, Yarchoan M, Finn RS, Llovet JM
JAMA Oncol 2024 Mar 1;10(3):395-404. doi: 10.1001/jamaoncol.2023.2677. PMID: 37535375Free PMC Article
Lai Z, He M, Bu X, Xu Y, Huang Y, Wen D, Li Q, Xu L, Zhang Y, Wei W, Chen M, Kan A, Shi M
Eur J Cancer 2022 Oct;174:68-77. Epub 2022 Aug 15 doi: 10.1016/j.ejca.2022.07.005. PMID: 35981413
Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Kong C, Zhao Z, Chen W, Lv X, Shu G, Ye M, Song J, Ying X, Weng Q, Weng W, Fang S, Chen M, Tu J, Ji J
Eur Radiol 2021 Oct;31(10):7500-7511. Epub 2021 Apr 16 doi: 10.1007/s00330-021-07910-0. PMID: 33860832Free PMC Article
El-Khoueiry AB, Sangro B, Yau T, Crocenzi TS, Kudo M, Hsu C, Kim TY, Choo SP, Trojan J, Welling TH Rd, Meyer T, Kang YK, Yeo W, Chopra A, Anderson J, Dela Cruz C, Lang L, Neely J, Tang H, Dastani HB, Melero I
Lancet 2017 Jun 24;389(10088):2492-2502. Epub 2017 Apr 20 doi: 10.1016/S0140-6736(17)31046-2. PMID: 28434648Free PMC Article

Recent systematic reviews

Kudo M, Montal R, Finn RS, Castet F, Ueshima K, Nishida N, Haber PK, Hu Y, Chiba Y, Schwartz M, Meyer T, Lencioni R, Llovet JM
Clin Cancer Res 2022 Aug 15;28(16):3443-3451. doi: 10.1158/1078-0432.CCR-21-3135. PMID: 34907081
Sonbol MB, Riaz IB, Naqvi SAA, Almquist DR, Mina S, Almasri J, Shah S, Almader-Douglas D, Uson Junior PLS, Mahipal A, Ma WW, Jin Z, Mody K, Starr J, Borad MJ, Ahn DH, Murad MH, Bekaii-Saab T
JAMA Oncol 2020 Dec 1;6(12):e204930. Epub 2020 Dec 10 doi: 10.1001/jamaoncol.2020.4930. PMID: 33090186Free PMC Article
Peeraphatdit TB, Wang J, Odenwald MA, Hu S, Hart J, Charlton MR
Hepatology 2020 Jul;72(1):315-329. doi: 10.1002/hep.31227. PMID: 32167613
Rognoni C, Ciani O, Sommariva S, Facciorusso A, Tarricone R, Bhoori S, Mazzaferro V
Oncotarget 2016 Nov 1;7(44):72343-72355. doi: 10.18632/oncotarget.11644. PMID: 27579537Free PMC Article
Ling-lin Z, Li M, Jin-hui T, Ke-hu Y
Zhongguo Yi Xue Ke Xue Yuan Xue Bao 2011 Feb;33(1):51-7. doi: 10.3881/j.issn.1000-503X.2011.01.011. PMID: 21375938

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