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Advanced Pancreatobiliary Carcinoma

MedGen UID:
1720751
•Concept ID:
C5419086
•
Neoplastic Process

Definition

A carcinoma that arises from the pancreas, bile ducts, gallbladder, or ampulla of Vater and has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

REDISCOVER International Guidelines on the Perioperative Care of Surgical Patients With Borderline-resectable and Locally Advanced Pancreatic Cancer.
Boggi U, Kauffmann E, Napoli N, Barreto SG, Besselink MG, Fusai GK, Hackert T, Abu Hilal M, Marchegiani G, Salvia R, Shrikhande SV, Truty M, Werner J, Wolfgang CL, Bannone E, Capretti G, Cattelani A, Coppola A, Cucchetti A, De Sio D, Di Dato A, Di Meo G, Fiorillo C, Gianfaldoni C, Ginesini M, Hidalgo Salinas C, Lai Q, Miccoli M, Montorsi R, Pagnanelli M, Poli A, Ricci C, Sucameli F, Tamburrino D, Viti V, Addeo PF, Alfieri S, Bachellier P, Baiocchi GL, Balzano G, Barbarello L, Brolese A, Busquets J, Butturini G, Caniglia F, Caputo D, Casadei R, Chunhua X, Colangelo E, Coratti A, Costa F, Crafa F, Dalla Valle R, De Carlis L, de Wilde RF, Del Chiaro M, Di Benedetto F, Di Sebastiano P, Dokmak S, Hogg M, Egorov VI, Ercolani G, Ettorre GM, Falconi M, Ferrari G, Ferrero A, Filauro M, Giardino A, Grazi GL, Gruttadauria S, Izbicki JR, Jovine E, Katz M, Keck T, Khatkov I, Kiguchi G, Kooby D, Lang H, Lombardo C, Malleo G, Massani M, Mazzaferro V, Memeo R, Miao Y, Mishima K, Molino C, Nagakawa Y, Nakamura M, Nardo B, Panaro F, Pasquali C, Perrone V, Rangelova E, Liu R, Romagnoli R, Romito R, Rosso E, Schulick R, Siriwardena A, Spampinato MG, Strobel O, Testini M, Troisi RI, Uzunoglo FG, Valente R, Veneroni L, Zerbi A, Vicente E, Vistoli F, Vivarelli M, Wakabayashi G, Zanus G, Zureikat A, Zyromski NJ, Coppola R, D'Andrea V, Davide J, Dervenis C, Frigerio I, Konlon KC, Michelassi F, Montorsi M, Nealon W, Portolani N, Sousa Silva D, Bozzi G, Ferrari V, Trivella MG, Cameron J, Clavien PA, Asbun HJ; REDISCOVER Multidisciplinary Advisory Board
Ann Surg 2024 Jul 1;280(1):56-65. Epub 2024 Feb 26 doi: 10.1097/SLA.0000000000006248. PMID: 38407228Free PMC Article
Expert consensus on the management of adverse events in patients receiving lenvatinib for hepatocellular carcinoma.
Kim BH, Yu SJ, Kang W, Cho SB, Park SY, Kim SU, Kim DY
J Gastroenterol Hepatol 2022 Mar;37(3):428-439. Epub 2021 Nov 17 doi: 10.1111/jgh.15727. PMID: 34725855Free PMC Article
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537

Recent clinical studies

Therapy

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Current evidence and the potential role of proton beam therapy for hepatocellular carcinoma.
Lee SU, Kim TH
Clin Mol Hepatol 2023 Oct;29(4):958-968. Epub 2023 Aug 29 doi: 10.3350/cmh.2023.0274. PMID: 37822213Free PMC Article
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial.
Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Insights and updates on endoscopic papillectomy.
Yamamoto K, Iwasaki E, Itoi T
Expert Rev Gastroenterol Hepatol 2020 Jun;14(6):435-444. Epub 2020 May 22 doi: 10.1080/17474124.2020.1766965. PMID: 32380873

Prognosis

Integrative analysis of spatial and single-cell transcriptome data from human pancreatic cancer reveals an intermediate cancer cell population associated with poor prognosis.
Kim S, Leem G, Choi J, Koh Y, Lee S, Nam SH, Kim JS, Park CH, Hwang HK, Min KI, Jo JH, Lee HS, Chung MJ, Park JY, Park SW, Song SY, Shin EC, Kang CM, Bang S, Park JE
Genome Med 2024 Jan 31;16(1):20. doi: 10.1186/s13073-024-01287-7. PMID: 38297291Free PMC Article
Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Treatment Approach to Adenocarcinoma of the Ampulla of Vater.
Patel M, Uboha NV
Curr Treat Options Oncol 2021 Sep 29;22(11):103. doi: 10.1007/s11864-021-00894-5. PMID: 34586537
Obesity and cholangiocarcinoma.
Parsi MA
World J Gastroenterol 2013 Jan 28;19(4):457-62. doi: 10.3748/wjg.v19.i4.457. PMID: 23382624Free PMC Article

Clinical prediction guides

Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.
Zheng S, Tian Q, Yuan Y, Sun S, Li T, Xia R, He R, Luo Y, Lin Q, Fu Z, Zhou Y, Chen R, Hu C
J Exp Clin Cancer Res 2023 Nov 28;42(1):324. doi: 10.1186/s13046-023-02854-3. PMID: 38012734Free PMC Article
Transarterial radioembolization versus tyrosine kinase inhibitor in hepatocellular carcinoma with portal vein thrombosis.
Hur MH, Cho Y, Kim DY, Lee JS, Kim GM, Kim HC, Sinn DH, Hyun D, Lee HA, Seo YS, Lee IJ, Park JW, Kim YJ
Clin Mol Hepatol 2023 Jul;29(3):763-778. Epub 2023 May 30 doi: 10.3350/cmh.2023.0076. PMID: 37254488Free PMC Article
Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Nivolumab versus sorafenib in advanced hepatocellular carcinoma (CheckMate 459): a randomised, multicentre, open-label, phase 3 trial.
Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Recent Updates in the Management of Advanced Pancreatic Neuroendocrine Tumors.
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555

Recent systematic reviews

Impact of histopathological type on the prognosis of ampullary carcinoma: A systematic review and meta-analysis.
Shin DW, Kim S, Jung K, Jung JH, Kim B, Ahn J, Kim J, Hwang JH, Lee JC
Eur J Surg Oncol 2023 Feb;49(2):306-315. Epub 2022 Oct 9 doi: 10.1016/j.ejso.2022.10.001. PMID: 36272870
Adjuvant therapy for true ampullary cancer: a systematic review.
Bonet M, Rodrigo A, Vázquez S, Carrizo V, Vilardell F, Mira M
Clin Transl Oncol 2020 Aug;22(8):1407-1413. Epub 2020 Jan 11 doi: 10.1007/s12094-019-02278-6. PMID: 31927720

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