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Advanced Gastric Adenocarcinoma

MedGen UID:
1708925
•Concept ID:
C5237824
•
Neoplastic Process

Definition

Gastric adenocarcinoma that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Gastric Adenocarcinoma

Professional guidelines

PubMed

New developments and standard of care in the management of advanced gastric cancer.
Depotte L, Palle J, Rasola C, Broudin C, Afrăsânie VA, Mariani A, Zaanan A
Clin Res Hepatol Gastroenterol 2024 Jan;48(1):102245. Epub 2023 Nov 11 doi: 10.1016/j.clinre.2023.102245. PMID: 37952913
Approach to Resectable Gastric Cancer: Evolving Paradigm of Neoadjuvant and Adjuvant Treatment.
Lumish MA, Ku GY
Curr Treat Options Oncol 2022 Jul;23(7):1044-1058. Epub 2022 May 7 doi: 10.1007/s11864-021-00917-1. PMID: 35524838
Adverse events and management of apatinib in patients with advanced or metastatic cancers: A review.
Shao F, Zhang H, Yang X, Luo X, Liu J
Neoplasma 2020 Jul;67(4):715-723. Epub 2020 Apr 7 doi: 10.4149/neo_2020_190801N701. PMID: 32266817

Recent clinical studies

Therapy

Neoadjuvant docetaxel, oxaliplatin plus capecitabine versus oxaliplatin plus capecitabine for patients with locally advanced gastric adenocarcinoma: long-term results of a phase III randomized controlled trial.
Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Phase 1 multicenter, dose-expansion study of ARX788 as monotherapy in HER2-positive advanced gastric and gastroesophageal junction adenocarcinoma.
Zhang Y, Qiu MZ, Wang JF, Zhang YQ, Shen A, Yuan XL, Zhang T, Wei XL, Zhao HY, Wang DS, Zhao Q, Xiong GZ, Ji YP, Liang XJ, Xia G, Xu RH
Cell Rep Med 2022 Nov 15;3(11):100814. doi: 10.1016/j.xcrm.2022.100814. PMID: 36384091Free PMC Article
Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers.
Scott LJ
Drugs 2018 May;78(7):747-758. doi: 10.1007/s40265-018-0903-9. PMID: 29663291
Advanced gastric adenocarcinoma: optimizing therapy options.
Mizrak Kaya D, Harada K, Shimodaira Y, Amlashi FG, Lin Q, Ajani JA
Expert Rev Clin Pharmacol 2017 Mar;10(3):263-271. Epub 2017 Feb 3 doi: 10.1080/17512433.2017.1279969. PMID: 28094573
Gastroesophageal junction adenocarcinoma.
Swisher SG, Pisters PW, Komaki R, Lahoti S, Ajani JA
Curr Treat Options Oncol 2000 Dec;1(5):387-98. doi: 10.1007/s11864-000-0066-1. PMID: 12057146

Prognosis

Neoadjuvant docetaxel, oxaliplatin plus capecitabine versus oxaliplatin plus capecitabine for patients with locally advanced gastric adenocarcinoma: long-term results of a phase III randomized controlled trial.
Tian Y, Yang P, Guo H, Liu Y, Zhang Z, Ding P, Zheng T, Deng H, Ma W, Li Y, Fan L, Zhang Z, Wang D, Zhao X, Tan B, Liu Y, Zhao Q
Int J Surg 2023 Dec 1;109(12):4000-4008. doi: 10.1097/JS9.0000000000000692. PMID: 37678277Free PMC Article
Neoadjuvant Gastric Score: How Response to Neoadjuvant Chemotherapy Affects Overall Survival and Adjuvant Benefit.
Wehrle CJ, Seavey CN, Chang J, Stackhouse K, Woo K, Augustin T, Joyce D, Simon R, Walsh RM, Naffouje SA
Ann Surg Oncol 2023 Nov;30(12):7240-7250. Epub 2023 Sep 2 doi: 10.1245/s10434-023-14259-9. PMID: 37659978
Patient-Derived Organoids from Locally Advanced Gastric Adenocarcinomas Can Predict Resistance to Neoadjuvant Chemotherapy.
Yoon C, Lu J, Kim BJ, Cho SJ, Kim JH, Moy RH, Ryeom SW, Yoon SS
J Gastrointest Surg 2023 Apr;27(4):666-676. Epub 2023 Jan 10 doi: 10.1007/s11605-022-05568-7. PMID: 36627466
Epithelial SOX9 drives progression and metastases of gastric adenocarcinoma by promoting immunosuppressive tumour microenvironment.
Fan Y, Li Y, Yao X, Jin J, Scott A, Liu B, Wang S, Huo L, Wang Y, Wang R, Pool Pizzi M, Ma L, Shao S, Sewastjanow-Silva M, Waters R, Chatterjee D, Liu B, Shanbhag N, Peng G, Calin GA, Mazur PK, Hanash SM, Ishizawa J, Hirata Y, Nagano O, Wang Z, Wang L, Xian W, McKeon F, Ajani JA, Song S
Gut 2023 Apr;72(4):624-637. Epub 2022 Aug 24 doi: 10.1136/gutjnl-2021-326581. PMID: 36002248
Apatinib: A Review in Advanced Gastric Cancer and Other Advanced Cancers.
Scott LJ
Drugs 2018 May;78(7):747-758. doi: 10.1007/s40265-018-0903-9. PMID: 29663291

Clinical prediction guides

Neoadjuvant Gastric Score: How Response to Neoadjuvant Chemotherapy Affects Overall Survival and Adjuvant Benefit.
Wehrle CJ, Seavey CN, Chang J, Stackhouse K, Woo K, Augustin T, Joyce D, Simon R, Walsh RM, Naffouje SA
Ann Surg Oncol 2023 Nov;30(12):7240-7250. Epub 2023 Sep 2 doi: 10.1245/s10434-023-14259-9. PMID: 37659978
Patient-Derived Organoids from Locally Advanced Gastric Adenocarcinomas Can Predict Resistance to Neoadjuvant Chemotherapy.
Yoon C, Lu J, Kim BJ, Cho SJ, Kim JH, Moy RH, Ryeom SW, Yoon SS
J Gastrointest Surg 2023 Apr;27(4):666-676. Epub 2023 Jan 10 doi: 10.1007/s11605-022-05568-7. PMID: 36627466
The Discordance of Clinical and Pathologic Staging in Locally Advanced Gastric Adenocarcinoma.
Papageorge MV, de Geus SWL, Zheng J, Woods AP, Ng SC, Cassidy MR, McAneny D, Tseng JF, Sachs TE
J Gastrointest Surg 2021 Jun;25(6):1363-1369. Epub 2021 Apr 12 doi: 10.1007/s11605-021-04993-4. PMID: 33846934
Evaluation of PET and laparoscopy in STagIng advanced gastric cancer: a multicenter prospective study (PLASTIC-study).
Brenkman HJF, Gertsen EC, Vegt E, van Hillegersberg R, van Berge Henegouwen MI, Gisbertz SS, Luyer MDP, Nieuwenhuijzen GAP, van Lanschot JJB, Lagarde SM, de Steur WO, Hartgrink HH, Stoot JHMB, Hulsewe KWE, Spillenaar Bilgen EJ, van Det MJ, Kouwenhoven EA, van der Peet DL, Daams F, van Sandick JW, van Grieken NCT, Heisterkamp J, van Etten B, Haveman JW, Pierie JP, Jonker F, Thijssen AY, Belt EJT, van Duijvendijk P, Wassenaar E, van Laarhoven HWM, Wessels FJ, Haj Mohammad N, van Stel HF, Frederix GWJ, Siersema PD, Ruurda JP; PLASTIC Study Group
BMC Cancer 2018 Apr 20;18(1):450. doi: 10.1186/s12885-018-4367-9. PMID: 29678145Free PMC Article
A comprehensive review of S-1 in the treatment of advanced gastric adenocarcinoma.
Blum M, Suzuki A, Ajani JA
Future Oncol 2011 Jun;7(6):715-26. doi: 10.2217/fon.11.50. PMID: 21675835

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