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Advanced Adult Hepatocellular Carcinoma

MedGen UID:
312876
Concept ID:
C1706732
Neoplastic Process
Synonym: Advanced Adult Hepatoma

Definition

A hepatocellular carcinoma that occurs during adulthood and has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Adult Hepatocellular Carcinoma

Professional guidelines

PubMed

European Association for the Study of the Liver (EASL). Electronic address: easloffice@easloffice.eu; European Association for the Study of Diabetes (EASD); European Association for the Study of Obesity (EASO); European Association for the Study of the Liver (EASL)
J Hepatol 2024 Sep;81(3):492-542. Epub 2024 Jun 7 doi: 10.1016/j.jhep.2024.04.031. PMID: 38851997
Reig M, Forner A, Rimola J, Ferrer-Fàbrega J, Burrel M, Garcia-Criado Á, Kelley RK, Galle PR, Mazzaferro V, Salem R, Sangro B, Singal AG, Vogel A, Fuster J, Ayuso C, Bruix J
J Hepatol 2022 Mar;76(3):681-693. Epub 2021 Nov 19 doi: 10.1016/j.jhep.2021.11.018. PMID: 34801630Free PMC Article
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article

Recent clinical studies

Etiology

Lo SH, Sharma R, Costentin CE, Aggio D, Shergill S, Colaone F, Brennan VK, Straccia VA, Agirrezabal I, Lloyd AJ
Future Oncol 2021 Nov;17(32):4275-4287. Epub 2021 Jul 27 doi: 10.2217/fon-2021-0697. PMID: 34313150
Mangia A, Bellini D, Cillo U, Laghi A, Pelle G, Valori VM, Caturelli E
BMC Gastroenterol 2020 Aug 3;20(1):251. doi: 10.1186/s12876-020-01391-z. PMID: 32746786Free PMC Article
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article
Yoon SM, Ryoo BY, Lee SJ, Kim JH, Shin JH, An JH, Lee HC, Lim YS
JAMA Oncol 2018 May 1;4(5):661-669. doi: 10.1001/jamaoncol.2017.5847. PMID: 29543938Free PMC Article
Alves RC, Alves D, Guz B, Matos C, Viana M, Harriz M, Terrabuio D, Kondo M, Gampel O, Polletti P
Ann Hepatol 2011 Jan-Mar;10(1):21-7. PMID: 21301005

Diagnosis

Ding J, Wen Z
BMC Cancer 2021 Oct 29;21(1):1157. doi: 10.1186/s12885-021-08904-3. PMID: 34715816Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Qin S, Ren Z, Meng Z, Chen Z, Chai X, Xiong J, Bai Y, Yang L, Zhu H, Fang W, Lin X, Chen X, Li E, Wang L, Chen C, Zou J
Lancet Oncol 2020 Apr;21(4):571-580. Epub 2020 Feb 26 doi: 10.1016/S1470-2045(20)30011-5. PMID: 32112738
Kulik L, El-Serag HB
Gastroenterology 2019 Jan;156(2):477-491.e1. Epub 2018 Oct 24 doi: 10.1053/j.gastro.2018.08.065. PMID: 30367835Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718

Therapy

Yau T, Park JW, Finn RS, Cheng AL, Mathurin P, Edeline J, Kudo M, Harding JJ, Merle P, Rosmorduc O, Wyrwicz L, Schott E, Choo SP, Kelley RK, Sieghart W, Assenat E, Zaucha R, Furuse J, Abou-Alfa GK, El-Khoueiry AB, Melero I, Begic D, Chen G, Neely J, Wisniewski T, Tschaika M, Sangro B
Lancet Oncol 2022 Jan;23(1):77-90. Epub 2021 Dec 13 doi: 10.1016/S1470-2045(21)00604-5. PMID: 34914889
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Sonbol MB, Riaz IB, Naqvi SAA, Almquist DR, Mina S, Almasri J, Shah S, Almader-Douglas D, Uson Junior PLS, Mahipal A, Ma WW, Jin Z, Mody K, Starr J, Borad MJ, Ahn DH, Murad MH, Bekaii-Saab T
JAMA Oncol 2020 Dec 1;6(12):e204930. Epub 2020 Dec 10 doi: 10.1001/jamaoncol.2020.4930. PMID: 33090186Free PMC Article
Qin S, Ren Z, Meng Z, Chen Z, Chai X, Xiong J, Bai Y, Yang L, Zhu H, Fang W, Lin X, Chen X, Li E, Wang L, Chen C, Zou J
Lancet Oncol 2020 Apr;21(4):571-580. Epub 2020 Feb 26 doi: 10.1016/S1470-2045(20)30011-5. PMID: 32112738
Duffy AG, Ulahannan SV, Makorova-Rusher O, Rahma O, Wedemeyer H, Pratt D, Davis JL, Hughes MS, Heller T, ElGindi M, Uppala A, Korangy F, Kleiner DE, Figg WD, Venzon D, Steinberg SM, Venkatesan AM, Krishnasamy V, Abi-Jaoudeh N, Levy E, Wood BJ, Greten TF
J Hepatol 2017 Mar;66(3):545-551. Epub 2016 Nov 2 doi: 10.1016/j.jhep.2016.10.029. PMID: 27816492Free PMC Article

Prognosis

Mao J, Wang D, Long J, Yang X, Lin J, Song Y, Xie F, Xun Z, Wang Y, Wang Y, Li Y, Sun H, Xue J, Song Y, Zuo B, Zhang J, Bian J, Zhang T, Yang X, Zhang L, Sang X, Zhao H
J Immunother Cancer 2021 Dec;9(12) doi: 10.1136/jitc-2021-003334. PMID: 34873013Free PMC Article
Ding J, Wen Z
BMC Cancer 2021 Oct 29;21(1):1157. doi: 10.1186/s12885-021-08904-3. PMID: 34715816Free PMC Article
Qin S, Li Q, Gu S, Chen X, Lin L, Wang Z, Xu A, Chen X, Zhou C, Ren Z, Yang L, Xu L, Bai Y, Chen L, Li J, Pan H, Cao B, Fang W, Wu W, Wang G, Cheng Y, Yu Z, Zhu X, Jiang D, Lu Y, Wang H, Xu J, Bai L, Liu Y, Lin H, Wu C, Zhang Y, Yan P, Jin C, Zou J
Lancet Gastroenterol Hepatol 2021 Jul;6(7):559-568. Epub 2021 May 8 doi: 10.1016/S2468-1253(21)00109-6. PMID: 33971141
Vibert E, Schwartz M, Olthoff KM
J Hepatol 2020 Feb;72(2):262-276. doi: 10.1016/j.jhep.2019.11.017. PMID: 31954491
Deeks ED
Target Oncol 2019 Feb;14(1):107-113. doi: 10.1007/s11523-019-00622-y. PMID: 30767164

Clinical prediction guides

Nault JC, Martin Y, Caruso S, Hirsch TZ, Bayard Q, Calderaro J, Charpy C, Copie-Bergman C, Ziol M, Bioulac-Sage P, Couchy G, Blanc JF, Nahon P, Amaddeo G, Ganne-Carrie N, Morcrette G, Chiche L, Duvoux C, Faivre S, Laurent A, Imbeaud S, Rebouissou S, Llovet JM, Seror O, Letouzé E, Zucman-Rossi J
Hepatology 2020 Jan;71(1):164-182. Epub 2019 Aug 12 doi: 10.1002/hep.30811. PMID: 31206197
Li B, Cao Y, Meng G, Qian L, Xu T, Yan C, Luo O, Wang S, Wei J, Ding Y, Yu D
EBioMedicine 2019 Jan;39:239-254. Epub 2018 Dec 13 doi: 10.1016/j.ebiom.2018.11.063. PMID: 30555042Free PMC Article
Pinyol R, Montal R, Bassaganyas L, Sia D, Takayama T, Chau GY, Mazzaferro V, Roayaie S, Lee HC, Kokudo N, Zhang Z, Torrecilla S, Moeini A, Rodriguez-Carunchio L, Gane E, Verslype C, Croitoru AE, Cillo U, de la Mata M, Lupo L, Strasser S, Park JW, Camps J, Solé M, Thung SN, Villanueva A, Pena C, Meinhardt G, Bruix J, Llovet JM
Gut 2019 Jun;68(6):1065-1075. Epub 2018 Aug 14 doi: 10.1136/gutjnl-2018-316408. PMID: 30108162Free PMC Article
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718
Yoon SM, Ryoo BY, Lee SJ, Kim JH, Shin JH, An JH, Lee HC, Lim YS
JAMA Oncol 2018 May 1;4(5):661-669. doi: 10.1001/jamaoncol.2017.5847. PMID: 29543938Free PMC Article

Recent systematic reviews

Thomas JA, Kendall BJ, Dalais C, Macdonald GA, Thrift AP
Eur J Cancer 2022 Sep;173:250-262. Epub 2022 Aug 6 doi: 10.1016/j.ejca.2022.06.051. PMID: 35944373
Sonbol MB, Riaz IB, Naqvi SAA, Almquist DR, Mina S, Almasri J, Shah S, Almader-Douglas D, Uson Junior PLS, Mahipal A, Ma WW, Jin Z, Mody K, Starr J, Borad MJ, Ahn DH, Murad MH, Bekaii-Saab T
JAMA Oncol 2020 Dec 1;6(12):e204930. Epub 2020 Dec 10 doi: 10.1001/jamaoncol.2020.4930. PMID: 33090186Free PMC Article
Jarvis H, Craig D, Barker R, Spiers G, Stow D, Anstee QM, Hanratty B
PLoS Med 2020 Apr;17(4):e1003100. Epub 2020 Apr 30 doi: 10.1371/journal.pmed.1003100. PMID: 32353039Free PMC Article
Peng JK, Hepgul N, Higginson IJ, Gao W
Palliat Med 2019 Jan;33(1):24-36. Epub 2018 Oct 22 doi: 10.1177/0269216318807051. PMID: 30345878Free PMC Article
Vernon G, Baranova A, Younossi ZM
Aliment Pharmacol Ther 2011 Aug;34(3):274-85. Epub 2011 May 30 doi: 10.1111/j.1365-2036.2011.04724.x. PMID: 21623852

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      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

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