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Bile duct neoplasm

MedGen UID:
14114
•Concept ID:
C0005396
•
Neoplastic Process
Synonyms: Bile Duct Neoplasm; Bile Duct Neoplasms; Neoplasm, Bile Duct; Neoplasms, Bile Duct
 
Monarch Initiative: MONDO:0021662

Definition

A benign or malignant neoplasm that affects the intrahepatic or extrahepatic bile ducts. Representative examples of benign neoplasms include bile duct adenoma and extrahepatic bile duct lipoma. Representative examples of malignant neoplasms include intrahepatic and extrahepatic cholangiocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBile duct neoplasm

Professional guidelines

PubMed

EASL-ILCA Clinical Practice Guidelines on the management of intrahepatic cholangiocarcinoma.
European Association for the Study of the Liver. Electronic address: easloffice@easloffice.eu; European Association for the Study of the Liver
J Hepatol 2023 Jul;79(1):181-208. Epub 2023 Apr 20 doi: 10.1016/j.jhep.2023.03.010. PMID: 37084797
Cholangiocarcinoma 2020: the next horizon in mechanisms and management.
Banales JM, Marin JJG, Lamarca A, Rodrigues PM, Khan SA, Roberts LR, Cardinale V, Carpino G, Andersen JB, Braconi C, Calvisi DF, Perugorria MJ, Fabris L, Boulter L, Macias RIR, Gaudio E, Alvaro D, Gradilone SA, Strazzabosco M, Marzioni M, Coulouarn C, Fouassier L, Raggi C, Invernizzi P, Mertens JC, Moncsek A, Ilyas SI, Heimbach J, Koerkamp BG, Bruix J, Forner A, Bridgewater J, Valle JW, Gores GJ
Nat Rev Gastroenterol Hepatol 2020 Sep;17(9):557-588. Epub 2020 Jun 30 doi: 10.1038/s41575-020-0310-z. PMID: 32606456Free PMC Article
Pathogenesis, diagnosis, and management of cholangiocarcinoma.
Ilyas SI, Gores GJ
Gastroenterology 2013 Dec;145(6):1215-29. Epub 2013 Oct 15 doi: 10.1053/j.gastro.2013.10.013. PMID: 24140396Free PMC Article

Recent clinical studies

Etiology

Vascular resection for distal cholangiocarcinoma.
Yamamoto R, Sugiura T, Ashida R, Ohgi K, Yamada M, Otsuka S, Aramaki T, Asakura K, Uesaka K
Surg Today 2023 Aug;53(8):899-906. Epub 2022 Dec 23 doi: 10.1007/s00595-022-02634-0. PMID: 36550287
Intravenous combined with intrabiliary contrast-enhanced ultrasound in the evaluation of resectability of hilar cholangiocarcinomas.
Jianxiong W, Yu W, Juyi W, Guangxia W
J Clin Ultrasound 2022 Sep;50(7):931-939. Epub 2022 Jul 8 doi: 10.1002/jcu.23268. PMID: 35808898
Impact of surgery on survival outcomes for Bismuth type IV Klatskin tumors.
Choi YJ, Lee JM, Kang JS, Sohn HJ, Byun Y, Han Y, Kim H, Kwon W, Jang JY
J Gastrointest Surg 2022 Sep;26(9):1890-1898. Epub 2022 Jun 9 doi: 10.1007/s11605-022-05293-1. PMID: 35680776
Survival outcomes of hepatic resections in Bismuth-Corlette type IV cholangiocarcinoma.
Ku D, Tang R, Pang T, Pleass H, Richardson A, Yuen L, Lam V
ANZ J Surg 2020 Sep;90(9):1604-1614. Epub 2019 Dec 15 doi: 10.1111/ans.15531. PMID: 31840387
Anterior approach for perihilar cholangiocarcinoma (with video).
Higuchi R, Yazawa T, Uemura S, Yamamoto M
J Surg Res 2016 May 1;202(1):71-6. Epub 2015 Dec 17 doi: 10.1016/j.jss.2015.12.009. PMID: 27083950

Diagnosis

Current Perspectives in Liver Transplantation for Perihilar Cholangiocarcinoma.
Giovinazzo F, Pascale MM, Cardella F, Picarelli M, Molica S, Zotta F, Martullo A, Clarke G, Frongillo F, Grieco A, Agnes S
Curr Oncol 2023 Mar 1;30(3):2942-2953. doi: 10.3390/curroncol30030225. PMID: 36975438Free PMC Article
Intravenous combined with intrabiliary contrast-enhanced ultrasound in the evaluation of resectability of hilar cholangiocarcinomas.
Jianxiong W, Yu W, Juyi W, Guangxia W
J Clin Ultrasound 2022 Sep;50(7):931-939. Epub 2022 Jul 8 doi: 10.1002/jcu.23268. PMID: 35808898
Impact of surgery on survival outcomes for Bismuth type IV Klatskin tumors.
Choi YJ, Lee JM, Kang JS, Sohn HJ, Byun Y, Han Y, Kim H, Kwon W, Jang JY
J Gastrointest Surg 2022 Sep;26(9):1890-1898. Epub 2022 Jun 9 doi: 10.1007/s11605-022-05293-1. PMID: 35680776
Distal bile duct carcinomas and pancreatic ductal adenocarcinomas: postulating a common tumor entity.
Schmuck RB, de Carvalho-Fischer CV, Neumann C, Pratschke J, Bahra M
Cancer Med 2016 Jan;5(1):88-99. Epub 2015 Dec 9 doi: 10.1002/cam4.566. PMID: 26645826Free PMC Article
Intraductal papillary neoplasm of the bile ducts: A case report and literature review.
Tan Y, Milikowski C, Toribio Y, Singer A, Rojas CP, Garcia-Buitrago MT
World J Gastroenterol 2015 Nov 21;21(43):12498-504. doi: 10.3748/wjg.v21.i43.12498. PMID: 26604656Free PMC Article

Therapy

Survival outcomes of hepatic resections in Bismuth-Corlette type IV cholangiocarcinoma.
Ku D, Tang R, Pang T, Pleass H, Richardson A, Yuen L, Lam V
ANZ J Surg 2020 Sep;90(9):1604-1614. Epub 2019 Dec 15 doi: 10.1111/ans.15531. PMID: 31840387
Diagnostic approach using ERCP-guided transpapillary forceps biopsy or EUS-guided fine-needle aspiration biopsy according to the nature of stricture segment for patients with suspected malignant biliary stricture.
Lee YN, Moon JH, Choi HJ, Kim HK, Choi SY, Choi MH, Lee TH, Lee TH, Cha SW, Park SH
Cancer Med 2017 Mar;6(3):582-590. Epub 2017 Feb 21 doi: 10.1002/cam4.1034. PMID: 28220692Free PMC Article
Photodynamic therapy for high-grade dysplasia of bile duct via a choledochoscope.
Zhou JJ, Xiong L, Li QL, Gu Y, Wen Y, Deng XF, Miao XY
World J Gastroenterol 2013 Sep 7;19(33):5590-2. doi: 10.3748/wjg.v19.i33.5590. PMID: 24023506Free PMC Article

Prognosis

Vascular resection for distal cholangiocarcinoma.
Yamamoto R, Sugiura T, Ashida R, Ohgi K, Yamada M, Otsuka S, Aramaki T, Asakura K, Uesaka K
Surg Today 2023 Aug;53(8):899-906. Epub 2022 Dec 23 doi: 10.1007/s00595-022-02634-0. PMID: 36550287
Survival outcomes of hepatic resections in Bismuth-Corlette type IV cholangiocarcinoma.
Ku D, Tang R, Pang T, Pleass H, Richardson A, Yuen L, Lam V
ANZ J Surg 2020 Sep;90(9):1604-1614. Epub 2019 Dec 15 doi: 10.1111/ans.15531. PMID: 31840387
Preoperative Platelet to Albumin Ratio Predicts Outcome of Patients with Cholangiocarcinoma.
Saito N, Shirai Y, Horiuchi T, Sugano H, Shiba H, Sakamoto T, Uwagawa T, Yanaga K
Anticancer Res 2018 Feb;38(2):987-992. doi: 10.21873/anticanres.12313. PMID: 29374731
Epidemiological survey of biomarkers of hepatitis virus in patients with extrahepatic cholangiocarcinomas.
Qu Z, Cui N, Qin M, Wu X
Asia Pac J Clin Oncol 2012 Mar;8(1):83-7. Epub 2012 Jan 12 doi: 10.1111/j.1743-7563.2011.01466.x. PMID: 22369448
Biliary granular cell tumor: a little-known curable bile duct neoplasm of young people.
Butterly LF, Schapiro RH, LaMuraglia GM, Warshaw AL
Surgery 1988 Mar;103(3):328-34. PMID: 2830680

Clinical prediction guides

Prognostic significance of stem cell/ epithelial-mesenchymal transition markers in periampullary/pancreatic cancers: FGFR1 is a promising prognostic marker.
Chong Y, Thakur N, Paik KY, Lee EJ, Kang CS
BMC Cancer 2020 Mar 14;20(1):216. doi: 10.1186/s12885-020-6673-2. PMID: 32171280Free PMC Article
Survival outcomes of hepatic resections in Bismuth-Corlette type IV cholangiocarcinoma.
Ku D, Tang R, Pang T, Pleass H, Richardson A, Yuen L, Lam V
ANZ J Surg 2020 Sep;90(9):1604-1614. Epub 2019 Dec 15 doi: 10.1111/ans.15531. PMID: 31840387
Preoperative Platelet to Albumin Ratio Predicts Outcome of Patients with Cholangiocarcinoma.
Saito N, Shirai Y, Horiuchi T, Sugano H, Shiba H, Sakamoto T, Uwagawa T, Yanaga K
Anticancer Res 2018 Feb;38(2):987-992. doi: 10.21873/anticanres.12313. PMID: 29374731
Added value of ancillary imaging features for differentiating scirrhous hepatocellular carcinoma from intrahepatic cholangiocarcinoma on gadoxetic acid-enhanced MR imaging.
Choi SY, Kim YK, Min JH, Kang TW, Jeong WK, Ahn S, Won H
Eur Radiol 2018 Jun;28(6):2549-2560. Epub 2018 Jan 15 doi: 10.1007/s00330-017-5196-y. PMID: 29335868
Differential expression of cyclooxygenase-2 (COX-2) in human bile duct epithelial cells and bile duct neoplasm.
Hayashi N, Yamamoto H, Hiraoka N, Dono K, Ito Y, Okami J, Kondo M, Nagano H, Umeshita K, Sakon M, Matsuura N, Nakamori S, Monden M
Hepatology 2001 Oct;34(4 Pt 1):638-50. doi: 10.1053/jhep.2001.28198. PMID: 11584358

Recent systematic reviews

Survival outcomes of hepatic resections in Bismuth-Corlette type IV cholangiocarcinoma.
Ku D, Tang R, Pang T, Pleass H, Richardson A, Yuen L, Lam V
ANZ J Surg 2020 Sep;90(9):1604-1614. Epub 2019 Dec 15 doi: 10.1111/ans.15531. PMID: 31840387
Comparison between liver transplantation and resection for hilar cholangiocarcinoma: A systematic review and meta-analysis.
Moris D, Kostakis ID, Machairas N, Prodromidou A, Tsilimigras DI, Ravindra KV, Sudan DL, Knechtle SJ, Barbas AS
PLoS One 2019;14(7):e0220527. Epub 2019 Jul 31 doi: 10.1371/journal.pone.0220527. PMID: 31365594Free PMC Article

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