U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Intrahepatic Bile Duct Biliary Intraepithelial Neoplasia

MedGen UID:
474764
•Concept ID:
C3273131
•
Neoplastic Process
Synonyms: Intrahepatic Bile Duct BilIN; Intrahepatic Bile Duct Dysplasia

Definition

A neoplastic, non-invasive lesion that affects the intrahepatic bile duct epithelium. It is characterized by the presence of atypical epithelial cells with an increased nuclear/cytoplasmic ratio, nuclear hyperchromasia, and loss of nuclear polarity. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIntrahepatic Bile Duct Biliary Intraepithelial Neoplasia

Professional guidelines

PubMed

Hepatic Cysts: Reappraisal of the Classification, Terminology, Differential Diagnosis, and Clinicopathologic Characteristics in 258 Cases.
Armutlu A, Quigley B, Choi H, Basturk O, Akkas G, Pehlivanoglu B, Memis B, Jang KT, Erkan M, Erkan B, Balci S, Saka B, Bagci P, Farris AB, Kooby DA, Martin D, Kalb B, Maithel SK, Sarmiento J, Reid MD, Adsay NV
Am J Surg Pathol 2022 Sep 1;46(9):1219-1233. Epub 2022 Jul 4 doi: 10.1097/PAS.0000000000001930. PMID: 35778790
A statement by the Japan-Korea expert pathologists for future clinicopathological and molecular analyses toward consensus building of intraductal papillary neoplasm of the bile duct through several opinions at the present stage.
Nakanuma Y, Jang KT, Fukushima N, Furukawa T, Hong SM, Kim H, Lee KB, Zen Y, Jang JY, Kubota K
J Hepatobiliary Pancreat Sci 2018 Mar;25(3):181-187. Epub 2018 Feb 12 doi: 10.1002/jhbp.532. PMID: 29272078
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article

Recent clinical studies

Etiology

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma.
Calderaro J, Ghaffari Laleh N, Zeng Q, Maille P, Favre L, Pujals A, Klein C, Bazille C, Heij LR, Uguen A, Luedde T, Di Tommaso L, Beaufrère A, Chatain A, Gastineau D, Nguyen CT, Nguyen-Canh H, Thi KN, Gnemmi V, Graham RP, Charlotte F, Wendum D, Vij M, Allende DS, Aucejo F, Diaz A, Rivière B, Herrero A, Evert K, Calvisi DF, Augustin J, Leow WQ, Leung HHW, Boleslawski E, Rela M, François A, Cha AW, Forner A, Reig M, Allaire M, Scatton O, Chatelain D, Boulagnon-Rombi C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Gopal P, Brustia R, Vibert E, Schulze K, Rüther DF, Weidemann SA, Rhaiem R, Pawlotsky JM, Zhang X, Luciani A, Mulé S, Laurent A, Amaddeo G, Regnault H, De Martin E, Sempoux C, Navale P, Westerhoff M, Lo RC, Bednarsch J, Gouw A, Guettier C, Lequoy M, Harada K, Sripongpun P, Wetwittayaklang P, Loménie N, Tantipisit J, Kaewdech A, Shen J, Paradis V, Caruso S, Kather JN
Nat Commun 2023 Dec 14;14(1):8290. doi: 10.1038/s41467-023-43749-3. PMID: 38092727Free PMC Article
Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.
Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996
Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma.
Kim HJ, Kim JS, Kim BH, Bak YT
Dig Surg 2018;35(2):116-120. Epub 2017 May 11 doi: 10.1159/000475848. PMID: 28490009
Adult bile duct strictures: differentiating benign biliary stenosis from cholangiocarcinoma.
Nguyen Canh H, Harada K
Med Mol Morphol 2016 Dec;49(4):189-202. Epub 2016 Jun 27 doi: 10.1007/s00795-016-0143-6. PMID: 27350291

Diagnosis

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma.
Calderaro J, Ghaffari Laleh N, Zeng Q, Maille P, Favre L, Pujals A, Klein C, Bazille C, Heij LR, Uguen A, Luedde T, Di Tommaso L, Beaufrère A, Chatain A, Gastineau D, Nguyen CT, Nguyen-Canh H, Thi KN, Gnemmi V, Graham RP, Charlotte F, Wendum D, Vij M, Allende DS, Aucejo F, Diaz A, Rivière B, Herrero A, Evert K, Calvisi DF, Augustin J, Leow WQ, Leung HHW, Boleslawski E, Rela M, François A, Cha AW, Forner A, Reig M, Allaire M, Scatton O, Chatelain D, Boulagnon-Rombi C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Gopal P, Brustia R, Vibert E, Schulze K, Rüther DF, Weidemann SA, Rhaiem R, Pawlotsky JM, Zhang X, Luciani A, Mulé S, Laurent A, Amaddeo G, Regnault H, De Martin E, Sempoux C, Navale P, Westerhoff M, Lo RC, Bednarsch J, Gouw A, Guettier C, Lequoy M, Harada K, Sripongpun P, Wetwittayaklang P, Loménie N, Tantipisit J, Kaewdech A, Shen J, Paradis V, Caruso S, Kather JN
Nat Commun 2023 Dec 14;14(1):8290. doi: 10.1038/s41467-023-43749-3. PMID: 38092727Free PMC Article
Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
INTRAHEPATIC BILIARY PROLIFERATIONS: HISTOPATHOLOGY AND POTENTIAL IMMUNOHISTOCHEMICAL MARKERS.
Hirayama AB, Mello ES, Alves VAF
Arq Gastroenterol 2023 Jul-Sep;60(3):393-403. doi: 10.1590/S0004-2803.23032023-107. PMID: 37792770
Bile duct dysplasia and associated invasive carcinoma: clinicopathological features, diagnosis, and practical challenges.
Liu Y, Yeh MM
Hum Pathol 2023 Feb;132:158-168. Epub 2022 Jun 14 doi: 10.1016/j.humpath.2022.06.012. PMID: 35714833
Anatomical, histomorphological and molecular classification of cholangiocarcinoma.
Kendall T, Verheij J, Gaudio E, Evert M, Guido M, Goeppert B, Carpino G
Liver Int 2019 May;39 Suppl 1:7-18. doi: 10.1111/liv.14093. PMID: 30882996

Therapy

The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma.
Sato Y, Kinoshita M, Takemura S, Tanaka S, Hamano G, Nakamori S, Fujikawa M, Sugawara Y, Yamamoto T, Arimoto A, Yamamura M, Sasaki M, Harada K, Nakanuma Y, Kubo S
Pathol Int 2017 Mar;67(3):163-170. Epub 2017 Jan 31 doi: 10.1111/pin.12511. PMID: 28139862
Comparison of clinicopathological characteristics between patients with occupational and non-occupational intrahepatic cholangiocarcinoma.
Hamano G, Kubo S, Takemura S, Tanaka S, Shinkawa H, Kinoshita M, Ito T, Yamamoto T, Wakasa K, Shibata T
J Hepatobiliary Pancreat Sci 2016 Jul;23(7):389-96. Epub 2016 May 3 doi: 10.1002/jhbp.353. PMID: 27062258
Characteristics of printing company workers newly diagnosed with occupational cholangiocarcinoma.
Kubo S, Kinoshita M, Takemura S, Tanaka S, Shinkawa H, Nishioka T, Hamano G, Ito T, Abue M, Aoki M, Nakagawa K, Unno M, Hijioka S, Fujiyoshi T, Shimizu Y, Mizuguchi T, Shirabe K, Nishie A, Oda Y, Takenaka K, Kobarai T, Hisano T, Saiura A, Numao H, Toda M, Kuwae Y, Nakanuma Y, Endo G
J Hepatobiliary Pancreat Sci 2014 Nov;21(11):809-17. Epub 2014 Aug 3 doi: 10.1002/jhbp.137. PMID: 25088751
Pathogenesis of primary sclerosing cholangitis and advances in diagnosis and management.
Eaton JE, Talwalkar JA, Lazaridis KN, Gores GJ, Lindor KD
Gastroenterology 2013 Sep;145(3):521-36. Epub 2013 Jul 1 doi: 10.1053/j.gastro.2013.06.052. PMID: 23827861Free PMC Article
Precancerous bile duct pathology in end-stage primary sclerosing cholangitis, with and without cholangiocarcinoma.
Lewis JT, Talwalkar JA, Rosen CB, Smyrk TC, Abraham SC
Am J Surg Pathol 2010 Jan;34(1):27-34. doi: 10.1097/PAS.0b013e3181bc96f9. PMID: 19898228

Prognosis

Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma.
Calderaro J, Ghaffari Laleh N, Zeng Q, Maille P, Favre L, Pujals A, Klein C, Bazille C, Heij LR, Uguen A, Luedde T, Di Tommaso L, Beaufrère A, Chatain A, Gastineau D, Nguyen CT, Nguyen-Canh H, Thi KN, Gnemmi V, Graham RP, Charlotte F, Wendum D, Vij M, Allende DS, Aucejo F, Diaz A, Rivière B, Herrero A, Evert K, Calvisi DF, Augustin J, Leow WQ, Leung HHW, Boleslawski E, Rela M, François A, Cha AW, Forner A, Reig M, Allaire M, Scatton O, Chatelain D, Boulagnon-Rombi C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Gopal P, Brustia R, Vibert E, Schulze K, Rüther DF, Weidemann SA, Rhaiem R, Pawlotsky JM, Zhang X, Luciani A, Mulé S, Laurent A, Amaddeo G, Regnault H, De Martin E, Sempoux C, Navale P, Westerhoff M, Lo RC, Bednarsch J, Gouw A, Guettier C, Lequoy M, Harada K, Sripongpun P, Wetwittayaklang P, Loménie N, Tantipisit J, Kaewdech A, Shen J, Paradis V, Caruso S, Kather JN
Nat Commun 2023 Dec 14;14(1):8290. doi: 10.1038/s41467-023-43749-3. PMID: 38092727Free PMC Article
Intraductal papillary neoplasm of the bile duct: The new frontier of biliary pathology.
Mocchegiani F, Vincenzi P, Conte G, Nicolini D, Rossi R, Cacciaguerra AB, Vivarelli M
World J Gastroenterol 2023 Oct 14;29(38):5361-5373. doi: 10.3748/wjg.v29.i38.5361. PMID: 37900587Free PMC Article
Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973
Clinicopathologic Study of Biliary Intraepithelial Neoplasia in Cholangiocarcinoma.
Kim HJ, Kim JS, Kim BH, Bak YT
Dig Surg 2018;35(2):116-120. Epub 2017 May 11 doi: 10.1159/000475848. PMID: 28490009
Imaging bile duct tumors: pathologic concepts, classification, and early tumor detection.
Joo I, Lee JM
Abdom Imaging 2013 Dec;38(6):1334-50. doi: 10.1007/s00261-013-0027-3. PMID: 23925840

Clinical prediction guides

Clinical implications of pediatric biliary intraepithelial neoplasia diagnosed from a choledochal cyst specimen.
Gang S, Kwon H, Song IH, Namgoong JM
World J Surg Oncol 2024 Apr 20;22(1):105. doi: 10.1186/s12957-024-03384-8. PMID: 38643155Free PMC Article
Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma.
Calderaro J, Ghaffari Laleh N, Zeng Q, Maille P, Favre L, Pujals A, Klein C, Bazille C, Heij LR, Uguen A, Luedde T, Di Tommaso L, Beaufrère A, Chatain A, Gastineau D, Nguyen CT, Nguyen-Canh H, Thi KN, Gnemmi V, Graham RP, Charlotte F, Wendum D, Vij M, Allende DS, Aucejo F, Diaz A, Rivière B, Herrero A, Evert K, Calvisi DF, Augustin J, Leow WQ, Leung HHW, Boleslawski E, Rela M, François A, Cha AW, Forner A, Reig M, Allaire M, Scatton O, Chatelain D, Boulagnon-Rombi C, Sturm N, Menahem B, Frouin E, Tougeron D, Tournigand C, Kempf E, Kim H, Ningarhari M, Michalak-Provost S, Gopal P, Brustia R, Vibert E, Schulze K, Rüther DF, Weidemann SA, Rhaiem R, Pawlotsky JM, Zhang X, Luciani A, Mulé S, Laurent A, Amaddeo G, Regnault H, De Martin E, Sempoux C, Navale P, Westerhoff M, Lo RC, Bednarsch J, Gouw A, Guettier C, Lequoy M, Harada K, Sripongpun P, Wetwittayaklang P, Loménie N, Tantipisit J, Kaewdech A, Shen J, Paradis V, Caruso S, Kather JN
Nat Commun 2023 Dec 14;14(1):8290. doi: 10.1038/s41467-023-43749-3. PMID: 38092727Free PMC Article
Imaging bile duct tumors: pathologic concepts, classification, and early tumor detection.
Joo I, Lee JM
Abdom Imaging 2013 Dec;38(6):1334-50. doi: 10.1007/s00261-013-0027-3. PMID: 23925840
Intraductal neoplasm of the intrahepatic bile duct: clinicopathological study of 24 cases.
Naito Y, Kusano H, Nakashima O, Sadashima E, Hattori S, Taira T, Kawahara A, Okabe Y, Shimamatsu K, Taguchi J, Momosaki S, Irie K, Yamaguchi R, Yokomizo H, Nagamine M, Fukuda S, Sugiyama S, Nishida N, Higaki K, Yoshitomi M, Yasunaga M, Okuda K, Kinoshita H, Nakayama M, Yasumoto M, Akiba J, Kage M, Yano H
World J Gastroenterol 2012 Jul 28;18(28):3673-80. doi: 10.3748/wjg.v18.i28.3673. PMID: 22851859Free PMC Article
Significance of mucin expression in pancreatobiliary neoplasms.
Yonezawa S, Higashi M, Yamada N, Yokoyama S, Goto M
J Hepatobiliary Pancreat Sci 2010 Mar;17(2):108-24. Epub 2009 Sep 29 doi: 10.1007/s00534-009-0174-7. PMID: 19787286

Recent systematic reviews

Pathological aspects of mucinous cholangiocarcinoma: A single-center experience and systematic review.
Laohawetwanit T, Klaikaew N
Pathol Int 2020 Sep;70(9):661-670. Epub 2020 Jul 7 doi: 10.1111/pin.12983. PMID: 32638458

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...