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Bile duct adenoma

MedGen UID:
918
•Concept ID:
C0008309
•
Neoplastic Process
Synonyms: Adenoma, Bile Duct; Adenomas, Bile Duct; Bile Duct Adenoma; Bile Duct Adenomas; Cholangioma; Cholangiomas
SNOMED CT: Cholangioadenoma (424091006); Bile duct adenoma (39471001); Cholangioma (39471001)
 
Monarch Initiative: MONDO:0006108

Definition

A benign, well-demarcated polypoid neoplasm arising from the bile duct epithelium. According to the growth pattern, it is classified as tubular, papillary, or tubulopapillary. Adenomas arising from the extrahepatic bile ducts usually produce symptoms related to biliary obstruction. [from NCI]

Professional guidelines

PubMed

Cholangiocarcinoma: A position paper by the Italian Society of Gastroenterology (SIGE), the Italian Association of Hospital Gastroenterology (AIGO), the Italian Association of Medical Oncology (AIOM) and the Italian Association of Oncological Radiotherapy (AIRO).
Alvaro D, Cannizzaro R, Labianca R, Valvo F, Farinati F; Italian Society of Gastroenterology (SIGE); Italian Association of Hospital Gastroenterology (AIGO); Italian Association of Medical Oncology (AIOM); Italian Association of Oncological Radiotherapy (AIRO)
Dig Liver Dis 2010 Dec;42(12):831-8. Epub 2010 Aug 11 doi: 10.1016/j.dld.2010.06.005. PMID: 20702152

Recent clinical studies

Etiology

Bile duct adenoma: imaging features and radiologic-pathologic correlation.
Tatsumi R, Ichihara S, Suii H, Yamaguchi M, Arakawa T, Nakajima T, Kuwata Y, Ozeki I, Hige S, Toyota J, Karino Y
Jpn J Radiol 2020 Jun;38(6):561-571. Epub 2020 Mar 3 doi: 10.1007/s11604-020-00938-0. PMID: 32128668
Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973
Imaging features of bile duct adenoma: case series and review of literature.
Chuy JA, Garg I, Graham RP, VanBuren WM, Venkatesh SK
Diagn Interv Radiol 2018 Sep;24(5):249-254. doi: 10.5152/dir.2018.18036. PMID: 30211677Free PMC Article
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132
Cholangiocarcinoma complicating primary sclerosing cholangitis.
Rosen CB, Nagorney DM
Semin Liver Dis 1991 Feb;11(1):26-30. doi: 10.1055/s-2008-1040419. PMID: 1646485

Diagnosis

INTRAHEPATIC BILIARY PROLIFERATIONS: HISTOPATHOLOGY AND POTENTIAL IMMUNOHISTOCHEMICAL MARKERS.
Hirayama AB, Mello ES, Alves VAF
Arq Gastroenterol 2023 Jul-Sep;60(3):393-403. doi: 10.1590/S0004-2803.23032023-107. PMID: 37792770
Bile duct adenoma may be a precursor lesion of small duct type intrahepatic cholangiocarcinoma.
Sasaki M, Sato Y, Nakanuma Y
Histopathology 2021 Jan;78(2):310-320. Epub 2020 Sep 15 doi: 10.1111/his.14222. PMID: 33405289
Bile duct adenoma: imaging features and radiologic-pathologic correlation.
Tatsumi R, Ichihara S, Suii H, Yamaguchi M, Arakawa T, Nakajima T, Kuwata Y, Ozeki I, Hige S, Toyota J, Karino Y
Jpn J Radiol 2020 Jun;38(6):561-571. Epub 2020 Mar 3 doi: 10.1007/s11604-020-00938-0. PMID: 32128668
Benign hepatic tumours.
Biecker E, Fischer HP, Strunk H, Sauerbruch T
Z Gastroenterol 2003 Feb;41(2):191-200. doi: 10.1055/s-2003-37316. PMID: 12650132
Cholangiocarcinoma.
Kaude J, Rian R
Radiology 1971 Sep;100(3):573-80. doi: 10.1148/100.3.573. PMID: 4327847

Therapy

Cholangiocarcinoma.
Yeo CJ, Pitt HA, Cameron JL
Surg Clin North Am 1990 Dec;70(6):1429-47. doi: 10.1016/s0039-6109(16)45293-x. PMID: 2174191
Obstructive jaundice. Causes and surgical interventions.
Fry DE
Postgrad Med 1988 Oct;84(5):217-22, 227, 230. doi: 10.1080/00325481.1988.11700446. PMID: 2845377
Pathomorphologic characteristics of 102 cases of thorotrast-related hepatocellular carcinoma, cholangiocarcinoma, and hepatic angiosarcoma.
Ito Y, Kojiro M, Nakashima T, Mori T
Cancer 1988 Sep 15;62(6):1153-62. doi: 10.1002/1097-0142(19880915)62:6<1153::aid-cncr2820620619>3.0.co;2-i. PMID: 2457426
Chemotherapy and radiotherapy of malignant hepatic tumours.
Forbes A, Williams R
Baillieres Clin Gastroenterol 1987 Jan;1(1):151-69. doi: 10.1016/0950-3528(87)90038-8. PMID: 3034357
Clinical liver transplantation.
Starzi TE, Brettschneider L, Penn I, Giles G, Picache R, Putnam CW
Transplant Rev 1969;2:3-68. doi: 10.1111/j.1600-065x.1969.tb00206.x. PMID: 4333563

Prognosis

Cholangiocarcinoma: Classification, Histopathology and Molecular Carcinogenesis.
Lendvai G, Szekerczés T, Illyés I, Dóra R, Kontsek E, Gógl A, Kiss A, Werling K, Kovalszky I, Schaff Z, Borka K
Pathol Oncol Res 2020 Jan;26(1):3-15. Epub 2018 Nov 17 doi: 10.1007/s12253-018-0491-8. PMID: 30448973
Proliferative index facilitates distinction between benign biliary lesions and intrahepatic cholangiocarcinoma.
Tsokos CG, Krings G, Yilmaz F, Ferrell LD, Gill RM
Hum Pathol 2016 Nov;57:61-67. Epub 2016 Jul 7 doi: 10.1016/j.humpath.2016.06.019. PMID: 27396933Free PMC Article
Bile duct adenoma: a case report and literature review.
Chen L, Xu MY, Chen F
World J Surg Oncol 2014 Apr 26;12:125. doi: 10.1186/1477-7819-12-125. PMID: 24767257Free PMC Article
Cholangiocarcinoma complicating primary sclerosing cholangitis.
Rosen CB, Nagorney DM
Semin Liver Dis 1991 Feb;11(1):26-30. doi: 10.1055/s-2008-1040419. PMID: 1646485
Chemotherapy and radiotherapy of malignant hepatic tumours.
Forbes A, Williams R
Baillieres Clin Gastroenterol 1987 Jan;1(1):151-69. doi: 10.1016/0950-3528(87)90038-8. PMID: 3034357

Clinical prediction guides

Bile duct adenoma: imaging features and radiologic-pathologic correlation.
Tatsumi R, Ichihara S, Suii H, Yamaguchi M, Arakawa T, Nakajima T, Kuwata Y, Ozeki I, Hige S, Toyota J, Karino Y
Jpn J Radiol 2020 Jun;38(6):561-571. Epub 2020 Mar 3 doi: 10.1007/s11604-020-00938-0. PMID: 32128668
Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions.
Sasaki M, Nakanuma Y
Histol Histopathol 2015 Mar;30(3):267-75. Epub 2014 Oct 7 doi: 10.14670/HH-30.267. PMID: 25289642
Bile duct adenoma and von Meyenburg complex-like duct arising in hepatitis and cirrhosis: pathogenesis and histological characteristics.
Aishima S, Tanaka Y, Kubo Y, Shirabe K, Maehara Y, Oda Y
Pathol Int 2014 Nov;64(11):551-9. Epub 2014 Oct 20 doi: 10.1111/pin.12209. PMID: 25329860
Cholangiocarcinoma in hepatolithiasis.
Chen PH, Lo HW, Wang CS, Tsai KR, Chen YC, Lin KY, Siauw CP, Hwang RR, Liu MH, Ko HC
J Clin Gastroenterol 1984 Dec;6(6):539-47. doi: 10.1097/00004836-198412000-00010. PMID: 6096441
The cytoskeleton in tumor cells.
Bannasch P, Zerban H, Mayer D
Pathol Res Pract 1982;175(2-3):196-211. doi: 10.1016/S0344-0338(82)80108-8. PMID: 6304665

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