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Extrahepatic bile duct neoplasm

MedGen UID:
91056
•Concept ID:
C0345913
•
Neoplastic Process
Synonyms: Extrahepatic Bile Duct Neoplasm; extrahepatic bile duct neoplasm; extrahepatic bile duct neoplasm (disease); Extrahepatic Bile Duct Tumor; extrahepatic bile duct tumor; extrahepatic bile duct tumour; Neoplasm of Extrahepatic Bile Duct; neoplasm of extrahepatic bile duct; Neoplasm of extrahepatic bile ducts; Neoplasm of the Extrahepatic Bile Duct; neoplasm of the extrahepatic bile duct; Tumor of extrahepatic bile duct; Tumor of Extrahepatic Bile Duct; tumor of extrahepatic bile duct; Tumor of the Extrahepatic Bile Duct; tumor of the extrahepatic bile duct; tumour of extrahepatic bile duct; tumour of the extrahepatic bile duct
SNOMED CT: Neoplasm of extrahepatic bile ducts (126855001); Tumor of extrahepatic bile duct (126855001)
 
Monarch Initiative: MONDO:0021385

Definition

A benign or malignant neoplasm that affects the extrahepatic bile ducts. Representative examples include adenoma and adenocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVExtrahepatic bile duct neoplasm

Professional guidelines

PubMed

Diagnosis and management of choledochal cysts.
Brown ZJ, Baghdadi A, Kamel I, Labiner HE, Hewitt DB, Pawlik TM
HPB (Oxford) 2023 Jan;25(1):14-25. Epub 2022 Oct 5 doi: 10.1016/j.hpb.2022.09.010. PMID: 36257874
Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Hepatobiliary Cancers, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology.
Benson AB, D'Angelica MI, Abbott DE, Anaya DA, Anders R, Are C, Bachini M, Borad M, Brown D, Burgoyne A, Chahal P, Chang DT, Cloyd J, Covey AM, Glazer ES, Goyal L, Hawkins WG, Iyer R, Jacob R, Kelley RK, Kim R, Levine M, Palta M, Park JO, Raman S, Reddy S, Sahai V, Schefter T, Singh G, Stein S, Vauthey JN, Venook AP, Yopp A, McMillian NR, Hochstetler C, Darlow SD
J Natl Compr Canc Netw 2021 May 1;19(5):541-565. doi: 10.6004/jnccn.2021.0022. PMID: 34030131

Recent clinical studies

Etiology

Diagnosis and management of choledochal cysts.
Brown ZJ, Baghdadi A, Kamel I, Labiner HE, Hewitt DB, Pawlik TM
HPB (Oxford) 2023 Jan;25(1):14-25. Epub 2022 Oct 5 doi: 10.1016/j.hpb.2022.09.010. PMID: 36257874
Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA
J Hepatol 2020 Jan;72(1):95-103. Epub 2019 Sep 16 doi: 10.1016/j.jhep.2019.09.007. PMID: 31536748
Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma.
Bertuccio P, Malvezzi M, Carioli G, Hashim D, Boffetta P, El-Serag HB, La Vecchia C, Negri E
J Hepatol 2019 Jul;71(1):104-114. Epub 2019 Mar 23 doi: 10.1016/j.jhep.2019.03.013. PMID: 30910538
Cholangiocarcinoma--current treatment options.
Friman S
Scand J Surg 2011;100(1):30-4. doi: 10.1177/145749691110000106. PMID: 21491796

Diagnosis

Diagnosis and management of choledochal cysts.
Brown ZJ, Baghdadi A, Kamel I, Labiner HE, Hewitt DB, Pawlik TM
HPB (Oxford) 2023 Jan;25(1):14-25. Epub 2022 Oct 5 doi: 10.1016/j.hpb.2022.09.010. PMID: 36257874
Extrahepatic bile duct malignancies.
Třeška V, Fichtl J, Ferda J, Fínek J, Skalický T, Liška V, Hošek P
Rozhl Chir 2022 Fall;101(9):428-435. doi: 10.33699/PIS.2022.101.9.428-435. PMID: 36257801
Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma.
Bertuccio P, Malvezzi M, Carioli G, Hashim D, Boffetta P, El-Serag HB, La Vecchia C, Negri E
J Hepatol 2019 Jul;71(1):104-114. Epub 2019 Mar 23 doi: 10.1016/j.jhep.2019.03.013. PMID: 30910538
Cholangiocarcinoma.
Krasinskas AM
Surg Pathol Clin 2018 Jun;11(2):403-429. doi: 10.1016/j.path.2018.02.005. PMID: 29751883

Therapy

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA
J Hepatol 2020 Jan;72(1):95-103. Epub 2019 Sep 16 doi: 10.1016/j.jhep.2019.09.007. PMID: 31536748
Cholangiocellular Carcinoma.
Vogel A, Saborowski A
Digestion 2017;95(3):181-185. Epub 2017 Mar 14 doi: 10.1159/000454763. PMID: 28288474
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Ampullary cancer: an overview.
Ahn DH, Bekaii-Saab T
Am Soc Clin Oncol Educ Book 2014:112-5. doi: 10.14694/EdBook_AM.2014.34.112. PMID: 24857067Free PMC Article

Prognosis

Clinical treatment of cholangiocarcinoma: an updated comprehensive review.
Elvevi A, Laffusa A, Scaravaglio M, Rossi RE, Longarini R, Stagno AM, Cristoferi L, Ciaccio A, Cortinovis DL, Invernizzi P, Massironi S
Ann Hepatol 2022 Sep-Oct;27(5):100737. Epub 2022 Jul 7 doi: 10.1016/j.aohep.2022.100737. PMID: 35809836
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA
J Hepatol 2020 Jan;72(1):95-103. Epub 2019 Sep 16 doi: 10.1016/j.jhep.2019.09.007. PMID: 31536748
Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma.
Bertuccio P, Malvezzi M, Carioli G, Hashim D, Boffetta P, El-Serag HB, La Vecchia C, Negri E
J Hepatol 2019 Jul;71(1):104-114. Epub 2019 Mar 23 doi: 10.1016/j.jhep.2019.03.013. PMID: 30910538
Cholangiocarcinoma.
Krasinskas AM
Surg Pathol Clin 2018 Jun;11(2):403-429. doi: 10.1016/j.path.2018.02.005. PMID: 29751883
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article

Clinical prediction guides

Revolutionizing anti-HER2 therapies for extrahepatic cholangiocarcinoma and gallbladder cancer: Current advancements and future perspectives.
Ten Haaft BH, Pedregal M, Prato J, Klümpen HJ, Moreno V, Lamarca A
Eur J Cancer 2024 Mar;199:113564. Epub 2024 Jan 20 doi: 10.1016/j.ejca.2024.113564. PMID: 38266541
Asbestos and Intrahepatic Cholangiocarcinoma.
Brandi G, Tavolari S
Cells 2020 Feb 12;9(2) doi: 10.3390/cells9020421. PMID: 32059499Free PMC Article
Intrahepatic Cholangiocarcinoma.
El-Diwany R, Pawlik TM, Ejaz A
Surg Oncol Clin N Am 2019 Oct;28(4):587-599. doi: 10.1016/j.soc.2019.06.002. PMID: 31472907
Global trends in mortality from intrahepatic and extrahepatic cholangiocarcinoma.
Bertuccio P, Malvezzi M, Carioli G, Hashim D, Boffetta P, El-Serag HB, La Vecchia C, Negri E
J Hepatol 2019 Jul;71(1):104-114. Epub 2019 Mar 23 doi: 10.1016/j.jhep.2019.03.013. PMID: 30910538
SWOG S0809: A Phase II Intergroup Trial of Adjuvant Capecitabine and Gemcitabine Followed by Radiotherapy and Concurrent Capecitabine in Extrahepatic Cholangiocarcinoma and Gallbladder Carcinoma.
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article

Recent systematic reviews

Cholangiocarcinoma Attributed to Occupation: A Systematic Reviews.
Seeherunwong A, Chaiear N, Khuntikeo N, Ekpanyaskul C
Asian Pac J Cancer Prev 2022 Jun 1;23(6):1837-1845. doi: 10.31557/APJCP.2022.23.6.1837. PMID: 35763622Free PMC Article
Risk factors for intrahepatic and extrahepatic cholangiocarcinoma: A systematic review and meta-analysis.
Clements O, Eliahoo J, Kim JU, Taylor-Robinson SD, Khan SA
J Hepatol 2020 Jan;72(1):95-103. Epub 2019 Sep 16 doi: 10.1016/j.jhep.2019.09.007. PMID: 31536748
Neuroendocrine tumors of extrahepatic biliary tract.
Michalopoulos N, Papavramidis TS, Karayannopoulou G, Pliakos I, Papavramidis ST, Kanellos I
Pathol Oncol Res 2014 Oct;20(4):765-75. Epub 2014 Jun 11 doi: 10.1007/s12253-014-9808-4. PMID: 24917351
Treatment and Prognosis for Patients With Intrahepatic Cholangiocarcinoma: Systematic Review and Meta-analysis.
Mavros MN, Economopoulos KP, Alexiou VG, Pawlik TM
JAMA Surg 2014 Jun;149(6):565-74. doi: 10.1001/jamasurg.2013.5137. PMID: 24718873
Chemoradiation and brachytherapy in extrahepatic bile duct carcinoma.
Mattiucci GC, Autorino R, D'Agostino GR, Deodato F, Macchia G, Perri V, Tringali A, Morganti AG, Mutignani M, Valentini V
Crit Rev Oncol Hematol 2014 Apr;90(1):58-67. Epub 2013 Nov 2 doi: 10.1016/j.critrevonc.2013.10.007. PMID: 24289902

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