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Fibroepithelial neoplasm

MedGen UID:
104908
•Concept ID:
C0206649
•
Neoplastic Process
Synonyms: Fibroepithelial Neoplasm; Fibroepithelial Neoplasms; Neoplasm, Fibroepithelial; Neoplasms, Fibroepithelial
SNOMED CT: Fibroepithelial neoplasm (115230008)
 
Monarch Initiative: MONDO:0021045

Definition

A benign, borderline, or malignant neoplasm characterized by the presence of an epithelial and a fibrous component. Representative examples are fibroadenoma and phyllodes tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVFibroepithelial neoplasm

Professional guidelines

PubMed

Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571

Recent clinical studies

Etiology

Recurrence is Not Associated with Margin Status in Phyllodes Tumor.
Yoon KH, Kang E, Kim EK, Park SY, Shin HC
Ann Surg Oncol 2023 Apr;30(4):2154-2161. Epub 2023 Jan 3 doi: 10.1245/s10434-022-12997-w. PMID: 36596955
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Cystosarcoma phyllodes: Pathological enigma: A retrospective review of 162 cases.
Narayanakar RP, Gangaiah DM, Althaf S, Dev K, Kurpad V, Gurawalia J
Indian J Cancer 2015 Jul-Sep;52(3):365-8. doi: 10.4103/0019-509X.176698. PMID: 26905140
Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012.
Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. PMID: 23533258
Phyllodes tumor of the breast.
Belkacémi Y, Bousquet G, Marsiglia H, Ray-Coquard I, Magné N, Malard Y, Lacroix M, Gutierrez C, Senkus E, Christie D, Drumea K, Lagneau E, Kadish SP, Scandolaro L, Azria D, Ozsahin M
Int J Radiat Oncol Biol Phys 2008 Feb 1;70(2):492-500. Epub 2007 Oct 10 doi: 10.1016/j.ijrobp.2007.06.059. PMID: 17931796

Diagnosis

Genomic characterisation of breast fibroepithelial lesions in an international cohort.
Md Nasir ND, Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VKM, Wong CY, Yong WS, Ho GH, Ong KW; International Fibroepithelial Consortium, Tan P, Teh BT, Tan PH
J Pathol 2019 Dec;249(4):447-460. Epub 2019 Oct 8 doi: 10.1002/path.5333. PMID: 31411343
Pediatric breast masses: an argument for observation.
McLaughlin CM, Gonzalez-Hernandez J, Bennett M, Piper HG
J Surg Res 2018 Aug;228:247-252. Epub 2018 Apr 12 doi: 10.1016/j.jss.2018.03.056. PMID: 29907218
Phyllodes Tumor of the Breast: Histopathologic Features, Differential Diagnosis, and Molecular/Genetic Updates.
Zhang Y, Kleer CG
Arch Pathol Lab Med 2016 Jul;140(7):665-71. doi: 10.5858/arpa.2016-0042-RA. PMID: 27362571
Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012.
Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. PMID: 23533258
Phyllodes tumors of the breast.
Khan SA, Badve S
Curr Treat Options Oncol 2001 Apr;2(2):139-47. doi: 10.1007/s11864-001-0056-y. PMID: 12057132

Therapy

A Case of Benign Phyllodes Tumor in a Transgender Woman Receiving Cross-Sex Hormones.
Richards SM, Pine-Twaddell ED, Ioffe OB, Bellavance EC
Int J Surg Pathol 2018 Jun;26(4):356-359. Epub 2017 Nov 23 doi: 10.1177/1066896917743011. PMID: 29169272
Phyllodes tumors of the breast.
Khan SA, Badve S
Curr Treat Options Oncol 2001 Apr;2(2):139-47. doi: 10.1007/s11864-001-0056-y. PMID: 12057132

Prognosis

Recurrence is Not Associated with Margin Status in Phyllodes Tumor.
Yoon KH, Kang E, Kim EK, Park SY, Shin HC
Ann Surg Oncol 2023 Apr;30(4):2154-2161. Epub 2023 Jan 3 doi: 10.1245/s10434-022-12997-w. PMID: 36596955
Genomic characterisation of breast fibroepithelial lesions in an international cohort.
Md Nasir ND, Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VKM, Wong CY, Yong WS, Ho GH, Ong KW; International Fibroepithelial Consortium, Tan P, Teh BT, Tan PH
J Pathol 2019 Dec;249(4):447-460. Epub 2019 Oct 8 doi: 10.1002/path.5333. PMID: 31411343
Cystosarcoma phyllodes: Pathological enigma: A retrospective review of 162 cases.
Narayanakar RP, Gangaiah DM, Althaf S, Dev K, Kurpad V, Gurawalia J
Indian J Cancer 2015 Jul-Sep;52(3):365-8. doi: 10.4103/0019-509X.176698. PMID: 26905140
Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012.
Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. PMID: 23533258
Phyllodes tumors of the breast.
Khan SA, Badve S
Curr Treat Options Oncol 2001 Apr;2(2):139-47. doi: 10.1007/s11864-001-0056-y. PMID: 12057132

Clinical prediction guides

Clinical presentation and radiologic imaging findings of phyllodes tumors: benign and borderline/malignant phyllodes tumors.
Lohitvisate W, Rodjanakonkiat K, Kwankua A
F1000Res 2024;13:210. Epub 2024 May 28 doi: 10.12688/f1000research.145872.2. PMID: 38845824Free PMC Article
RB1 loss in the mesenchymal component of onychomatricoma.
Liu Y, Zou D, Huang Q, Wang L
J Cutan Pathol 2023 Dec;50(12):1094-1098. Epub 2023 Aug 19 doi: 10.1111/cup.14514. PMID: 37596842
Genomic characterisation of breast fibroepithelial lesions in an international cohort.
Md Nasir ND, Ng CCY, Rajasegaran V, Wong SF, Liu W, Ng GXP, Lee JY, Guan P, Lim JQ, Thike AA, Koh VCY, Loke BN, Chang KTE, Gudi MA, Lian DWQ, Madhukumar P, Tan BKT, Tan VKM, Wong CY, Yong WS, Ho GH, Ong KW; International Fibroepithelial Consortium, Tan P, Teh BT, Tan PH
J Pathol 2019 Dec;249(4):447-460. Epub 2019 Oct 8 doi: 10.1002/path.5333. PMID: 31411343
Pediatric breast masses: an argument for observation.
McLaughlin CM, Gonzalez-Hernandez J, Bennett M, Piper HG
J Surg Res 2018 Aug;228:247-252. Epub 2018 Apr 12 doi: 10.1016/j.jss.2018.03.056. PMID: 29907218
Myoepithelial and epithelial-myoepithelial, mesenchymal and fibroepithelial breast lesions: updates from the WHO Classification of Tumours of the Breast 2012.
Tan PH, Ellis IO
J Clin Pathol 2013 Jun;66(6):465-70. Epub 2013 Mar 26 doi: 10.1136/jclinpath-2012-201078. PMID: 23533258

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