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Clear cell adenofibroma

MedGen UID:
90762
•Concept ID:
C0334317
•
Neoplastic Process
Synonyms: Cystadenofibroma; Cystadenofibromas
 
Monarch Initiative: MONDO:0003460

Definition

A benign or borderline neoplasm that arises from the ovaries and the fallopian tubes. It is characterized by the presence of cystic glandular structures and fibrous tissue. [from NCI]

Professional guidelines

PubMed

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Recent clinical studies

Etiology

Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Loss of ARID1A protein expression occurs as an early event in ovarian clear-cell carcinoma development and frequently coexists with PIK3CA mutations.
Yamamoto S, Tsuda H, Takano M, Tamai S, Matsubara O
Mod Pathol 2012 Apr;25(4):615-24. Epub 2011 Dec 9 doi: 10.1038/modpathol.2011.189. PMID: 22157930
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822

Diagnosis

Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Borderline clear cell adenofibroma of the ovary associated with ovarian endometriosis: a case report.
Vasilakaki T, Skafida E, Arkoumani E, Grammatoglou X, Firfiris N, Manoloudaki K
Eur J Gynaecol Oncol 2012;33(2):230-2. PMID: 22611972
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822

Therapy

Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article

Prognosis

Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Clear cell carcinoma of the ovary: is there a role of histology-specific treatment?
Takano M, Tsuda H, Sugiyama T
J Exp Clin Cancer Res 2012 Jun 1;31(1):53. doi: 10.1186/1756-9966-31-53. PMID: 22655678Free PMC Article
Borderline clear cell adenofibroma with extensive hemorrhagic necrosis.
Liu JL, Chu PY, Yeh KT, Huang RH
Hematol Oncol Stem Cell Ther 2010;3(3):158-60. doi: 10.1016/s1658-3876(10)50026-8. PMID: 20890073
Benign clear cell adenofibroma of the ovary. A case report with literature review.
Paşaoğlu O, Ciftçi E, Tel N, Ozalp S, Acikalin MF
Gynecol Obstet Invest 2007;64(1):36-9. Epub 2007 Jan 5 doi: 10.1159/000098425. PMID: 17202822
Ovarian clear cell adenofibromatous tumors. Benign, of low malignant potential, and associated with invasive clear cell carcinoma.
Roth LM, Langley FA, Fox H, Wheeler JE, Czernobilsky B
Cancer 1984 Mar 1;53(5):1156-63. doi: 10.1002/1097-0142(19840301)53:5<1156::aid-cncr2820530522>3.0.co;2-2. PMID: 6692303

Clinical prediction guides

Pathologic Findings in Prophylactic and Nonprophylactic Hysterectomy Specimens of Patients With Lynch Syndrome.
Bartosch C, Pires-Luís AS, Meireles C, Baptista M, Gouveia A, Pinto C, Shannon KM, Jerónimo C, Teixeira MR, Lopes JM, Oliva E
Am J Surg Pathol 2016 Sep;40(9):1177-91. doi: 10.1097/PAS.0000000000000684. PMID: 27340747
Clear cell carcinoma of the ovary: comparison of MR findings of histological subtypes.
Kato H, Hatano Y, Makino H, Furui T, Morishige KI, Matsuo M
Abdom Radiol (NY) 2016 Dec;41(12):2476-2483. doi: 10.1007/s00261-016-0777-9. PMID: 27167231
Napsin A is a specific marker for ovarian clear cell adenocarcinoma.
Yamashita Y, Nagasaka T, Naiki-Ito A, Sato S, Suzuki S, Toyokuni S, Ito M, Takahashi S
Mod Pathol 2015 Jan;28(1):111-7. Epub 2014 Apr 11 doi: 10.1038/modpathol.2014.61. PMID: 24721826
Ovarian benign clear cell adenofibroma in a patient with premature ovarian failure after 8-year hormone replacement therapy.
Chen R, Zhou H, Zhang Y
Gynecol Endocrinol 2013 Mar;29(3):216-8. Epub 2012 Nov 16 doi: 10.3109/09513590.2012.736555. PMID: 23153077
PIK3CA mutations and loss of ARID1A protein expression are early events in the development of cystic ovarian clear cell adenocarcinoma.
Yamamoto S, Tsuda H, Takano M, Tamai S, Matsubara O
Virchows Arch 2012 Jan;460(1):77-87. Epub 2011 Nov 26 doi: 10.1007/s00428-011-1169-8. PMID: 22120431

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