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Nerve sheath neoplasm

MedGen UID:
64639
•Concept ID:
C0206727
•
Neoplastic Process
Synonyms: Neoplasm, Nerve Sheath; Neoplasms, Nerve Sheath; Nerve Sheath Neoplasm; Nerve Sheath Neoplasms; Nerve Sheath Tumor; Nerve Sheath Tumors; Sheath Tumor, Nerve; Sheath Tumors, Nerve; Tumor, Nerve Sheath; Tumors of the Nerve Sheath; Tumors, Nerve Sheath
SNOMED CT: Nerve sheath tumor (115242003)
 
Monarch Initiative: MONDO:0002547

Definition

A benign or malignant neoplasm arising from the perineural cells in the sheaths surrounding the nerves. Representative examples include neurofibroma, schwannoma, and malignant peripheral nerve sheath tumor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNerve sheath neoplasm

Professional guidelines

PubMed

Revised diagnostic criteria for neurofibromatosis type 1 and Legius syndrome: an international consensus recommendation.
Legius E, Messiaen L, Wolkenstein P, Pancza P, Avery RA, Berman Y, Blakeley J, Babovic-Vuksanovic D, Cunha KS, Ferner R, Fisher MJ, Friedman JM, Gutmann DH, Kehrer-Sawatzki H, Korf BR, Mautner VF, Peltonen S, Rauen KA, Riccardi V, Schorry E, Stemmer-Rachamimov A, Stevenson DA, Tadini G, Ullrich NJ, Viskochil D, Wimmer K, Yohay K; International Consensus Group on Neurofibromatosis Diagnostic Criteria (I-NF-DC), Huson SM, Evans DG, Plotkin SR
Genet Med 2021 Aug;23(8):1506-1513. Epub 2021 May 19 doi: 10.1038/s41436-021-01170-5. PMID: 34012067Free PMC Article
EANO guideline on the diagnosis and treatment of vestibular schwannoma.
Goldbrunner R, Weller M, Regis J, Lund-Johansen M, Stavrinou P, Reuss D, Evans DG, Lefranc F, Sallabanda K, Falini A, Axon P, Sterkers O, Fariselli L, Wick W, Tonn JC
Neuro Oncol 2020 Jan 11;22(1):31-45. doi: 10.1093/neuonc/noz153. PMID: 31504802Free PMC Article
The Diagnosis and Management of Neurofibromatosis Type 1.
Ly KI, Blakeley JO
Med Clin North Am 2019 Nov;103(6):1035-1054. doi: 10.1016/j.mcna.2019.07.004. PMID: 31582003

Recent clinical studies

Etiology

Breast Shwannoma - Time to explore alternative management strategy?
Ashoor A, Lissidini G, Girardi A, Mirza M, Baig MS
Ann Diagn Pathol 2021 Oct;54:151773. Epub 2021 Jun 21 doi: 10.1016/j.anndiagpath.2021.151773. PMID: 34273600
Reverse adipofascial flap after resection of a malignant perineurioma of the forearm.
Takahashi M, Kasai T, Nishisho T, Takai M, Endo H, Hirose T, Sairyo K
Orthopedics 2014 Jul;37(7):e661-4. doi: 10.3928/01477447-20140626-65. PMID: 24992065
Peripheral tumor and tumor-like neurogenic lesions.
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A
Eur J Radiol 2013 Jan;82(1):38-50. Epub 2011 May 10 doi: 10.1016/j.ejrad.2011.04.036. PMID: 21561733
Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series.
Strom T, Kleinschmidt-Demasters BK, Donson A, Foreman NK, Lillehei KO
Arch Pathol Lab Med 2009 Sep;133(9):1391-402. doi: 10.5858/133.9.1391. PMID: 19722745
Psammomatous malignant melanoma arising in an intradermal naevus.
Monteagudo C, Ferrández A, González-Devesa M, Llombart-Bosch A
Histopathology 2001 Nov;39(5):493-7. doi: 10.1046/j.1365-2559.2001.01280.x. PMID: 11737307

Diagnosis

Schwannoma of the tongue.
Kavčič J, Božič M
BMJ Case Rep 2016 Oct 8;2016 doi: 10.1136/bcr-2016-215799. PMID: 28049116Free PMC Article
Peripheral tumor and tumor-like neurogenic lesions.
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A
Eur J Radiol 2013 Jan;82(1):38-50. Epub 2011 May 10 doi: 10.1016/j.ejrad.2011.04.036. PMID: 21561733
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Rare nerve lesions of non-nerve sheath origin: a 17-year retrospective series.
Strom T, Kleinschmidt-Demasters BK, Donson A, Foreman NK, Lillehei KO
Arch Pathol Lab Med 2009 Sep;133(9):1391-402. doi: 10.5858/133.9.1391. PMID: 19722745
Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm.
Macarenco RS, Ellinger F, Oliveira AM
Arch Pathol Lab Med 2007 Apr;131(4):625-36. doi: 10.5858/2007-131-625-PADAUP. PMID: 17425397

Therapy

18F-FDG PET/CT imaging for aggressive melanotic schwannoma of the L3 spinal root: A case report.
Shen XZ, Wang W, Luo ZY
Medicine (Baltimore) 2021 Feb 26;100(8):e24803. doi: 10.1097/MD.0000000000024803. PMID: 33663098Free PMC Article
Melanotic schwannoma of the cervical spine progressing with pulmonary metastasis: case report.
Faria MH, Dória-Netto RH, Osugue GJ, Queiroz Lde S, Chaddad-Neto FE
Neurol Med Chir (Tokyo) 2013;53(10):712-6. Epub 2013 Sep 27 doi: 10.2176/nmc.cr2012-0203. PMID: 24077273Free PMC Article
Successful resection of a primary left ventricular schwannoma.
La Francesca S, Gregoric ID, Cohn WE, Frazier OH
Ann Thorac Surg 2007 May;83(5):1881-2. doi: 10.1016/j.athoracsur.2006.12.012. PMID: 17462424

Prognosis

18F-FDG PET/CT imaging for aggressive melanotic schwannoma of the L3 spinal root: A case report.
Shen XZ, Wang W, Luo ZY
Medicine (Baltimore) 2021 Feb 26;100(8):e24803. doi: 10.1097/MD.0000000000024803. PMID: 33663098Free PMC Article
Melanotic schwannoma of the cervical spine progressing with pulmonary metastasis: case report.
Faria MH, Dória-Netto RH, Osugue GJ, Queiroz Lde S, Chaddad-Neto FE
Neurol Med Chir (Tokyo) 2013;53(10):712-6. Epub 2013 Sep 27 doi: 10.2176/nmc.cr2012-0203. PMID: 24077273Free PMC Article
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Perineurioma: a distinctive and underrecognized peripheral nerve sheath neoplasm.
Macarenco RS, Ellinger F, Oliveira AM
Arch Pathol Lab Med 2007 Apr;131(4):625-36. doi: 10.5858/2007-131-625-PADAUP. PMID: 17425397

Clinical prediction guides

Breast Shwannoma - Time to explore alternative management strategy?
Ashoor A, Lissidini G, Girardi A, Mirza M, Baig MS
Ann Diagn Pathol 2021 Oct;54:151773. Epub 2021 Jun 21 doi: 10.1016/j.anndiagpath.2021.151773. PMID: 34273600
Tongue Schwannoma: A Clinicopathologic Study of 19 Cases.
Thompson LDR, Koh SS, Lau SK
Head Neck Pathol 2020 Sep;14(3):571-576. Epub 2019 Sep 4 doi: 10.1007/s12105-019-01071-9. PMID: 31485983Free PMC Article
Peripheral tumor and tumor-like neurogenic lesions.
Abreu E, Aubert S, Wavreille G, Gheno R, Canella C, Cotten A
Eur J Radiol 2013 Jan;82(1):38-50. Epub 2011 May 10 doi: 10.1016/j.ejrad.2011.04.036. PMID: 21561733
Intravascular schwannoma.
Gaudi S, Mills O, Goyette EF, Morgan MB
Am J Dermatopathol 2011 Dec;33(8):850-4. doi: 10.1097/DAD.0b013e3181f5df90. PMID: 22042258
Human peripheral nerve sheath neoplasm: expression of Schwann cell-related markers and their relation to malignant transformation.
Yasuda T, Sobue G, Ito T, Doyu M, Sugiura I, Hashizume Y, Kato K
Muscle Nerve 1991 Sep;14(9):812-9. doi: 10.1002/mus.880140903. PMID: 1656253

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