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Benign Gastric Granular Cell Tumor

MedGen UID:
231429
•Concept ID:
C1332503
•
Neoplastic Process
Synonyms: Benign Gastric Granular Cell Neoplasm; Benign Granular Cell Neoplasm of Stomach; Benign Granular Cell Neoplasm of the Stomach; Benign Granular Cell Stomach Neoplasm; Benign Granular Cell Stomach Tumor; Benign Granular Cell Tumor of Stomach; Benign Granular Cell Tumor of the Stomach; Gastric Myoblastoma; Myoblastoma of Stomach; Myoblastoma of the Stomach

Definition

A granular cell tumor that arises from the stomach and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBenign Gastric Granular Cell Tumor

Professional guidelines

PubMed

Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797

Recent clinical studies

Etiology

Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.
Shaheen M, Wilkins BJ, Shenoy A, Byrnes K, Zhang XT, González IA
Pediatr Dev Pathol 2024 May-Jun;27(3):211-217. Epub 2024 Jan 5 doi: 10.1177/10935266231220472. PMID: 38179814
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
A clinicopathologic study of esophageal 860 benign and malignant lesions in 910 cases of consecutive esophageal biopsies.
Terada T
Int J Clin Exp Pathol 2013;6(2):191-8. Epub 2013 Jan 15 PMID: 23330004Free PMC Article
Four cases of patients with gastrointestinal granular cell tumors.
Lowe DL, Chaudhary AJ, Lee JR, Chamberlain SM, Schade RR, Cuartas-Hoyos U
South Med J 2007 Mar;100(3):298-300. doi: 10.1097/SMJ.0b013e318030eeff. PMID: 17396735
Leiomyoma of the oral cavity: a light microscopic and immunohistochemical study with review of the literature from 1884 to 1992.
Baden E, Doyle JL, Lederman DA
Eur J Cancer B Oral Oncol 1994 Jan;30B(1):1-7. doi: 10.1016/0964-1955(94)90043-4. PMID: 9135966

Diagnosis

Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.
Shaheen M, Wilkins BJ, Shenoy A, Byrnes K, Zhang XT, González IA
Pediatr Dev Pathol 2024 May-Jun;27(3):211-217. Epub 2024 Jan 5 doi: 10.1177/10935266231220472. PMID: 38179814
Endoscopic management of subepithelial lesions including neuroendocrine neoplasms: European Society of Gastrointestinal Endoscopy (ESGE) Guideline.
Deprez PH, Moons LMG, OʼToole D, Gincul R, Seicean A, Pimentel-Nunes P, Fernández-Esparrach G, Polkowski M, Vieth M, Borbath I, Moreels TG, Nieveen van Dijkum E, Blay JY, van Hooft JE
Endoscopy 2022 Apr;54(4):412-429. Epub 2022 Feb 18 doi: 10.1055/a-1751-5742. PMID: 35180797
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital.
Jobrack AD, Goel S, Cotlar AM
Mil Med 2018 Sep 1;183(9-10):e589-e593. doi: 10.1093/milmed/usx237. PMID: 29548015
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
From the radiologic pathology archives: esophageal neoplasms: radiologic-pathologic correlation.
Lewis RB, Mehrotra AK, Rodriguez P, Levine MS
Radiographics 2013 Jul-Aug;33(4):1083-108. doi: 10.1148/rg.334135027. PMID: 23842973

Prognosis

Gastrointestinal Tract Granular Cell Tumor in the Pediatric Population: A Multicenter Experience.
Shaheen M, Wilkins BJ, Shenoy A, Byrnes K, Zhang XT, González IA
Pediatr Dev Pathol 2024 May-Jun;27(3):211-217. Epub 2024 Jan 5 doi: 10.1177/10935266231220472. PMID: 38179814
Granular Cell Tumor: Report of 13 Cases in a Veterans Administration Hospital.
Jobrack AD, Goel S, Cotlar AM
Mil Med 2018 Sep 1;183(9-10):e589-e593. doi: 10.1093/milmed/usx237. PMID: 29548015
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
Four cases of patients with gastrointestinal granular cell tumors.
Lowe DL, Chaudhary AJ, Lee JR, Chamberlain SM, Schade RR, Cuartas-Hoyos U
South Med J 2007 Mar;100(3):298-300. doi: 10.1097/SMJ.0b013e318030eeff. PMID: 17396735
Leiomyoma of the oral cavity: a light microscopic and immunohistochemical study with review of the literature from 1884 to 1992.
Baden E, Doyle JL, Lederman DA
Eur J Cancer B Oral Oncol 1994 Jan;30B(1):1-7. doi: 10.1016/0964-1955(94)90043-4. PMID: 9135966

Clinical prediction guides

Granular cell tumor of the gastrointestinal tract: histologic and immunohistochemical analysis of 98 cases.
An S, Jang J, Min K, Kim MS, Park H, Park YS, Kim J, Lee JH, Song HJ, Kim KJ, Yu E, Hong SM
Hum Pathol 2015 Jun;46(6):813-9. Epub 2015 Feb 26 doi: 10.1016/j.humpath.2015.02.005. PMID: 25882927
Benign esophageal lesions: endoscopic and pathologic features.
Tsai SJ, Lin CC, Chang CW, Hung CY, Shieh TY, Wang HY, Shih SC, Chen MJ
World J Gastroenterol 2015 Jan 28;21(4):1091-8. doi: 10.3748/wjg.v21.i4.1091. PMID: 25632181Free PMC Article
PEComa of the gastrointestinal tract: clinicopathologic study of 35 cases with evaluation of prognostic parameters.
Doyle LA, Hornick JL, Fletcher CD
Am J Surg Pathol 2013 Dec;37(12):1769-82. doi: 10.1097/PAS.0b013e31829caab3. PMID: 24061520
Combined granular cell tumour of the oesophagus and stomach: a case report and review of the literature.
Blandamura S, Altavilla G, Castoro C, Antonini C, Piazza M
Ital J Gastroenterol 1993 Jun;25(5):259-64. PMID: 8353300
Insulinoma. An immunocytochemical and morphologic analysis of 95 cases.
Liu TH, Tseng HC, Zhu Y, Zhong SX, Chen J, Cui QC
Cancer 1985 Sep 15;56(6):1420-9. doi: 10.1002/1097-0142(19850915)56:6<1420::aid-cncr2820560633>3.0.co;2-y. PMID: 2992737

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