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Cardiac granular cell neoplasm

MedGen UID:
232023
•Concept ID:
C1332845
•
Neoplastic Process
Synonyms: Cardiac Granular Cell Neoplasm; cardiac granular cell neoplasm; Cardiac Granular Cell Tumor; Cardiac granular cell tumor; Cardiac granular cell tumour; Granular Cell Neoplasm of Heart; granular cell neoplasm of heart; Granular Cell Neoplasm of the Heart; granular cell neoplasm of the heart; Granular Cell Tumor of Heart; granular cell tumor of heart; Granular Cell Tumor of the Heart; granular cell tumor of the heart; granular cell tumour of heart; granular cell tumour of the heart; Heart Granular Cell Tumor; heart granular cell tumor; heart granular cell tumour
 
Monarch Initiative: MONDO:0003254

Definition

A very rare granular cell tumor that arises from the heart. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCardiac granular cell neoplasm

Recent clinical studies

Etiology

Non-small cell lung cancer in never- and ever-smokers: Is it the same disease?
Tang A, Ahmad U, Toth AJ, Bourdakos N, Raja S, Raymond DP, Blackstone EH, Murthy SC
J Thorac Cardiovasc Surg 2021 Jun;161(6):1903-1917.e9. Epub 2020 Jun 18 doi: 10.1016/j.jtcvs.2020.03.175. PMID: 32893009Free PMC Article
The Role of Mast Cells in IgE-Independent Lung Diseases.
Komi DEA, Mortaz E, Amani S, Tiotiu A, Folkerts G, Adcock IM
Clin Rev Allergy Immunol 2020 Jun;58(3):377-387. doi: 10.1007/s12016-020-08779-5. PMID: 32086776Free PMC Article
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8(+) TCR-Vβ(+) expansions.
Lissina A, McLaren JE, Ilander M, Andersson EI, Lewis CS, Clement M, Herman A, Ladell K, Llewellyn-Lacey S, Miners KL, Gostick E, Melenhorst JJ, Barrett AJ, Price DA, Mustjoki S, Wooldridge L
Sci Rep 2018 Feb 7;8(1):2534. doi: 10.1038/s41598-017-18062-x. PMID: 29416058Free PMC Article
The ultrastructure of cardiac myxoma.
Williams WJ, Jenkins D, Erasmus D
Thorax 1970 Nov;25(6):756-61. doi: 10.1136/thx.25.6.756. PMID: 5494685Free PMC Article

Diagnosis

Inclusion Body Myositis and Neoplasia: A Narrative Review.
Damian L, Login CC, Solomon C, Belizna C, Encica S, Urian L, Jurcut C, Stancu B, Vulturar R
Int J Mol Sci 2022 Jul 1;23(13) doi: 10.3390/ijms23137358. PMID: 35806366Free PMC Article
Cytologic and histological features of rare nonepithelial and nonlymphoid tumors of the thyroid.
Rossi ED, Pantanowitz L, Hornick JL
Cancer Cytopathol 2021 Aug;129(8):583-602. Epub 2021 Jan 25 doi: 10.1002/cncy.22404. PMID: 33493367
Large Granular Lymphocyte Leukemia and Precapillary Pulmonary Hypertension.
Cherel B, Humbert M, LeBlanc FR, Zambello R, Hamidou M, Lifermann F, Montani D, Leoncin M, Decaux O, Pastoret C, Le Bourgeois A, Dominique S, Chabanne C, Loughran TP Jr, Lamy T
Chest 2020 Dec;158(6):2602-2609. Epub 2020 Sep 10 doi: 10.1016/j.chest.2020.07.094. PMID: 32919988
Cytologic Diagnosis of Oncocytic Neoplasms of the Thyroid Gland: The Importance of the Clinical Scenario.
Straccia P, Santeusanio G, Pierconti F, Brunelli C, Fadda G
Appl Immunohistochem Mol Morphol 2019 Nov/Dec;27(10):726-731. doi: 10.1097/PAI.0000000000000713. PMID: 30358610
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article

Therapy

Group 5 Pulmonary Hypertension Associated With T-Cell Large Granular Lymphocytic Leukemia: Hemodynamics and Treatment.
Strick DJ, Farber HW, Hill NS, Preston IR, Pradhan NM, Malla B
Chest 2024 Jul;166(1):e1-e3. doi: 10.1016/j.chest.2024.01.046. PMID: 38986644
Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
Non-small cell lung cancer in never- and ever-smokers: Is it the same disease?
Tang A, Ahmad U, Toth AJ, Bourdakos N, Raja S, Raymond DP, Blackstone EH, Murthy SC
J Thorac Cardiovasc Surg 2021 Jun;161(6):1903-1917.e9. Epub 2020 Jun 18 doi: 10.1016/j.jtcvs.2020.03.175. PMID: 32893009Free PMC Article
Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8(+) TCR-Vβ(+) expansions.
Lissina A, McLaren JE, Ilander M, Andersson EI, Lewis CS, Clement M, Herman A, Ladell K, Llewellyn-Lacey S, Miners KL, Gostick E, Melenhorst JJ, Barrett AJ, Price DA, Mustjoki S, Wooldridge L
Sci Rep 2018 Feb 7;8(1):2534. doi: 10.1038/s41598-017-18062-x. PMID: 29416058Free PMC Article
Alemtuzumab in T-cell large granular lymphocytic leukaemia: interim results from a single-arm, open-label, phase 2 study.
Dumitriu B, Ito S, Feng X, Stephens N, Yunce M, Kajigaya S, Melenhorst JJ, Rios O, Scheinberg P, Chinian F, Keyvanfar K, Battiwalla M, Wu CO, Maric I, Xi L, Raffeld M, Muranski P, Townsley DM, Young NS, Barrett AJ, Scheinberg P
Lancet Haematol 2016 Jan;3(1):e22-9. Epub 2015 Dec 17 doi: 10.1016/S2352-3026(15)00227-6. PMID: 26765645Free PMC Article

Prognosis

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
Neonatal cardiogenic shock revealing obstructive cardiac Hibernoma: case report.
Gribaa R, Kacem M, Ouannes S, Majdoub W, Thabet H, Ali IB, Elheraiche A, Slim M, Hmissa S, Neffati E, Cherif T, Kortas C, Marah J, Jerbi S
J Cardiothorac Surg 2021 Aug 4;16(1):222. doi: 10.1186/s13019-021-01582-z. PMID: 34348738Free PMC Article
Coexistence of amyloidosis and light chain deposition disease in the heart.
Sobue Y, Takemura G, Kawamura S, Yano T, Kanamori H, Morimoto SI, Matsuo H
Cardiovasc Pathol 2021 Mar-Apr;51:107315. Epub 2020 Nov 29 doi: 10.1016/j.carpath.2020.107315. PMID: 33264681
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Diagnostic approach to cardiac amyloidosis.
Amin HZ, Mori S, Sasaki N, Hirata K
Kobe J Med Sci 2014 Jun 18;60(1):E5-E11. PMID: 25011639

Clinical prediction guides

Single-cell RNA sequencing coupled to TCR profiling of large granular lymphocyte leukemia T cells.
Gao S, Wu Z, Arnold B, Diamond C, Batchu S, Giudice V, Alemu L, Raffo DQ, Feng X, Kajigaya S, Barrett J, Ito S, Young NS
Nat Commun 2022 Apr 11;13(1):1982. doi: 10.1038/s41467-022-29175-x. PMID: 35411048Free PMC Article
Coexistence of amyloidosis and light chain deposition disease in the heart.
Sobue Y, Takemura G, Kawamura S, Yano T, Kanamori H, Morimoto SI, Matsuo H
Cardiovasc Pathol 2021 Mar-Apr;51:107315. Epub 2020 Nov 29 doi: 10.1016/j.carpath.2020.107315. PMID: 33264681
Non-small cell lung cancer in never- and ever-smokers: Is it the same disease?
Tang A, Ahmad U, Toth AJ, Bourdakos N, Raja S, Raymond DP, Blackstone EH, Murthy SC
J Thorac Cardiovasc Surg 2021 Jun;161(6):1903-1917.e9. Epub 2020 Jun 18 doi: 10.1016/j.jtcvs.2020.03.175. PMID: 32893009Free PMC Article
Cardiac paragangliomas: A case series with clinicopathologic features and succinate dehydrogenase B immunostaining.
Alakeel F, Al Sannaa G, Ibarra-Cortez SH, Reardon MJ, Czerniak B, Chan EY, Ro J
Ann Diagn Pathol 2020 Apr;45:151477. Epub 2020 Feb 5 doi: 10.1016/j.anndiagpath.2020.151477. PMID: 32062474
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article

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