U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Sinonasal Spindle Cell Squamous Cell Carcinoma

MedGen UID:
1734714
•Concept ID:
C5420024
•
Neoplastic Process
Synonyms: Nasal Cavity and Paranasal Sinus Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma; Nasal Cavity and Paranasal Sinus Spindle Cell Squamous Cell Carcinoma; Sinonasal Spindle Cell (Sarcomatoid) Squamous Cell Carcinoma

Definition

A poorly differentiated squamous cell carcinoma arising from the sinonasal tract. It is characterized by the presence of malignant cells with spindle cell features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSinonasal Spindle Cell Squamous Cell Carcinoma

Professional guidelines

PubMed

Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article

Recent clinical studies

Etiology

Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.
Ackall FY, Issa K, Barak I, Teitelbaum J, Jang DW, Jung SH, Goldstein B, Carrau R, Abi Hachem R
Laryngoscope 2021 Apr;131(4):E1040-E1048. Epub 2020 Sep 22 doi: 10.1002/lary.29090. PMID: 32959912
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Orbital Involvement In Sinonasal Diseases.
Qazi ZU, Latif S, Awan SM
J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):687-693. PMID: 28586604
Sinonasal squamous cell carcinoma and the prognostic implications of its histologic variants: a population-based study.
Vazquez A, Khan MN, Blake DM, Patel TD, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2015 Jan;5(1):85-91. Epub 2014 Oct 2 doi: 10.1002/alr.21418. PMID: 25278180
NUT midline carcinomas of the sinonasal tract.
Bishop JA, Westra WH
Am J Surg Pathol 2012 Aug;36(8):1216-21. doi: 10.1097/PAS.0b013e318254ce54. PMID: 22534723Free PMC Article

Diagnosis

Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Orbital Involvement In Sinonasal Diseases.
Qazi ZU, Latif S, Awan SM
J Ayub Med Coll Abbottabad 2016 Oct-Dec;28(4):687-693. PMID: 28586604
Sinonasal squamous cell carcinoma and the prognostic implications of its histologic variants: a population-based study.
Vazquez A, Khan MN, Blake DM, Patel TD, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2015 Jan;5(1):85-91. Epub 2014 Oct 2 doi: 10.1002/alr.21418. PMID: 25278180
Diagnostically challenging lesions in head and neck pathology.
Thompson LD
Eur Arch Otorhinolaryngol 1997;254(8):357-66. doi: 10.1007/BF01642550. PMID: 9332890

Therapy

Perineural spread of malignant melanoma of the head and neck: clinical and imaging features.
Chang PC, Fischbein NJ, McCalmont TH, Kashani-Sabet M, Zettersten EM, Liu AY, Weissman JL
AJNR Am J Neuroradiol 2004 Jan;25(1):5-11. PMID: 14729519Free PMC Article
Diagnostically challenging lesions in head and neck pathology.
Thompson LD
Eur Arch Otorhinolaryngol 1997;254(8):357-66. doi: 10.1007/BF01642550. PMID: 9332890

Prognosis

Prognostic significance of head and neck spindle cell carcinoma.
Patel AM, Choudhry HS, Desai AD, Shah VP, Patel P, Eloy JA, Roden DF, Fang CH
Head Neck 2023 Mar;45(3):685-696. Epub 2022 Dec 30 doi: 10.1002/hed.27285. PMID: 36584171
Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.
Ackall FY, Issa K, Barak I, Teitelbaum J, Jang DW, Jung SH, Goldstein B, Carrau R, Abi Hachem R
Laryngoscope 2021 Apr;131(4):E1040-E1048. Epub 2020 Sep 22 doi: 10.1002/lary.29090. PMID: 32959912
Sinonasal Squamous Cell Carcinoma Presentation and Outcome: A National Perspective.
Al-Qurayshi Z, Smith R, Walsh JE
Ann Otol Rhinol Laryngol 2020 Nov;129(11):1049-1055. Epub 2020 May 31 doi: 10.1177/0003489420929048. PMID: 32476435
Clinical Utility of In Situ Hybridization Assays in Head and Neck Neoplasms.
Luk PP, Selinger CI, Cooper WA, Mahar A, Palme CE, O'Toole SA, Clark JR, Gupta R
Head Neck Pathol 2019 Sep;13(3):397-414. Epub 2018 Nov 22 doi: 10.1007/s12105-018-0988-1. PMID: 30467669Free PMC Article
Sinonasal squamous cell carcinoma and the prognostic implications of its histologic variants: a population-based study.
Vazquez A, Khan MN, Blake DM, Patel TD, Baredes S, Eloy JA
Int Forum Allergy Rhinol 2015 Jan;5(1):85-91. Epub 2014 Oct 2 doi: 10.1002/alr.21418. PMID: 25278180

Clinical prediction guides

Survival Outcomes in Sinonasal Poorly Differentiated Squamous Cell Carcinoma.
Ackall FY, Issa K, Barak I, Teitelbaum J, Jang DW, Jung SH, Goldstein B, Carrau R, Abi Hachem R
Laryngoscope 2021 Apr;131(4):E1040-E1048. Epub 2020 Sep 22 doi: 10.1002/lary.29090. PMID: 32959912
Metastatic SMARCB1 (INI-1)-Deficient Sinonasal Carcinoma Diagnosed by Endobronchial Ultrasound-Guided Fine-Needle Aspiration (EBUS-FNA): A Potential Diagnostic Pitfall and Review of the Literature.
McHugh KE, Policarpio-Nicolas MLC
Acta Cytol 2019;63(5):431-437. Epub 2019 May 27 doi: 10.1159/000500351. PMID: 31132763
NUT midline carcinomas of the sinonasal tract.
Bishop JA, Westra WH
Am J Surg Pathol 2012 Aug;36(8):1216-21. doi: 10.1097/PAS.0b013e318254ce54. PMID: 22534723Free PMC Article

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...