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Series GSE45425 Query DataSets for GSE45425
Status Public on May 27, 2013
Title Runx1 targets in early B-cell progenitors
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Expression profiling by array
Summary The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
Overall design Refer to individual Series
Citation(s) 23704093
Submission date Mar 22, 2013
Last update date May 15, 2019
Contact name Neele Margarete Kriebitzsch
Organization name Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology
Lab Molecular Pathology
Street address Martinistra├če 52
City Hamburg
ZIP/Postal code 20251
Country Germany
Platforms (3)
GPL7202 Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
GPL11202 Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version)
Samples (10)
GSM1103378 Runx1_ChIPseq
GSM1103379 IgG_ChIPseq
GSM1104066 proB-cell line_Runx1-ERt2_EtOH
This SuperSeries is composed of the following SubSeries:
GSE45377 Genome-wide mapping of Runx1-bound sites in early B-cell progenitors
GSE45424 Gene expression analysis to identify Runx1 target genes in B-cell progenitors
BioProject PRJNA193679

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45425_RAW.tar 71.6 Mb (http)(custom) TAR (of TXT)
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