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Status |
Public on May 27, 2013 |
Title |
Runx1 targets in early B-cell progenitors |
Organism |
Mus musculus |
Experiment type |
Genome binding/occupancy profiling by high throughput sequencing Expression profiling by array
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Summary |
The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
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Overall design |
Refer to individual Series
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Citation(s) |
23704093 |
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Submission date |
Mar 22, 2013 |
Last update date |
May 15, 2019 |
Contact name |
Neele Margarete Kriebitzsch |
E-mail(s) |
neele.kriebitzsch@hpi.uni-hamburg.de
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Organization name |
Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology
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Lab |
Molecular Pathology
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Street address |
Martinistraße 52
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City |
Hamburg |
ZIP/Postal code |
20251 |
Country |
Germany |
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Platforms (3) |
GPL7202 |
Agilent-014868 Whole Mouse Genome Microarray 4x44K G4122F (Probe Name version) |
GPL11002 |
Illumina Genome Analyzer IIx (Mus musculus) |
GPL11202 |
Agilent-026655 Whole Mouse Genome Microarray 4x44K v2 (Probe Name version) |
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Samples (10)
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This SuperSeries is composed of the following SubSeries: |
GSE45377 |
Genome-wide mapping of Runx1-bound sites in early B-cell progenitors |
GSE45424 |
Gene expression analysis to identify Runx1 target genes in B-cell progenitors |
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Relations |
BioProject |
PRJNA193679 |