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Series GSE45377 Query DataSets for GSE45377
Status Public on May 27, 2013
Title Genome-wide mapping of Runx1-bound sites in early B-cell progenitors
Organism Mus musculus
Experiment type Genome binding/occupancy profiling by high throughput sequencing
Summary The t(12;21) chromosomal translocation, targeting the gene encoding the RUNX1 transcription factor, is observed in 25% of pediatric acute lymphoblastic leukemia (ALL) and is an initiating event in the disease. To elucidate the mechanism by which RUNX1 disruption initiates leukemogenesis, we investigated its normal role in murine B-cell development. Gene expression analysis and genome-wide Runx1-occupancy studies support the hypothesis that Runx1 reinforces the transcription factor network in B-cell progenitors governing early B-cell survival and development .
 
Overall design ChIP-seq experiments were performed in the proB-cell line BMiFLT3(15-3), stably transduced with the transcription factor Runx1, to identify Runx1-bound sites in early B-cell progenitors.
 
Contributor(s) Niebuhr B, Kriebitzsch N, Alawi M, Stocking C
Citation(s) 23704093
Submission date Mar 21, 2013
Last update date May 15, 2019
Contact name Neele Margarete Kriebitzsch
E-mail(s) neele.kriebitzsch@hpi.uni-hamburg.de
Organization name Heinrich-Pette-Institute, Leibniz Institute for Experimental Virology
Lab Molecular Pathology
Street address Martinistra├če 52
City Hamburg
ZIP/Postal code 20251
Country Germany
 
Platforms (1)
GPL11002 Illumina Genome Analyzer IIx (Mus musculus)
Samples (2)
GSM1103378 Runx1_ChIPseq
GSM1103379 IgG_ChIPseq
This SubSeries is part of SuperSeries:
GSE45425 Runx1 targets in early B-cell progenitors
Relations
SRA SRP019917
BioProject PRJNA193697

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE45377_Runx_IgG_peaks.bed.gz 115.7 Kb (ftp)(http) BED
SRA Run SelectorHelp
Raw data are available in SRA
Processed data are available on Series record

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