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Select item 48951.

Analysis of brains deficient for SIRT1. SIRT1 is an NAD-dependent protein deacetylase that play a role in numerous metabolic processes in many tissues, including the brain. Results provide insight into the impact of SIRT1 on brain physiology.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE28790
8 Samples

Download data: CEL

DataSet

Accession:: GDS4895

ID:: 4895

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56772.

Mutant isocitrate dehydrogenase 1 effect on hepatoblasts grown on uncoated plates

Analysis of mutant IDH1 (R132C)-expressing hepatoblasts that were grown on uncoated plates to induce hepatocyte differentiation. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into the role of IDH1 in hepatocyte differentiation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE57002
4 Samples

Download data: CEL

DataSet

Accession:: GDS5677

ID:: 5677

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56763.

Mutant isocitrate dehydrogenase 1 and 2 effect on hepatoblasts grown on collagen-coated plates

Analysis of hepatoblasts expressing mutant IDH1 (R132C) and mutant IDH2 (R172K) grown on collagen-coated plates. IDH genes are frequently mutated in intrahepatic cholangiocarcinoma (IHCC). Results provide insight into molecular pathways by which IDH mutations lead to tumor formation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 5 genotype/variation sets

Platform:: GPL8321
Series:: GSE57002
10 Samples

Download data: CEL

DataSet

Accession:: GDS5676

ID:: 5676

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56674.

Protein tyrosine phosphatase receptor-δ and cyclin-dependent kinase inhibitor 2A deficiency effect on RCAS PDGFB/Nestin tv-A glioma model

Analysis of RCAS PDGFB/Nestin tv-A glioma cells from Ptprd knockout and Cdkn2a/p16Ink4a knockout mice. PTPRD is a tumor suppressor of glioma that is often co-deleted with tumor suppressor p16INK4A. Results provide insight into the cooperative effects of PTPRD and p16INK4A loss in gliomagenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 3 genotype/variation sets

Platform:: GPL8321
Series:: GSE55061
7 Samples

Download data: CEL

DataSet

Accession:: GDS5667

ID:: 5667

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56545.

Subcutaneous and visceral adipose tissues

Analysis of adipose tissue from two subcutaneous depots (inguinal and axillary) and two visceral depots (epididymal and mesenteric) from age-matched, C57Bl/6 males. SubQ and VISC represent two broad categories of obesity. Results provide insight into fat depot-specific molecular profiles.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 other, 2 tissue sets

Platform:: GPL8321
Series:: GSE53307
12 Samples

Download data: CEL

DataSet

Accession:: GDS5654

ID:: 5654

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 56376.

Platelet-derived growth factor inhibitor effect on lymphocytic cells expressing FIP1L1-PDGFRα or ETV6-PDGFRβ

Analysis of Ba/F3 cells expressing a constitutively active form of PDGFRα or PDGFRβ oncogene (Fip1L1-PDGFRα or TEL-PDGFRβ) and treated with imatinib (Glivec), a potent PDGFR inhibitor. Results provide insight into target genes of the PI3K/PKB/FOXO pathway downstream of growth factor stimulation.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent, 3 genotype/variation, 2 growth protocol sets

Platform:: GPL8321
Series:: GSE44810
6 Samples

Download data: CEL, CHP, DAT, XML

DataSet

Accession:: GDS5637

ID:: 5637

Select item 55037.

Small molecule GW8510 effect on pancreatic beta cell

Analysis of pancreatic beta cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5502, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL8321
Series:: GSE31102
6 Samples

Download data: CEL

DataSet

Accession:: GDS5503

ID:: 5503

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 55028.

Small molecule GW8510 effect on pancreatic alpha cell

Analysis of pancreatic alpha cells treated with GW8510, a CDK2 inhibitor. Insulin expression is largely restricted to pancreatic beta cells. These results, together with those of GDS5503, provide insight into potential mechanisms of insulin induction by non-beta pancreatic cell types.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL8321
Series:: GSE31102
6 Samples

Download data: CEL

DataSet

Accession:: GDS5502

ID:: 5502

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 55009.

Stem cell antigen-1 deficient mammary tumor

Analysis of mammary tumors from mutants lacking stem cell antigen-1 (Sca-1), a glycerophosphatidylinositol-anchored protein. Tumorigenesis induced by medroxyprogesterone and 7,12dimethylbenz(a)anthracene treatment. Results provide insight into the role of Sca-1 in mammary gland tumorigenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation, 2 tissue sets

Platform:: GPL8321
Series:: GSE31954
4 Samples

Download data: CEL

DataSet

Accession:: GDS5500

ID:: 5500

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 546410.

NFATc1 deficiency effect on osteoclast differentiation in vitro

Analysis of osteoclasts lacking the transcription factor NFATc1. Osteoclasts cultured in the presence of M-CSF and RANKL to induce differentiation. Results identify gene targets of NFATc1 in osteoclastogenesis.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE37219
4 Samples

Download data: CEL

DataSet

Accession:: GDS5464

ID:: 5464

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 534411.

Streptozotocin-induced type 1 diabetes model: brain hypothalamus

Analysis of hypothalamus from streptozotocin-induced diabetic males (a model of insulin-deficient, type 1 diabetes). The hypothalamus controls the endocrine system, appetite and energy balance. Results provide molecular insight into how diabetes affects hypothalamic function.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 3 disease state sets

Platform:: GPL8321
Series:: GSE62013
17 Samples

Download data: CEL

DataSet

Accession:: GDS5344

ID:: 5344

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 525612.

Caveolin-1 deficiency effect on dexamethasone treatment: embryonic day E14.5 cerebral cortex

Analysis of E14.5 cerebral cortex, Caveolin-1 (Cav-1) deficient, cultured neurospheres treated with glucocorticoid (GC) dexamethasone (100nM, 4h). Cav-1 involved in GC signaling in neural stem cells. Results provide insight into role of Cav-1 in GC treatment and impact fetal brain development.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 agent, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE49804
20 Samples

Download data: CEL

DataSet

Accession:: GDS5256

ID:: 5256

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 516413.

GATA-3 deficiency effect on regulatory T cell

Analysis of regulatory T (Treg) cells from mutants deficient for the transcription factor GATA-3. GATA-3 forms a complex with the transcription factor Fox3p, essential in the function of Treg cells. Results provide insight into the role of GATA-3 in the regulation of the Treg transcriptome.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE39864
6 Samples

Download data: CEL

DataSet

Accession:: GDS5164

ID:: 5164

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 511214.

Heart response to Trypanosoma cruzi infection

Analysis of hearts of C57BL/6 animals infected with the intracellular parasite Trypanosoma cruzi. T. cruzi causes Chagas disease which can lead to cardiomyopathy. Results provide insight into the molecular mechanisms underlying the innate immune response in the heart to T. cruzi infections.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 infection sets

Platform:: GPL8321
Series:: GSE41089
6 Samples

Download data: CEL, CHP

DataSet

Accession:: GDS5112

ID:: 5112

Select item 506515.

X-box binding protein 1 overexpression effect on adipocyte cell line

Analysis of F424a adipocytes overexpressing an active spliced form of X-box binding protein 1 (XBP1). XBP is a transcription factor involved in the unfolded protein response. Results provide insight into the function of XBP1 in adipocytes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 agent sets

Platform:: GPL8321
Series:: GSE46178
8 Samples

Download data: CEL

DataSet

Accession:: GDS5065

ID:: 5065

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 494516.

FG-3019/gemcitabine combined-treatment effect on KPC model of pancreatic ductal adenocarcinoma

Analysis of PDA tumors isolated from KPC (LSL-KrasG12D/+;LSL-Trp53R172H/+;Pdx-1-Cre) mice after combined treatment with FG-3019 (a mAb directed against CTGF) and chemotherapy drug gemcitabine. Results provide insight into the molecular basis of the enhanced anti-PDA activity of FG-3019/gemcitabine.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 protocol sets

Platform:: GPL8321
Series:: GSE46203
24 Samples

Download data: CEL

DataSet

Accession:: GDS4945

ID:: 4945

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 492817.

Acetaminophen effect on thioredoxin reductase 1-null liver

Analysis of liver from hepatocyte-specific, thioredoxin reductase 1 (TrxR1)-null mutants treated with the pro-toxin acetaminophen. The Trx system impacts bioenergetics and drug metabolism. Results provide insight into the role of the Trx system in detoxifying certain xenobiotic challenges.

Organism:: Mus musculus

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL8321
Series:: GSE37874
12 Samples

Download data: CEL

DataSet

Accession:: GDS4928

ID:: 4928

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 491918.

Models of rhabdomyosarcoma and undifferentiated pleomorphic sarcoma

Analysis of MyoD-derived sarcomas derived from MDKP (MyoDCE/+; LSL-KrasG12D/+;Trp53Fl/Fl) mice and histological variants (UPS, pleomorphic RMS, and embryonal RMS) from P7KP (Pax7CE/+;LSL-KrasG12D/+;Trp53Fl/Fl) mice. Results provide insight into molecular differences underlying the sarcoma subtypes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 4 disease state, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE46836
27 Samples

Download data: CEL

DataSet

Accession:: GDS4919

ID:: 4919

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 485619.

Transcription factor Yin Yang 1 deficiency effect on the skeletal muscle

Analysis of the soleus muscles of transcription factor Yin Yang 1 (YY1) deficient animals. Many nuclear genes encoding mitochondrial proteins contain binding sites for YY1 in their proximal promoters. Results provide insight into the role of YY1 in mitochondrial function.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 genotype/variation sets

Platform:: GPL8321
Series:: GSE39009
7 Samples

Download data: CEL

DataSet

Accession:: GDS4856

ID:: 4856

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 485120.

TRPV4 depletion effect on adipocyte cell line

Analysis of 3T3-F442A adipocytes depleted for transient receptor potential vanilloid 4 (TRPV4). TRPV4 is a cation channel. Results provide insight into the function of TRPV4 in adipocytes.

Organism:: Mus musculus

Type:: Expression profiling by array, count, 2 protocol sets

Platform:: GPL8321
Series:: GSE40280
4 Samples

Download data: CEL

DataSet

Accession:: GDS4851

ID:: 4851

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

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