Platelet-derived growth factor inhibitor effect on lymphocytic cells expressing FIP1L1-PDGFRα or ETV6-PDGFRβ
Summary:
Analysis of Ba/F3 cells expressing a constitutively active form of PDGFRα or PDGFRβ oncogene (Fip1L1-PDGFRα or TEL-PDGFRβ) and treated with imatinib (Glivec), a potent PDGFR inhibitor. Results provide insight into target genes of the PI3K/PKB/FOXO pathway downstream of growth factor stimulation.
Coomans de Brachène A, Bollaert E, Eijkelenboom A, de Rocca Serra A et al. The expression of the tumour suppressor HBP1 is down-regulated by growth factors via the PI3K/PKB/FOXO pathway. Biochem J 2014 May 15;460(1):25-34. PMID: 24762137
