Analysis of brains deficient for SIRT1. SIRT1 is an NAD-dependent protein deacetylase that play a role in numerous metabolic processes in many tissues, including the brain. Results provide insight into the impact of SIRT1 on brain physiology.
Libert S, Pointer K, Bell EL, Das A et al. SIRT1 activates MAO-A in the brain to mediate anxiety and exploratory drive. Cell 2011 Dec 23;147(7):1459-72. PMID: 22169038