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| Status |
Public on Jun 08, 2013 |
| Title |
Shifted Metabolic Bias in Livers of Mice Lacking Hepatocytic Thioredoxin Reductase-1 Protects Against Acetaminophen Toxicity |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by array
|
| Summary |
Genetic disruption of thioredoxin reductase 1 protects against acetaminophen (APAP) toxicity.
To determine the role of the thioredoxin system on xenobiotic metabolism we challeneged wildtype and txnrd1liver-null mice with acetaminophen.
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| Overall design |
Adult male wildtype and txnrd1 liver-null mice (C57BL6/J) were treated with either saline (PBS) or 100mg/kg APAP. Liver RNA was harvested eight hours after challenge and processed for microarray analysis.
Comparison of 2 treatment conditions in 2 genotypes, biological replicates in triplicate.
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| Contributor(s) |
Schmidt EE, Iverson SV |
| Citation(s) |
23743293 |
| |
| Submission date |
May 09, 2012 |
| Last update date |
May 04, 2018 |
| Contact name |
Ed Schmidt |
| E-mail(s) |
eschmidt@montana.edu
|
| Phone |
406 994-6375
|
| Organization name |
Montana State University
|
| Department |
M&I Dept
|
| Street address |
PO Box 173520
|
| City |
Bozeman |
| State/province |
MT |
| ZIP/Postal code |
59717 |
| Country |
USA |
| |
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| Platforms (1) |
| GPL8321 |
[Mouse430A_2] Affymetrix Mouse Genome 430A 2.0 Array |
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| Samples (12)
|
| GSM929282 |
liver cells from wildtype 8wk male mouse 8 challenged with vehicle (saline)_8 |
| GSM929283 |
liver cells from wildtype 8wk male mouse 8 challenged with vehicle (saline)_9 |
| GSM929284 |
liver cells from wildtype 8wk male mouse 8 challenged with vehicle (saline)_10 |
| GSM929285 |
liver cells from wildtype 8wk male mouse 8 challenged with acetaminophen (APAP)_12 |
| GSM929286 |
liver cells from wildtype 8wk male mouse 8 challenged with acetaminophen (APAP)_13 |
| GSM929287 |
liver cells from wildtype 8wk male mouse 8 challenged with acetaminophen (APAP)_14 |
| GSM929288 |
liver cells from txnrd1 liver-null 8wk male mouse 8 challenged with vehicle (saline)_4 |
| GSM929289 |
liver cells from txnrd1 liver-null 8wk male mouse 8 challenged with vehicle (saline)_5 |
| GSM929290 |
liver cells from txnrd1 liver-null 8wk male mouse 8 challenged with vehicle (saline)_16 |
| GSM929291 |
liver cells from txnrd1 liver-null 8wk male mouse 8 challenged with acetaminophen (APAP)_2 |
| GSM929292 |
liver cells from txnrd1 liver-null 8wk male mouse 8 challenged with acetaminophen (APAP)_3 |
| GSM929293 |
liver cells from txnrd1 liver-null 8wk male mouse 8 challenged with acetaminophen (APAP)_17 |
|
| Relations |
| BioProject |
PRJNA164703 |
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