Streptozotocin-induced type 1 diabetes model: brain hypothalamus
Summary:
Analysis of hypothalamus from streptozotocin-induced diabetic males (a model of insulin-deficient, type 1 diabetes). The hypothalamus controls the endocrine system, appetite and energy balance. Results provide molecular insight into how diabetes affects hypothalamic function.
Suzuki R, Lee K, Jing E, Biddinger SB et al. Diabetes and insulin in regulation of brain cholesterol metabolism. Cell Metab 2010 Dec 1;12(6):567-79. PMID: 21109190