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Hepatobiliary neoplasm

MedGen UID:
208891
•Concept ID:
C0854196
•
Neoplastic Process
Synonyms: Hepatic and Biliary Neoplasms; hepatic and biliary neoplasms; Hepatic and Biliary Tumors; hepatic and biliary tumors; hepatic and biliary tumours; Hepatic, Biliary, and Gallbladder Neoplasms; hepatic, biliary, and gallbladder neoplasms; Hepato-Biliary Neoplasm; hepato-biliary neoplasm; Hepato-Biliary Tumor; hepato-biliary tumor; hepato-biliary tumour; Hepatobiliary Neoplasm; hepatobiliary neoplasm; hepatobiliary system neoplasm; hepatobiliary system neoplasm (disease); hepatobiliary system tumor; hepatobiliary system tumour; Hepatobiliary Tumor; hepatobiliary tumor; Hepatobiliary Tumors; hepatobiliary tumors; hepatobiliary tumour; hepatobiliary tumours; Liver and Biliary Neoplasm; liver and biliary neoplasm; Liver and Biliary System Neoplasm; liver and biliary system neoplasm; neoplasm of hepatobiliary system; tumor of hepatobiliary system; tumour of hepatobiliary system
 
Monarch Initiative: MONDO:0002514

Definition

A benign or malignant neoplasm that affects the liver parenchyma, bile ducts, and gallbladder. Representative examples of benign neoplasms include hepatocellular adenoma, bile duct adenoma, and gallbladder lipoma. Representative examples of malignant neoplasms include hepatocellular carcinoma, intrahepatic and extrahepatic cholangiocarcinoma, and gallbladder carcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHepatobiliary neoplasm

Professional guidelines

PubMed

International evidence-based Kyoto guidelines for the management of intraductal papillary mucinous neoplasm of the pancreas.
Ohtsuka T, Fernandez-Del Castillo C, Furukawa T, Hijioka S, Jang JY, Lennon AM, Miyasaka Y, Ohno E, Salvia R, Wolfgang CL, Wood LD
Pancreatology 2024 Mar;24(2):255-270. Epub 2023 Dec 28 doi: 10.1016/j.pan.2023.12.009. PMID: 38182527
Pancreatic cancer: A review of clinical diagnosis, epidemiology, treatment and outcomes.
McGuigan A, Kelly P, Turkington RC, Jones C, Coleman HG, McCain RS
World J Gastroenterol 2018 Nov 21;24(43):4846-4861. doi: 10.3748/wjg.v24.i43.4846. PMID: 30487695Free PMC Article
Revisions of international consensus Fukuoka guidelines for the management of IPMN of the pancreas.
Tanaka M, Fernández-Del Castillo C, Kamisawa T, Jang JY, Levy P, Ohtsuka T, Salvia R, Shimizu Y, Tada M, Wolfgang CL
Pancreatology 2017 Sep-Oct;17(5):738-753. Epub 2017 Jul 13 doi: 10.1016/j.pan.2017.07.007. PMID: 28735806

Recent clinical studies

Etiology

Transgender Males on Gender-Affirming Hormone Therapy and Hepatobiliary Neoplasms: A Systematic Review.
Pothuri VS, Anzelmo M, Gallaher E, Ogunlana Y, Aliabadi-Wahle S, Tan B, Crippin JS, Hammill CW
Endocr Pract 2023 Oct;29(10):822-829. Epub 2023 Jun 5 doi: 10.1016/j.eprac.2023.05.011. PMID: 37286102
Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue.
Batts TL, Sasaki E, Miller M, Sparago J, Bauer RW, Paulsen D, Boudreaux B, Liu CC, Byrum SD, Johnston AN
PLoS One 2023;18(1):e0280928. Epub 2023 Jan 25 doi: 10.1371/journal.pone.0280928. PMID: 36696389Free PMC Article
IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism.
Yamada D, Ilyas SI, Razumilava N, Bronk SF, Davila JI, Champion MD, Borad MJ, Bezerra JA, Chen X, Gores GJ
Hepatology 2015 May;61(5):1627-42. Epub 2015 Mar 20 doi: 10.1002/hep.27687. PMID: 25580681Free PMC Article
CT angiography of the celiac trunk: anatomy, variants and pathologic findings.
Ozbülbül NI
Diagn Interv Radiol 2011 Jun;17(2):150-7. Epub 2010 Aug 6 doi: 10.4261/1305-3825.DIR.3283-10.1. PMID: 20690078
Mimics of cholangiocarcinoma: spectrum of disease.
Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN
Radiographics 2008 Jul-Aug;28(4):1115-29. doi: 10.1148/rg.284075148. PMID: 18635632

Diagnosis

Neoplastic signatures: Comparative proteomics of canine hepatobiliary neuroendocrine tumors to normal niche tissue.
Batts TL, Sasaki E, Miller M, Sparago J, Bauer RW, Paulsen D, Boudreaux B, Liu CC, Byrum SD, Johnston AN
PLoS One 2023;18(1):e0280928. Epub 2023 Jan 25 doi: 10.1371/journal.pone.0280928. PMID: 36696389Free PMC Article
Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma.
Moeini A, Sia D, Bardeesy N, Mazzaferro V, Llovet JM
Clin Cancer Res 2016 Jan 15;22(2):291-300. Epub 2015 Sep 24 doi: 10.1158/1078-0432.CCR-14-3296. PMID: 26405193
IL-33 facilitates oncogene-induced cholangiocarcinoma in mice by an interleukin-6-sensitive mechanism.
Yamada D, Ilyas SI, Razumilava N, Bronk SF, Davila JI, Champion MD, Borad MJ, Bezerra JA, Chen X, Gores GJ
Hepatology 2015 May;61(5):1627-42. Epub 2015 Mar 20 doi: 10.1002/hep.27687. PMID: 25580681Free PMC Article
CT angiography of the celiac trunk: anatomy, variants and pathologic findings.
Ozbülbül NI
Diagn Interv Radiol 2011 Jun;17(2):150-7. Epub 2010 Aug 6 doi: 10.4261/1305-3825.DIR.3283-10.1. PMID: 20690078
Mimics of cholangiocarcinoma: spectrum of disease.
Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN
Radiographics 2008 Jul-Aug;28(4):1115-29. doi: 10.1148/rg.284075148. PMID: 18635632

Therapy

Transgender Males on Gender-Affirming Hormone Therapy and Hepatobiliary Neoplasms: A Systematic Review.
Pothuri VS, Anzelmo M, Gallaher E, Ogunlana Y, Aliabadi-Wahle S, Tan B, Crippin JS, Hammill CW
Endocr Pract 2023 Oct;29(10):822-829. Epub 2023 Jun 5 doi: 10.1016/j.eprac.2023.05.011. PMID: 37286102
Systemic therapies for intrahepatic cholangiocarcinoma.
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497

Prognosis

Systemic therapies for intrahepatic cholangiocarcinoma.
Kelley RK, Bridgewater J, Gores GJ, Zhu AX
J Hepatol 2020 Feb;72(2):353-363. doi: 10.1016/j.jhep.2019.10.009. PMID: 31954497
Molecular Pathogenesis and Targeted Therapies for Intrahepatic Cholangiocarcinoma.
Moeini A, Sia D, Bardeesy N, Mazzaferro V, Llovet JM
Clin Cancer Res 2016 Jan 15;22(2):291-300. Epub 2015 Sep 24 doi: 10.1158/1078-0432.CCR-14-3296. PMID: 26405193
Mimics of cholangiocarcinoma: spectrum of disease.
Menias CO, Surabhi VR, Prasad SR, Wang HL, Narra VR, Chintapalli KN
Radiographics 2008 Jul-Aug;28(4):1115-29. doi: 10.1148/rg.284075148. PMID: 18635632

Recent systematic reviews

Transgender Males on Gender-Affirming Hormone Therapy and Hepatobiliary Neoplasms: A Systematic Review.
Pothuri VS, Anzelmo M, Gallaher E, Ogunlana Y, Aliabadi-Wahle S, Tan B, Crippin JS, Hammill CW
Endocr Pract 2023 Oct;29(10):822-829. Epub 2023 Jun 5 doi: 10.1016/j.eprac.2023.05.011. PMID: 37286102

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