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Gallbladder papillary neoplasm

MedGen UID:
234293
•Concept ID:
C1333754
•
Neoplastic Process
Synonyms: gall bladder papillary epithelial neoplasm; Gallbladder ICPN; Gallbladder Intracholecystic Papillary (Tubular) Neoplasm; Gallbladder Intracholecystic Papillary Neoplasm; Gallbladder Intracystic/Intaductal Papillary Neoplasm; gallbladder papillary neoplasm; gallbladder papillomatosis; Intracystic Papillary Neoplasm; intracystic papillary neoplasm
 
Monarch Initiative: MONDO:0002518

Definition

An intracholecystic papillary neoplasm that arises from the epithelium of the gallbladder. Intraepithelial neoplasia is present. [from NCI]

Professional guidelines

PubMed

Intraductal tubulopapillary neoplasms of the bile ducts: identity, clinicopathologic characteristics, and differential diagnosis of a distinct entity among intraductal tumors.
Pehlivanoglu B, Adsay V
Hum Pathol 2023 Feb;132:12-19. Epub 2022 Aug 5 doi: 10.1016/j.humpath.2022.07.019. PMID: 35934108
Management of Polypoid Gallbladder Lesions in Children: A Multicenter Study.
Ballouhey Q, Binet A, Varlet F, Baudry M, Dubois R, Héry G, Podevin G, Abbo O, Arnaud A, Barras M, Guerin F, Reinberg O, Piolat C, Fourcade L
Eur J Pediatr Surg 2018 Feb;28(1):6-11. Epub 2017 Jul 2 doi: 10.1055/s-0037-1604114. PMID: 28669133
Differential diagnosis of sclerosing cholangiocarcinomas of the common hepatic duct (Klatskin tumors).
Wetter LA, Ring EJ, Pellegrini CA, Way LW
Am J Surg 1991 Jan;161(1):57-62; discussion 62-3. doi: 10.1016/0002-9610(91)90361-g. PMID: 1846276

Recent clinical studies

Etiology

Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder: A Short Review of Literature.
Saei Hamedani F, Garcia-Buitrago M
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):57-61. doi: 10.1097/PAI.0000000000000711. PMID: 31815746
Intracholecystic Papillary Neoplasms Are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.
Akita M, Fujikura K, Ajiki T, Fukumoto T, Otani K, Hirose T, Tominaga M, Itoh T, Zen Y
Am J Surg Pathol 2019 Jun;43(6):783-791. doi: 10.1097/PAS.0000000000001237. PMID: 30807303
Uncommon Intraluminal Tumors of the Gallbladder and Biliary Tract: Spectrum of Imaging Appearances.
Chatterjee A, Lopes Vendrami C, Nikolaidis P, Mittal PK, Bandy AJ, Menias CO, Hammond NA, Yaghmai V, Yang GY, Miller FH
Radiographics 2019 Mar-Apr;39(2):388-412. Epub 2019 Feb 1 doi: 10.1148/rg.2019180164. PMID: 30707646
Intracholecystic papillary-tubular neoplasm of gallbladder: A 5-year retrospective pathological study.
Hazarika P, Sharma MK
Indian J Pathol Microbiol 2018 Oct-Dec;61(4):516-519. doi: 10.4103/IJPM.IJPM_489_17. PMID: 30303140

Diagnosis

The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Intracholecystic Papillary-Tubular Neoplasms (ICPN) of the Gallbladder: A Short Review of Literature.
Saei Hamedani F, Garcia-Buitrago M
Appl Immunohistochem Mol Morphol 2020 Jan;28(1):57-61. doi: 10.1097/PAI.0000000000000711. PMID: 31815746
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
Gallbladder cancer.
Dawes LG
Cancer Treat Res 2001;109:145-55. doi: 10.1007/978-1-4757-3371-6_8. PMID: 11775433

Therapy

Ultrasound-guided percutaneous microwave ablation of gallbladder polyps: A case report.
Zhao H, Chen Y, Zhang Z, Shang M, Cai Y, Ge J, Min X, Wu X, Zhao S, Chen B
Medicine (Baltimore) 2023 Dec 22;102(51):e36622. doi: 10.1097/MD.0000000000036622. PMID: 38134113Free PMC Article
Granulocyte Colony-Stimulating Factor-Producing Gallbladder Cancer.
Kanaya N, Aoki H, Yamasaki R, Morihiro T, Takeuchi H
Acta Med Okayama 2016 Oct;70(5):393-396. doi: 10.18926/AMO/54599. PMID: 27777433
Gallbladder cancers: associated conditions, histological types, prognosis, and prevention.
Cariati A, Piromalli E, Cetta F
Eur J Gastroenterol Hepatol 2014 May;26(5):562-9. doi: 10.1097/MEG.0000000000000074. PMID: 24614695
Comparison of multidetector CT and endoscopic ultrasonography in malignant pancreatic mass lesions.
Arabul M, Karakus F, Alper E, Kandemir A, Celik M, Karakus V, Yucel K, Unsal B
Hepatogastroenterology 2012 Jul-Aug;59(117):1599-603. doi: 10.5754/hge11608. PMID: 22155849
Carbon dioxide-enhanced virtual MDCT cholangiopancreatography.
Sugimoto M, Yasuda H, Koda K, Suzuki M, Yamazaki M, Tezuka T, Kosugi C, Higuchi R, Watayo Y, Yagawa Y, Uemura S, Tsuchiya H, Azuma T
J Hepatobiliary Pancreat Sci 2010 Sep;17(5):601-10. Epub 2009 Oct 6 doi: 10.1007/s00534-009-0201-8. PMID: 19806296

Prognosis

ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.
Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H
J Pathol 2023 Sep;261(1):28-42. Epub 2023 Jun 22 doi: 10.1002/path.6144. PMID: 37345534
The Clinical and Pathologic Features of Intracholecystic Papillary-Tubular Neoplasms of the Gallbladder.
Abdelal H, Chatterjee D
Surg Pathol Clin 2022 Sep;15(3):565-577. doi: 10.1016/j.path.2022.05.011. PMID: 36049837
Imaging Features of Premalignant Biliary Lesions and Predisposing Conditions with Pathologic Correlation.
Zulfiqar M, Chatterjee D, Yoneda N, Hoegger MJ, Ronot M, Hecht EM, Bastati N, Ba-Ssalamah A, Bashir MR, Fowler K
Radiographics 2022 Sep-Oct;42(5):1320-1337. Epub 2022 Aug 5 doi: 10.1148/rg.210194. PMID: 35930475
Intracholecystic papillary-tubular neoplasms (ICPN) of the gallbladder (neoplastic polyps, adenomas, and papillary neoplasms that are ≥1.0 cm): clinicopathologic and immunohistochemical analysis of 123 cases.
Adsay V, Jang KT, Roa JC, Dursun N, Ohike N, Bagci P, Basturk O, Bandyopadhyay S, Cheng JD, Sarmiento JM, Escalona OT, Goodman M, Kong SY, Terry P
Am J Surg Pathol 2012 Sep;36(9):1279-301. doi: 10.1097/PAS.0b013e318262787c. PMID: 22895264
Gallbladder cancer.
Dawes LG
Cancer Treat Res 2001;109:145-55. doi: 10.1007/978-1-4757-3371-6_8. PMID: 11775433

Clinical prediction guides

Enteroblastic cholangiocarcinoma: An uncommon, underrecognized subtype of bile duct cancer.
Chun J, Moore M, Kelly P, Kanzawa M, Itoh T, Hong SM, Zen Y
Hum Pathol 2024 Feb;144:46-52. Epub 2024 Jan 30 doi: 10.1016/j.humpath.2024.01.011. PMID: 38301963
ELF3 suppresses gallbladder cancer development through downregulation of the EREG/EGFR/mTOR complex 1 signalling pathway.
Nakamura T, Nishikawa Y, Shiokawa M, Takeda H, Yokode M, Matsumoto S, Muramoto Y, Ota S, Yoshida H, Okada H, Kuwada T, Marui S, Matsumori T, Maruno T, Uza N, Kodama Y, Hatano E, Seno H
J Pathol 2023 Sep;261(1):28-42. Epub 2023 Jun 22 doi: 10.1002/path.6144. PMID: 37345534
Lymph node metastatic status could predict the prognosis of intracholecystic papillary neoplasm of gallbladder.
Nakayama M, Naito Y, Sadashima E, Kinjo Y, Kawahara A, Hisaka T, Okabe Y, Akiba J, Yano H
Hum Pathol 2023 Jul;137:63-70. Epub 2023 Apr 29 doi: 10.1016/j.humpath.2023.04.013. PMID: 37127081
Intracholecystic Papillary Neoplasms Are Distinct From Papillary Gallbladder Cancers: A Clinicopathologic and Exome-sequencing Study.
Akita M, Fujikura K, Ajiki T, Fukumoto T, Otani K, Hirose T, Tominaga M, Itoh T, Zen Y
Am J Surg Pathol 2019 Jun;43(6):783-791. doi: 10.1097/PAS.0000000000001237. PMID: 30807303
The Relationship Between Intracholecystic Papillary-Tubular Neoplasms and Invasive Carcinoma of the Gallbladder.
Argon A, Barbet FY, Nart D
Int J Surg Pathol 2016 Sep;24(6):504-11. Epub 2016 Apr 27 doi: 10.1177/1066896916644781. PMID: 27122163

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