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Hemorrhage

MedGen UID:
5503
•Concept ID:
C0019080
•
Pathologic Function
Synonyms: Bleeding; Hemorrhages
SNOMED CT: Bleeding (131148009); Hemorrhage (131148009); Hemorrhage (50960005); Extravasation of blood (50960005); Blood loss (50960005); Bleeding (50960005)

Definition

The flow of blood from a ruptured blood vessel. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Hemorrhage

Professional guidelines

PubMed

Management of clinical chorioamnionitis: an evidence-based approach.
Conde-Agudelo A, Romero R, Jung EJ, Garcia Sánchez ÁJ
Am J Obstet Gynecol 2020 Dec;223(6):848-869. Epub 2020 Sep 29 doi: 10.1016/j.ajog.2020.09.044. PMID: 33007269Free PMC Article
Intracerebral hemorrhage: an update on diagnosis and treatment.
Hostettler IC, Seiffge DJ, Werring DJ
Expert Rev Neurother 2019 Jul;19(7):679-694. Epub 2019 Jun 12 doi: 10.1080/14737175.2019.1623671. PMID: 31188036
Practice Bulletin No. 183: Postpartum Hemorrhage.
Committee on Practice Bulletins-Obstetrics
Obstet Gynecol 2017 Oct;130(4):e168-e186. doi: 10.1097/AOG.0000000000002351. PMID: 28937571

Recent clinical studies

Etiology

2023 Guideline for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage: A Guideline From the American Heart Association/American Stroke Association.
Hoh BL, Ko NU, Amin-Hanjani S, Chou SH-Y, Cruz-Flores S, Dangayach NS, Derdeyn CP, Du R, Hänggi D, Hetts SW, Ifejika NL, Johnson R, Keigher KM, Leslie-Mazwi TM, Lucke-Wold B, Rabinstein AA, Robicsek SA, Stapleton CJ, Suarez JI, Tjoumakaris SI, Welch BG
Stroke 2023 Jul;54(7):e314-e370. Epub 2023 May 22 doi: 10.1161/STR.0000000000000436. PMID: 37212182
Spontaneous Intracerebral Hemorrhage.
Sheth KN
N Engl J Med 2022 Oct 27;387(17):1589-1596. doi: 10.1056/NEJMra2201449. PMID: 36300975
Obstetrical Hemorrhage.
Kroh S, Waters JH
Anesthesiol Clin 2021 Dec;39(4):597-611. doi: 10.1016/j.anclin.2021.08.009. PMID: 34776099
Surgery for spontaneous intracerebral hemorrhage.
de Oliveira Manoel AL
Crit Care 2020 Feb 7;24(1):45. doi: 10.1186/s13054-020-2749-2. PMID: 32033578Free PMC Article
Recent advances in spontaneous intracerebral hemorrhage.
Garg R, Biller J
F1000Res 2019;8 Epub 2019 Mar 18 doi: 10.12688/f1000research.16357.1. PMID: 30906532Free PMC Article

Diagnosis

Interventions of Postpartum Hemorrhage.
Post SE, Rood KM, Kiefer MK
Clin Obstet Gynecol 2023 Jun 1;66(2):367-383. Epub 2023 May 5 doi: 10.1097/GRF.0000000000000785. PMID: 37204172
Massive Hemorrhage Protocol: A Practical Approach to the Bleeding Trauma Patient.
Petrosoniak A, Pavenski K, da Luz LT, Callum J
Emerg Med Clin North Am 2023 Feb;41(1):51-69. doi: 10.1016/j.emc.2022.09.010. PMID: 36424044
Shock in Trauma.
Leech C, Turner J
Emerg Med Clin North Am 2023 Feb;41(1):1-17. doi: 10.1016/j.emc.2022.09.007. PMID: 36424034
Spinal Cord Hemorrhage.
Shaban A, Moritani T, Al Kasab S, Sheharyar A, Limaye KS, Adams HP Jr
J Stroke Cerebrovasc Dis 2018 Jun;27(6):1435-1446. Epub 2018 Mar 16 doi: 10.1016/j.jstrokecerebrovasdis.2018.02.014. PMID: 29555403
Intracerebral Hemorrhage.
Sansing LH
Semin Neurol 2016 Jun;36(3):223-4. Epub 2016 May 23 doi: 10.1055/s-0036-1583296. PMID: 27214696

Therapy

Treatment Options in Hemophilia.
Miesbach W, Schwäble J, Müller MM, Seifried E
Dtsch Arztebl Int 2019 Nov 22;116(47):791-798. doi: 10.3238/arztebl.2019.0791. PMID: 31847949Free PMC Article
Data Standardization and Quality Management.
Lapchak PA, Zhang JH
Transl Stroke Res 2018 Feb;9(1):4-8. Epub 2017 Mar 10 doi: 10.1007/s12975-017-0531-9. PMID: 28283966
Bridging Anticoagulation: Primum Non Nocere.
Rechenmacher SJ, Fang JC
J Am Coll Cardiol 2015 Sep 22;66(12):1392-403. doi: 10.1016/j.jacc.2015.08.002. PMID: 26383727
Amyloid-related imaging abnormalities in amyloid-modifying therapeutic trials: recommendations from the Alzheimer's Association Research Roundtable Workgroup.
Sperling RA, Jack CR Jr, Black SE, Frosch MP, Greenberg SM, Hyman BT, Scheltens P, Carrillo MC, Thies W, Bednar MM, Black RS, Brashear HR, Grundman M, Siemers ER, Feldman HH, Schindler RJ
Alzheimers Dement 2011 Jul;7(4):367-85. doi: 10.1016/j.jalz.2011.05.2351. PMID: 21784348Free PMC Article
Cerebral arterial spasm--a controlled trial of nimodipine in patients with subarachnoid hemorrhage.
Allen GS, Ahn HS, Preziosi TJ, Battye R, Boone SC, Boone SC, Chou SN, Kelly DL, Weir BK, Crabbe RA, Lavik PJ, Rosenbloom SB, Dorsey FC, Ingram CR, Mellits DE, Bertsch LA, Boisvert DP, Hundley MB, Johnson RK, Strom JA, Transou CR
N Engl J Med 1983 Mar 17;308(11):619-24. doi: 10.1056/NEJM198303173081103. PMID: 6338383

Prognosis

Epidemiology and definition of PPH worldwide.
Bláha J, Bartošová T
Best Pract Res Clin Anaesthesiol 2022 Dec;36(3-4):325-339. Epub 2022 Nov 13 doi: 10.1016/j.bpa.2022.11.001. PMID: 36513428
Spontaneous Intracerebral Hemorrhage.
Fallenius M, Skrifvars MB, Reinikainen M, Bendel S, Curtze S, Sibolt G, Martinez-Majander N, Raj R
Stroke 2019 Sep;50(9):2336-2343. Epub 2019 Jul 17 doi: 10.1161/STROKEAHA.118.024560. PMID: 31311464
Effect of Aspirin on Disability-free Survival in the Healthy Elderly.
McNeil JJ, Woods RL, Nelson MR, Reid CM, Kirpach B, Wolfe R, Storey E, Shah RC, Lockery JE, Tonkin AM, Newman AB, Williamson JD, Margolis KL, Ernst ME, Abhayaratna WP, Stocks N, Fitzgerald SM, Orchard SG, Trevaks RE, Beilin LJ, Donnan GA, Gibbs P, Johnston CI, Ryan J, Radziszewska B, Grimm R, Murray AM; ASPREE Investigator Group
N Engl J Med 2018 Oct 18;379(16):1499-1508. Epub 2018 Sep 16 doi: 10.1056/NEJMoa1800722. PMID: 30221596Free PMC Article
Spontaneous Intracerebral Hemorrhage.
Alerhand S, Lay C
Emerg Med Clin North Am 2017 Nov;35(4):825-845. doi: 10.1016/j.emc.2017.07.002. PMID: 28987431
Subarachnoid Hemorrhage: Updates in Diagnosis and Management.
Long B, Koyfman A, Runyon MS
Emerg Med Clin North Am 2017 Nov;35(4):803-824. Epub 2017 Aug 24 doi: 10.1016/j.emc.2017.07.001. PMID: 28987430

Clinical prediction guides

ABC score: a new risk score that accurately predicts mortality in acute upper and lower gastrointestinal bleeding: an international multicentre study.
Laursen SB, Oakland K, Laine L, Bieber V, Marmo R, Redondo-Cerezo E, Dalton HR, Ngu J, Schultz M, Soncini M, Gralnek I, Jairath V, Murray IA, Stanley AJ
Gut 2021 Apr;70(4):707-716. Epub 2020 Jul 28 doi: 10.1136/gutjnl-2019-320002. PMID: 32723845
Predicting risk of postpartum haemorrhage: a systematic review.
Neary C, Naheed S, McLernon DJ, Black M
BJOG 2021 Jan;128(1):46-53. Epub 2020 Aug 5 doi: 10.1111/1471-0528.16379. PMID: 32575159
Comparison of risk scoring systems for patients presenting with upper gastrointestinal bleeding: international multicentre prospective study.
Stanley AJ, Laine L, Dalton HR, Ngu JH, Schultz M, Abazi R, Zakko L, Thornton S, Wilkinson K, Khor CJ, Murray IA, Laursen SB; International Gastrointestinal Bleeding Consortium
BMJ 2017 Jan 4;356:i6432. doi: 10.1136/bmj.i6432. PMID: 28053181Free PMC Article
A risk score to predict need for treatment for upper-gastrointestinal haemorrhage.
Blatchford O, Murray WR, Blatchford M
Lancet 2000 Oct 14;356(9238):1318-21. doi: 10.1016/S0140-6736(00)02816-6. PMID: 11073021
Indices to measure gingival bleeding.
Newbrun E
J Periodontol 1996 Jun;67(6):555-61. doi: 10.1902/jop.1996.67.6.555. PMID: 8794964

Recent systematic reviews

Comment on the 2023 Guidelines for the Management of Patients With Aneurysmal Subarachnoid Hemorrhage.
Spears WE, Greer DM, Nguyen TN
Stroke 2023 Oct;54(10):2708-2712. Epub 2023 Aug 15 doi: 10.1161/STROKEAHA.123.043541. PMID: 37581267
Prenatal anemia and postpartum hemorrhage risk: A systematic review and meta-analysis.
Omotayo MO, Abioye AI, Kuyebi M, Eke AC
J Obstet Gynaecol Res 2021 Aug;47(8):2565-2576. Epub 2021 May 17 doi: 10.1111/jog.14834. PMID: 34002432Free PMC Article
Risk Factors for Atonic Postpartum Hemorrhage: A Systematic Review and Meta-analysis.
Ende HB, Lozada MJ, Chestnut DH, Osmundson SS, Walden RL, Shotwell MS, Bauchat JR
Obstet Gynecol 2021 Feb 1;137(2):305-323. doi: 10.1097/AOG.0000000000004228. PMID: 33417319Free PMC Article
Epidemiology, prevention and management of early postpartum hemorrhage - a systematic review.
Feduniw S, Warzecha D, Szymusik I, Wielgos M
Ginekol Pol 2020;91(1):38-44. doi: 10.5603/GP.2020.0009. PMID: 32039467
Interventions for treating post-extraction bleeding.
Kumbargere Nagraj S, Prashanti E, Aggarwal H, Lingappa A, Muthu MS, Kiran Kumar Krishanappa S, Hassan H
Cochrane Database Syst Rev 2018 Mar 4;3(3):CD011930. doi: 10.1002/14651858.CD011930.pub3. PMID: 29502332Free PMC Article

Supplemental Content

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