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Second trimester bleeding

MedGen UID:
747720
•Concept ID:
C2316827
•
Pathologic Function
Synonyms: Antepartum Hemorrhage, Second Trimester; Second Trimester Antepartum Hemorrhage
SNOMED CT: Second trimester bleeding (430881000)

Definition

Excessive blood loss within the second trimester but prior to onset of labor. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSecond trimester bleeding

Professional guidelines

PubMed

Diagnosis and treatment of uterine artery pseudoaneurysm: Case series and literature review.
Wu T, Lin B, Li K, Ye J, Wu R
Medicine (Baltimore) 2021 Dec 23;100(51):e28093. doi: 10.1097/MD.0000000000028093. PMID: 34941050Free PMC Article
The diagnosis and management of morbidly adherent placenta.
Belfort MA, Shamshirsaz AA, Fox KA
Semin Perinatol 2018 Feb;42(1):49-58. Epub 2017 Nov 28 doi: 10.1053/j.semperi.2017.11.009. PMID: 29195695
Fetal and neonatal alloimmune thrombocytopenia: evidence based antenatal and postnatal management strategies.
Winkelhorst D, Oepkes D, Lopriore E
Expert Rev Hematol 2017 Aug;10(8):729-737. Epub 2017 Jun 29 doi: 10.1080/17474086.2017.1346471. PMID: 28644735

Recent clinical studies

Etiology

Double-blind randomized trial of progesterone to prevent preterm birth in second-trimester bleeding.
Salim R, Hakim M, Zafran N, Nachum Z, Romano S, Garmi G
Acta Obstet Gynecol Scand 2019 Oct;98(10):1318-1325. Epub 2019 Jun 1 doi: 10.1111/aogs.13641. PMID: 31087325
Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding.
Mor A, Tal R, Haberman S, Kalgi B, Nasab SH, Minkoff H
Fertil Steril 2018 Jun;109(6):1060-1064. doi: 10.1016/j.fertnstert.2018.02.006. PMID: 29935643
Critical analysis of risk factors and outcome of placenta previa.
Rosenberg T, Pariente G, Sergienko R, Wiznitzer A, Sheiner E
Arch Gynecol Obstet 2011 Jul;284(1):47-51. Epub 2010 Jul 22 doi: 10.1007/s00404-010-1598-7. PMID: 20652281
Overview of common obstetric bleeding disorders.
Carter S
Nurse Pract 1999 Mar;24(3):50-1, 54, 57-8 passim. PMID: 10100241
Effects of first and second trimester vaginal bleeding on pregnancy outcome.
Karim SA, Bakhtawar I, Butta AT, Jalil M
J Pak Med Assoc 1998 Feb;48(2):40-2. PMID: 9610092

Diagnosis

Double-blind randomized trial of progesterone to prevent preterm birth in second-trimester bleeding.
Salim R, Hakim M, Zafran N, Nachum Z, Romano S, Garmi G
Acta Obstet Gynecol Scand 2019 Oct;98(10):1318-1325. Epub 2019 Jun 1 doi: 10.1111/aogs.13641. PMID: 31087325
Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding.
Mor A, Tal R, Haberman S, Kalgi B, Nasab SH, Minkoff H
Fertil Steril 2018 Jun;109(6):1060-1064. doi: 10.1016/j.fertnstert.2018.02.006. PMID: 29935643
Overview of common obstetric bleeding disorders.
Carter S
Nurse Pract 1999 Mar;24(3):50-1, 54, 57-8 passim. PMID: 10100241
Subchorionic hemorrhage: sonographic diagnosis and clinical significance.
Abu-Yousef MM, Bleicher JJ, Williamson RA, Weiner CP
AJR Am J Roentgenol 1987 Oct;149(4):737-40. doi: 10.2214/ajr.149.4.737. PMID: 3307354
The importance of antepartum cardiotocography.
Breuker KH, Kusche M, Müller U, Bolte A
J Perinat Med 1986;14(3):171-9. doi: 10.1515/jpme.1986.14.3.171. PMID: 3783388

Therapy

Double-blind randomized trial of progesterone to prevent preterm birth in second-trimester bleeding.
Salim R, Hakim M, Zafran N, Nachum Z, Romano S, Garmi G
Acta Obstet Gynecol Scand 2019 Oct;98(10):1318-1325. Epub 2019 Jun 1 doi: 10.1111/aogs.13641. PMID: 31087325
Same-day confirmation of intrauterine pregnancy failure in women with first- and early second-trimester bleeding.
Mor A, Tal R, Haberman S, Kalgi B, Nasab SH, Minkoff H
Fertil Steril 2018 Jun;109(6):1060-1064. doi: 10.1016/j.fertnstert.2018.02.006. PMID: 29935643
Peripartum cesarean hysterectomy: critical analysis of risk factors and trends over the years.
Orbach A, Levy A, Wiznitzer A, Mazor M, Holcberg G, Sheiner E
J Matern Fetal Neonatal Med 2011 Mar;24(3):480-4. Epub 2010 Jul 19 doi: 10.3109/14767058.2010.501128. PMID: 20636233
Zolpidem addiction in a pregnant woman with a history of second-trimester bleeding.
Askew JP
Pharmacotherapy 2007 Feb;27(2):306-8. doi: 10.1592/phco.27.2.306. PMID: 17253922
Pregnancy following uterine artery embolisation for symptomatic fibroids: a series of 26 completed pregnancies.
Carpenter TT, Walker WJ
BJOG 2005 Mar;112(3):321-5. doi: 10.1111/j.1471-0528.2004.00414.x. PMID: 15713147

Prognosis

Peripartum cesarean hysterectomy: critical analysis of risk factors and trends over the years.
Orbach A, Levy A, Wiznitzer A, Mazor M, Holcberg G, Sheiner E
J Matern Fetal Neonatal Med 2011 Mar;24(3):480-4. Epub 2010 Jul 19 doi: 10.3109/14767058.2010.501128. PMID: 20636233
Placenta previa: obstetric risk factors and pregnancy outcome.
Sheiner E, Shoham-Vardi I, Hallak M, Hershkowitz R, Katz M, Mazor M
J Matern Fetal Med 2001 Dec;10(6):414-9. doi: 10.1080/714052784. PMID: 11798453
Effects of abuse on maternal complications and birth weight in adult and adolescent women.
Curry MA, Perrin N, Wall E
Obstet Gynecol 1998 Oct;92(4 Pt 1):530-4. doi: 10.1016/s0029-7844(98)00258-0. PMID: 9764624
Effects of first and second trimester vaginal bleeding on pregnancy outcome.
Karim SA, Bakhtawar I, Butta AT, Jalil M
J Pak Med Assoc 1998 Feb;48(2):40-2. PMID: 9610092
Subchorionic hemorrhage: sonographic diagnosis and clinical significance.
Abu-Yousef MM, Bleicher JJ, Williamson RA, Weiner CP
AJR Am J Roentgenol 1987 Oct;149(4):737-40. doi: 10.2214/ajr.149.4.737. PMID: 3307354

Clinical prediction guides

Critical analysis of risk factors and outcome of placenta previa.
Rosenberg T, Pariente G, Sergienko R, Wiznitzer A, Sheiner E
Arch Gynecol Obstet 2011 Jul;284(1):47-51. Epub 2010 Jul 22 doi: 10.1007/s00404-010-1598-7. PMID: 20652281
Peripartum cesarean hysterectomy: critical analysis of risk factors and trends over the years.
Orbach A, Levy A, Wiznitzer A, Mazor M, Holcberg G, Sheiner E
J Matern Fetal Neonatal Med 2011 Mar;24(3):480-4. Epub 2010 Jul 19 doi: 10.3109/14767058.2010.501128. PMID: 20636233
Maternal prenatal pregnancy-related anxiety and spontaneous preterm birth in Baltimore, Maryland.
Orr ST, Reiter JP, Blazer DG, James SA
Psychosom Med 2007 Jul-Aug;69(6):566-70. Epub 2007 Jul 16 doi: 10.1097/PSY.0b013e3180cac25d. PMID: 17636150
Zolpidem addiction in a pregnant woman with a history of second-trimester bleeding.
Askew JP
Pharmacotherapy 2007 Feb;27(2):306-8. doi: 10.1592/phco.27.2.306. PMID: 17253922
The importance of antepartum cardiotocography.
Breuker KH, Kusche M, Müller U, Bolte A
J Perinat Med 1986;14(3):171-9. doi: 10.1515/jpme.1986.14.3.171. PMID: 3783388

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