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Vaginal bleeding

MedGen UID:
453354
•Concept ID:
C2979982
•
Pathologic Function
Synonyms: Bleeding, Vaginal; Bleedings, Vaginal; Vaginal Bleeding; Vaginal Bleedings
SNOMED CT: Observations of vaginal bleeding (289530006); Bleeding from vagina (289530006); Vaginal bleeding (289530006)

Definition

Bleeding originating from the vagina. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVVaginal bleeding

Professional guidelines

PubMed

Overview of ectopic pregnancy diagnosis, management, and innovation.
Mullany K, Minneci M, Monjazeb R, C Coiado O
Womens Health (Lond) 2023 Jan-Dec;19:17455057231160349. doi: 10.1177/17455057231160349. PMID: 36999281Free PMC Article
Endometrial polyps. An evidence-based diagnosis and management guide.
Vitale SG, Haimovich S, Laganà AS, Alonso L, Di Spiezio Sardo A, Carugno J; From the Global Community of Hysteroscopy Guidelines Committee
Eur J Obstet Gynecol Reprod Biol 2021 May;260:70-77. Epub 2021 Mar 13 doi: 10.1016/j.ejogrb.2021.03.017. PMID: 33756339
Ectopic Pregnancy: Diagnosis and Management.
Hendriks E, Rosenberg R, Prine L
Am Fam Physician 2020 May 15;101(10):599-606. PMID: 32412215

Recent clinical studies

Etiology

Postpartum Hemorrhage: Emergency Management for Uncontrolled Vaginal Bleeding.
Wilbeck J, Hoffman JW, Schorn MN
Adv Emerg Nurs J 2022 Jul-Sep 01;44(3):213-219. doi: 10.1097/TME.0000000000000421. PMID: 35900241
Investigation and management of abnormal peri-menopausal bleeding.
Turnbull H, Glover A, Morris EP, Duncan TJ, Nieto JJ, Burbos N
Menopause Int 2013 Dec;19(4):147-54. Epub 2013 Oct 16 doi: 10.1177/1754045313498587. PMID: 24132616
Postmenopausal bleeding-first steps in the workup.
Null DB, Weiland CM, Camlibel AR
J Fam Pract 2012 Oct;61(10):597-604. PMID: 23106061
First trimester complications.
Martonffy AI, Rindfleisch K, Lozeau AM, Potter B
Prim Care 2012 Mar;39(1):71-82. Epub 2011 Nov 30 doi: 10.1016/j.pop.2011.11.004. PMID: 22309582
Electricity and bones.
Br Med J 1980 Aug 16;281(6238):470-1. PMID: 6968615Free PMC Article

Diagnosis

Bleeding from Gynecologic Malignancies.
Hutchcraft ML, Miller RW
Obstet Gynecol Clin North Am 2022 Sep;49(3):607-622. doi: 10.1016/j.ogc.2022.02.022. PMID: 36122988
Third-Trimester Vaginal Bleeding.
Febres-Cordero D, Young BC
Neoreviews 2020 Aug;21(8):e580-e586. doi: 10.1542/neo.21-8-e580. PMID: 32737177
Clinical management of vaginal bleeding in postmenopausal women.
Carugno J
Climacteric 2020 Aug;23(4):343-349. Epub 2020 Apr 1 doi: 10.1080/13697137.2020.1739642. PMID: 32233689
Female Nonobstetric Genitourinary Emergencies.
Mahonski S, Hu KM
Emerg Med Clin North Am 2019 Nov;37(4):771-784. doi: 10.1016/j.emc.2019.07.012. PMID: 31563207
Vaginal Bleeding in Late Pregnancy.
Young JS, White LM
Emerg Med Clin North Am 2019 May;37(2):251-264. Epub 2019 Mar 8 doi: 10.1016/j.emc.2019.01.006. PMID: 30940370

Therapy

Oral dydrogesterone for prevention of miscarriage in threatened miscarriage: a randomized, double-blind, placebo-controlled trial.
Kuptarak A, Phupong V
J Matern Fetal Neonatal Med 2024 Dec;37(1):2333929. Epub 2024 Apr 3 doi: 10.1080/14767058.2024.2333929. PMID: 38570191
Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis.
Karimi A, Sayehmiri K, Vaismoradi M, Dianatinasab M, Daliri S
J Obstet Gynaecol 2024 Dec;44(1):2288224. Epub 2024 Feb 2 doi: 10.1080/01443615.2023.2288224. PMID: 38305047
Are Pelvic Exams Necessary Anymore?
Tucker P, Evans DD
Adv Emerg Nurs J 2019 Oct/Dec;41(4):282-289. doi: 10.1097/TME.0000000000000269. PMID: 31687992
Anastrozole: in early breast cancer.
Wellington K, Faulds DM
Drugs 2002;62(17):2483-90; discussion 2491-2. doi: 10.2165/00003495-200262170-00010. PMID: 12421108
Antiprogestins.
Crooij MS
Eur J Obstet Gynecol Reprod Biol 1988 Jun;28(2):129-32. doi: 10.1016/0028-2243(88)90091-3. PMID: 3042493

Prognosis

Adding Ovarian Suppression to Tamoxifen for Premenopausal Women With Hormone Receptor-Positive Breast Cancer After Chemotherapy: An 8-Year Follow-Up of the ASTRRA Trial.
Baek SY, Noh WC, Ahn SH, Kim HA, Ryu JM, Kim SI, Lee EG, Im SA, Jung Y, Park MH, Park KH, Kang SH, Jeong J, Park E, Kim SY, Lee MH, Kim LS, Lim W, Kim S, Kim HJ
J Clin Oncol 2023 Nov 1;41(31):4864-4871. Epub 2023 Aug 22 doi: 10.1200/JCO.23.00557. PMID: 37607321
Vaginal Bleeding Before 20 Weeks Gestation.
Banwarth-Kuhn B, McQuade M, Krashin JW
Obstet Gynecol Clin North Am 2023 Sep;50(3):473-492. Epub 2023 May 20 doi: 10.1016/j.ogc.2023.03.004. PMID: 37500211
Acquired Uterine Arteriovenous Malformation and Retained Placenta Increta.
Roach MK, Thomassee MS
Obstet Gynecol 2015 Sep;126(3):642-644. doi: 10.1097/AOG.0000000000000812. PMID: 25923029
Evan's syndrome revisited.
Dave P, Krishna K, Diwan AG
J Assoc Physicians India 2012 Apr;60:60-1. PMID: 23029746
Diagnosis and management of ectopic pregnancy.
Lozeau AM, Potter B
Am Fam Physician 2005 Nov 1;72(9):1707-14. PMID: 16300032

Clinical prediction guides

Perioperative risk factors of preterm delivery after fetoscopic laser photocoagulation for twin-twin transfusion syndrome.
Yamamoto R, Yamada T, Yamamoto R, Wagata M, Hayashi S, Ishii K
Prenat Diagn 2023 Mar;43(3):393-399. Epub 2023 Feb 7 doi: 10.1002/pd.6325. PMID: 36726286
Perceived stress and its predictors in women with threatened preterm labour: A cross-sectional study.
Najjarzadeh M, Abbasalizadeh S, Mohammad-Alizadeh-Charandabi S, Asghari-Jafarabadi M, Mirghafourvand M
Nurs Open 2022 Jan;9(1):210-221. Epub 2021 Sep 22 doi: 10.1002/nop2.1055. PMID: 34553513Free PMC Article
Diagnostic work-up in paediatric and adolescent patients with adnexal masses: an evidence-based approach.
Terzic M, Rapisarda AMC, Della Corte L, Manchanda R, Aimagambetova G, Norton M, Garzon S, Riemma G, King CR, Chiofalo B, Cianci A
J Obstet Gynaecol 2021 May;41(4):503-515. Epub 2020 Jul 14 doi: 10.1080/01443615.2020.1755625. PMID: 32662343
Uterine leiomyosarcoma: present management.
Giuntoli RL 2nd, Bristow RE
Curr Opin Oncol 2004 Jul;16(4):324-7. doi: 10.1097/01.cco.0000127721.55676.f6. PMID: 15187886
Chronic endometritis: morphologic and clinical observations.
Greenwood SM, Moran JJ
Obstet Gynecol 1981 Aug;58(2):176-84. PMID: 7254729

Recent systematic reviews

Vaginal bleeding in pregnancy and adverse clinical outcomes: a systematic review and meta-analysis.
Karimi A, Sayehmiri K, Vaismoradi M, Dianatinasab M, Daliri S
J Obstet Gynaecol 2024 Dec;44(1):2288224. Epub 2024 Feb 2 doi: 10.1080/01443615.2023.2288224. PMID: 38305047
Outcome of Cesarean scar pregnancy managed expectantly: systematic review and meta-analysis.
Calì G, Timor-Tritsch IE, Palacios-Jaraquemada J, Monteaugudo A, Buca D, Forlani F, Familiari A, Scambia G, Acharya G, D'Antonio F
Ultrasound Obstet Gynecol 2018 Feb;51(2):169-175. doi: 10.1002/uog.17568. PMID: 28661021
Short-term and long-term effects of tibolone in postmenopausal women.
Formoso G, Perrone E, Maltoni S, Balduzzi S, Wilkinson J, Basevi V, Marata AM, Magrini N, D'Amico R, Bassi C, Maestri E
Cochrane Database Syst Rev 2016 Oct 12;10(10):CD008536. doi: 10.1002/14651858.CD008536.pub3. PMID: 27733017Free PMC Article
Intrauterine device use among women with ovarian cancer: a systematic review.
Zapata LB, Whiteman MK, Marchbanks PA, Curtis KM
Contraception 2010 Jul;82(1):38-40. Epub 2010 Mar 29 doi: 10.1016/j.contraception.2010.02.013. PMID: 20682141
Use of combined oral contraceptives post abortion.
Gaffield ME, Kapp N, Ravi A
Contraception 2009 Oct;80(4):355-62. Epub 2009 Jun 4 doi: 10.1016/j.contraception.2009.04.005. PMID: 19751858

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