U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Subretinal hemorrhage

MedGen UID:
543137
•Concept ID:
C0271049
•
Pathologic Function
Synonyms: Subretinal haemorrhage; Subretinal heme
SNOMED CT: Subretinal hemorrhage (13937002)
 
HPO: HP:0025243

Definition

Accumulation of blood located beneath the neurosensory retina in the space between the neurosensory retina and the retinal pigment epithelium. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSubretinal hemorrhage

Professional guidelines

PubMed

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Management of subretinal hemorrhage.
Lauritzen DB, Weiter JJ
Int Ophthalmol Clin 2002 Summer;42(3):87-95. doi: 10.1097/00004397-200207000-00011. PMID: 12131586

Recent clinical studies

Etiology

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Bacillary layer detachment in acute nonpenetrating ocular trauma.
Venkatesh R, Agrawal S, Reddy NG, Pereira A, Yadav NK, Chhablani J
Can J Ophthalmol 2022 Oct;57(5):328-336. Epub 2021 Jun 27 doi: 10.1016/j.jcjo.2021.05.017. PMID: 34192520
Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Submacular hemorrhage removal.
Lim JI, Drews-Botsch C, Sternberg P Jr, Capone A Jr, Aaberg TM Sr
Ophthalmology 1995 Sep;102(9):1393-9. doi: 10.1016/s0161-6420(95)30858-5. PMID: 9097779

Diagnosis

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Acute intrapapillary and peripapillary subretinal hemorrhage.
Vigués-Jorba L, Grau Verger J, Martin Pujol R, Muñoz S
J Fr Ophtalmol 2021 Jun;44(6):926-928. Epub 2021 Feb 17 doi: 10.1016/j.jfo.2020.09.021. PMID: 33610394
Subretinal hemorrhage.
Yiu G, Mahmoud TH
Dev Ophthalmol 2014;54:213-22. Epub 2014 Aug 26 doi: 10.1159/000360469. PMID: 25196772
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391
Choroidal osteoma.
Bryan RN, Lewis RA, Miller SL
AJNR Am J Neuroradiol 1983 May-Jun;4(3):491-4. PMID: 6410779Free PMC Article

Therapy

Current Management of Subretinal Hemorrhage in Neovascular Age-Related Macular Degeneration.
Oncel D, Oncel D, Mishra K, Oncel M, Arevalo JF
Ophthalmologica 2023;246(5-6):295-305. Epub 2023 Oct 7 doi: 10.1159/000534440. PMID: 37806303
Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Submacular hemorrhage removal.
Lim JI, Drews-Botsch C, Sternberg P Jr, Capone A Jr, Aaberg TM Sr
Ophthalmology 1995 Sep;102(9):1393-9. doi: 10.1016/s0161-6420(95)30858-5. PMID: 9097779
Subretinal hemorrhage.
Lim JI
Int Ophthalmol Clin 1995 Fall;35(4):95-104. PMID: 8847196
Retinal arterial macroaneurysms.
Rabb MF, Gagliano DA, Teske MP
Surv Ophthalmol 1988 Sep-Oct;33(2):73-96. doi: 10.1016/0039-6257(88)90160-9. PMID: 3055391

Prognosis

A systematic review of the cell death mechanisms in retinal pigment epithelium cells and photoreceptors after subretinal hemorrhage - Implications for treatment options.
Chhatwal S, Antony H, Lamei S, Kovács-Öller T, Klettner AK, Zille M
Biomed Pharmacother 2023 Nov;167:115572. Epub 2023 Sep 22 doi: 10.1016/j.biopha.2023.115572. PMID: 37742603
Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Pathophysiology and management of subretinal hemorrhage.
Hochman MA, Seery CM, Zarbin MA
Surv Ophthalmol 1997 Nov-Dec;42(3):195-213. doi: 10.1016/s0039-6257(97)00089-1. PMID: 9406367
Submacular hemorrhage removal.
Lim JI, Drews-Botsch C, Sternberg P Jr, Capone A Jr, Aaberg TM Sr
Ophthalmology 1995 Sep;102(9):1393-9. doi: 10.1016/s0161-6420(95)30858-5. PMID: 9097779
Subretinal hemorrhage.
Lim JI
Int Ophthalmol Clin 1995 Fall;35(4):95-104. PMID: 8847196

Clinical prediction guides

Chinese Guideline on the Management of Polypoidal Choroidal Vasculopathy (2022).
Chen YX, Zhang YQ, Chen CZ, Dai H, Li SY, Ma X, Sun XD, Tang SB, Wang YS, Wei WB, Wen F, Xu GZ, Yu WH, Zhang MX, Zhao MW, Zhang Y, Qi F, Xu X, Li XX
Chin Med Sci J 2023 Jun 30;38(2):77-93. doi: 10.24920/004213. PMID: 37263796
Bacillary layer detachment in acute nonpenetrating ocular trauma.
Venkatesh R, Agrawal S, Reddy NG, Pereira A, Yadav NK, Chhablani J
Can J Ophthalmol 2022 Oct;57(5):328-336. Epub 2021 Jun 27 doi: 10.1016/j.jcjo.2021.05.017. PMID: 34192520
Characteristics of pachychoroid neovasculopathy.
Tagawa M, Ooto S, Yamashiro K, Tamura H, Oishi A, Miyata M, Hata M, Yoshikawa M, Yoshimura N, Tsujikawa A
Sci Rep 2020 Oct 1;10(1):16248. doi: 10.1038/s41598-020-73303-w. PMID: 33004959Free PMC Article
Demographic profile, clinical features, and outcome of peripapillary subretinal hemorrhage: an observational study.
Zou M, Zhang Y, Huang X, Gao S, Zhang J
BMC Ophthalmol 2020 Apr 19;20(1):156. doi: 10.1186/s12886-020-01426-9. PMID: 32306917Free PMC Article
To laser or not?
Govindhari V, Chhablani J
Indian J Ophthalmol 2018 Mar;66(3):463-466. doi: 10.4103/ijo.IJO_837_17. PMID: 29480271Free PMC Article

Recent systematic reviews

A systematic review of the cell death mechanisms in retinal pigment epithelium cells and photoreceptors after subretinal hemorrhage - Implications for treatment options.
Chhatwal S, Antony H, Lamei S, Kovács-Öller T, Klettner AK, Zille M
Biomed Pharmacother 2023 Nov;167:115572. Epub 2023 Sep 22 doi: 10.1016/j.biopha.2023.115572. PMID: 37742603
Pars plana vitrectomy versus scleral buckle: A comprehensive meta-analysis of 15,947 eyes.
Dhoot AS, Popovic MM, Nichani PAH, Eshtiaghi A, Mihalache A, Sayal AP, Yu H, Wykoff CC, Kertes PJ, Muni RH
Surv Ophthalmol 2022 Jul-Aug;67(4):932-949. Epub 2021 Dec 9 doi: 10.1016/j.survophthal.2021.12.005. PMID: 34896191
Summary of prognostic factors for choroidal neovascularization due to pathological myopia treated by intravitreal bevacizumab injection.
Wang J, Kang Z
Graefes Arch Clin Exp Ophthalmol 2012 Dec;250(12):1717-23. Epub 2012 Sep 25 doi: 10.1007/s00417-012-2159-5. PMID: 23007232

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...