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Rectal Undifferentiated Carcinoma

MedGen UID:
234451
Concept ID:
C1336864
Neoplastic Process
Synonyms: Anaplastic Carcinoma of Rectum; Anaplastic Carcinoma of the Rectum; Carcinoma Simplex of the Rectum.; Rectal Anaplastic Carcinoma; Undifferentiated Carcinoma of Rectum; Undifferentiated Carcinoma of the Rectum; Undifferentiated Rectal Carcinoma

Definition

An invasive malignant epithelial tumor that arises from the rectum. There is no morphologic, immunophenotypic, or molecular biological evidence of glandular or squamous differentiation. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal Undifferentiated Carcinoma

Professional guidelines

PubMed

Gonzalez RS
Surg Pathol Clin 2020 Sep;13(3):377-397. doi: 10.1016/j.path.2020.04.002. PMID: 32773190
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR; Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2018 Jul;61(7):755-774. doi: 10.1097/DCR.0000000000001114. PMID: 29878949
Goddard AF, James MW, McIntyre AS, Scott BB; British Society of Gastroenterology
Gut 2011 Oct;60(10):1309-16. Epub 2011 May 11 doi: 10.1136/gut.2010.228874. PMID: 21561874

Recent clinical studies

Etiology

Xia F, Wang Y, Wang H, Shen L, Xiang Z, Zhao Y, Zhang H, Wan J, Zhang H, Wang Y, Wu R, Wang J, Yang W, Zhou M, Zhou S, Chen Y, Zhang Z, Wu X, Xuan Y, Wang R, Sun Y, Tong T, Zhang X, Wang L, Huang D, Sheng W, Yan H, Yang X, Shen Y, Xu Y, Zhao R, Mo M, Cai G, Cai S, Xu Y, Zhang Z
J Clin Oncol 2024 Oct;42(28):3308-3318. Epub 2024 Jul 1 doi: 10.1200/JCO.23.02261. PMID: 38950321
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Cercek A, Roxburgh CSD, Strombom P, Smith JJ, Temple LKF, Nash GM, Guillem JG, Paty PB, Yaeger R, Stadler ZK, Seier K, Gonen M, Segal NH, Reidy DL, Varghese A, Shia J, Vakiani E, Wu AJ, Crane CH, Gollub MJ, Garcia-Aguilar J, Saltz LB, Weiser MR
JAMA Oncol 2018 Jun 14;4(6):e180071. doi: 10.1001/jamaoncol.2018.0071. PMID: 29566109Free PMC Article
Chiu MS, Verma V, Bennion NR, Bhirud AR, Li J, Charlton ME, Are C, Lin C
Cancer Med 2016 Dec;5(12):3394-3402. Epub 2016 Oct 26 doi: 10.1002/cam4.927. PMID: 27781400Free PMC Article
Ngan SY, Burmeister B, Fisher RJ, Solomon M, Goldstein D, Joseph D, Ackland SP, Schache D, McClure B, McLachlan SA, McKendrick J, Leong T, Hartopeanu C, Zalcberg J, Mackay J
J Clin Oncol 2012 Nov 1;30(31):3827-33. Epub 2012 Sep 24 doi: 10.1200/JCO.2012.42.9597. PMID: 23008301

Diagnosis

Congedo A, Mallardi D, Danti G, De Muzio F, Granata V, Miele V
Tomography 2023 Sep 4;9(5):1694-1710. doi: 10.3390/tomography9050135. PMID: 37736988Free PMC Article
Yamamoto T, Kotze PG, Spinelli A, Panaccione R
Expert Rev Gastroenterol Hepatol 2018 Sep;12(9):917-925. Epub 2018 Jul 24 doi: 10.1080/17474124.2018.1500175. PMID: 29999429
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR; Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2018 Jul;61(7):755-774. doi: 10.1097/DCR.0000000000001114. PMID: 29878949
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403
Garrett K, Kalady MF
Surg Clin North Am 2010 Feb;90(1):147-61, Table of Contents. doi: 10.1016/j.suc.2009.09.008. PMID: 20109639

Therapy

Lin ZY, Zhang P, Chi P, Xiao Y, Xu XM, Zhang AM, Qiu XF, Wu JX, Yuan Y, Wang ZN, Qu XJ, Li X, Nie X, Yang M, Cai KL, Zhang WK, Huang Y, Sun Z, Hou ZG, Ma C, Cheng FZ, Tao KX, Zhang T
Ann Oncol 2024 Oct;35(10):882-891. Epub 2024 Jul 2 doi: 10.1016/j.annonc.2024.06.015. PMID: 38964714
Boustani J, Huguet F, Vendrely V
Cancer Radiother 2023 Dec;27(8):768-777. Epub 2023 Oct 26 doi: 10.1016/j.canrad.2023.08.001. PMID: 38415359
Stewart DB, Gaertner WB, Glasgow SC, Herzig DO, Feingold D, Steele SR; Prepared on Behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dis Colon Rectum 2018 Jul;61(7):755-774. doi: 10.1097/DCR.0000000000001114. PMID: 29878949
Garcia-Aguilar J, Chow OS, Smith DD, Marcet JE, Cataldo PA, Varma MG, Kumar AS, Oommen S, Coutsoftides T, Hunt SR, Stamos MJ, Ternent CA, Herzig DO, Fichera A, Polite BN, Dietz DW, Patil S, Avila K; Timing of Rectal Cancer Response to Chemoradiation Consortium
Lancet Oncol 2015 Aug;16(8):957-66. Epub 2015 Jul 14 doi: 10.1016/S1470-2045(15)00004-2. PMID: 26187751Free PMC Article
Ngan SY, Burmeister B, Fisher RJ, Solomon M, Goldstein D, Joseph D, Ackland SP, Schache D, McClure B, McLachlan SA, McKendrick J, Leong T, Hartopeanu C, Zalcberg J, Mackay J
J Clin Oncol 2012 Nov 1;30(31):3827-33. Epub 2012 Sep 24 doi: 10.1200/JCO.2012.42.9597. PMID: 23008301

Prognosis

Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Erlandsson J, Holm T, Pettersson D, Berglund Å, Cedermark B, Radu C, Johansson H, Machado M, Hjern F, Hallböök O, Syk I, Glimelius B, Martling A
Lancet Oncol 2017 Mar;18(3):336-346. Epub 2017 Feb 10 doi: 10.1016/S1470-2045(17)30086-4. PMID: 28190762
Messick CA, Rodriguez-Bigas MA
Surg Oncol Clin N Am 2017 Jan;26(1):33-43. doi: 10.1016/j.soc.2016.07.005. PMID: 27889035
Inra JA, Syngal S
Dig Dis Sci 2015 Mar;60(3):722-33. Epub 2014 Dec 6 doi: 10.1007/s10620-014-3464-0. PMID: 25480403
Ngan SY, Burmeister B, Fisher RJ, Solomon M, Goldstein D, Joseph D, Ackland SP, Schache D, McClure B, McLachlan SA, McKendrick J, Leong T, Hartopeanu C, Zalcberg J, Mackay J
J Clin Oncol 2012 Nov 1;30(31):3827-33. Epub 2012 Sep 24 doi: 10.1200/JCO.2012.42.9597. PMID: 23008301

Clinical prediction guides

Williams H, Omer DM, Thompson HM, Lin ST, Verheij FS, Miranda J, Yuval JB, Buckley J, Marco MR, Qin LX, Dombroski DA, Kedar R, Oto A, Korngold E, Veniero JC, Gandhi S, Krishnaraj A, Jagtiani M, Ohanian K, Vu D, Hope TA, Lee S, Wasnik AP, Madhuripan N, Gollub MJ, Garcia-Aguilar J; OPRA Consortium
Radiology 2024 Sep;312(3):e232748. doi: 10.1148/radiol.232748. PMID: 39225603Free PMC Article
Erstad DJ, Dasari A, Taggart MW, Kaur H, Konishi T, Bednarski BK, Chang GJ
Ann Surg Oncol 2022 Apr;29(4):2539-2548. Epub 2021 Nov 17 doi: 10.1245/s10434-021-11016-8. PMID: 34787737
Kommalapati A, Tella SH, Yadav S, Goyal G, Hallemeier C, Durgin L, Jin Z, Mahipal A
Eur J Surg Oncol 2020 Jun;46(6):1111-1117. Epub 2020 Mar 4 doi: 10.1016/j.ejso.2020.02.039. PMID: 32201124
Pai RK, Pai RK
Mod Pathol 2018 Jan;31(1):4-23. Epub 2017 Aug 4 doi: 10.1038/modpathol.2017.87. PMID: 28776577
Gaertner WB, Kwaan MR, Madoff RD, Melton GB
World J Gastroenterol 2015 Jul 7;21(25):7659-71. doi: 10.3748/wjg.v21.i25.7659. PMID: 26167068Free PMC Article

Recent systematic reviews

Di Y, Ding L, Gao L, Huang H
BMC Cancer 2023 Aug 23;23(1):782. doi: 10.1186/s12885-023-11218-1. PMID: 37612616Free PMC Article
Yuan S, Sun J, Lu Y, Xu F, Li D, Jiang F, Wan Z, Li X, Qin LQ, Larsson SC
BMC Med 2022 Nov 23;20(1):455. doi: 10.1186/s12916-022-02658-w. PMID: 36424608Free PMC Article
Falz R, Bischoff C, Thieme R, Lässing J, Mehdorn M, Stelzner S, Busse M, Gockel I
J Cancer Res Clin Oncol 2022 Sep;148(9):2187-2213. Epub 2022 Jun 13 doi: 10.1007/s00432-022-04088-w. PMID: 35695931Free PMC Article
Farvid MS, Sidahmed E, Spence ND, Mante Angua K, Rosner BA, Barnett JB
Eur J Epidemiol 2021 Sep;36(9):937-951. Epub 2021 Aug 29 doi: 10.1007/s10654-021-00741-9. PMID: 34455534
McDermott FD, Heeney A, Courtney D, Mohan H, Winter D
Surg Endosc 2014 Jul;28(7):2020-6. Epub 2014 Mar 1 doi: 10.1007/s00464-014-3430-0. PMID: 24584484

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