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Rectal villous adenoma

MedGen UID:
152675
•Concept ID:
C0730199
•
Neoplastic Process
Synonyms: Rectal Villous Adenoma; rectal villous adenoma; rectum villous adenoma; Villous adenoma of rectum; Villous Adenoma of Rectum; villous adenoma of rectum; Villous Adenoma of the Rectum; villous adenoma of the rectum
SNOMED CT: Villous adenoma of rectum (312823001)
 
Monarch Initiative: MONDO:0006396

Definition

A neoplasm that arises from the glandular epithelium of the rectal mucosa. It is characterized by a villous architectural pattern. The neoplastic glandular cells have dysplastic features. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRectal villous adenoma

Professional guidelines

PubMed

Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer.
Zheng X, Hur J, Nguyen LH, Liu J, Song M, Wu K, Smith-Warner SA, Ogino S, Willett WC, Chan AT, Giovannucci E, Cao Y
J Natl Cancer Inst 2021 May 4;113(5):543-552. doi: 10.1093/jnci/djaa164. PMID: 33136160Free PMC Article
Screening/early detection model for colorectal cancer. Why screen?
Lieberman D
Cancer 1994 Oct 1;74(7 Suppl):2023-7. doi: 10.1002/1097-0142(19941001)74:7+<2023::aid-cncr2820741706>3.0.co;2-o. PMID: 8087765
Endoscopic laser treatment for rectosigmoid villous adenoma: factors affecting the results.
Brunetaud JM, Maunoury V, Cochelard D, Boniface B, Cortot A, Paris JC
Gastroenterology 1989 Aug;97(2):272-7. doi: 10.1016/0016-5085(89)90061-9. PMID: 2744351

Recent clinical studies

Etiology

Reliability in villous tumors staging between preoperative MRI and histopathological examination.
Vogrig C, Leclerc J, Haghnejad V, Orry X, Remen T, Germain A, Laurent V
Abdom Radiol (NY) 2020 Oct;45(10):3046-3056. doi: 10.1007/s00261-020-02450-5. PMID: 32123949
Treatment strategies and outcomes for rectal villous adenoma from a single-center experience.
Cho SD, Herzig DO, Douthit MA, Deveney KE
Arch Surg 2008 Sep;143(9):866-70; discussion 871-2. doi: 10.1001/archsurg.143.9.866. PMID: 18794424
The use of posterior trans-sphincteric approach in surgery of the rectum: a Chinese 16-year experience.
Qiu HZ, Lin GL, Xiao Y, Wu B
World J Surg 2008 Aug;32(8):1776-82. doi: 10.1007/s00268-008-9630-9. PMID: 18560934
Treatment of early rectal tumours by transanal endoscopic microsurgery in Hong Kong: prospective study.
Meng WC, Lau PY, Yip AW
Hong Kong Med J 2004 Aug;10(4):239-43. PMID: 15299168
Laparoscopic colorectal surgery--are we being honest with our patients?
Wexner SD, Cohen SM, Ulrich A, Reissman P
Dis Colon Rectum 1995 Jul;38(7):723-7. doi: 10.1007/BF02048029. PMID: 7607032

Diagnosis

Is magnetic resonance imaging useful for the management of patients with rectal villous adenoma? A study of 45 consecutive patients treated by transanal endoscopic microsurgery.
Raynaud L, Mege D, Zappa M, Guedj N, Vilgrain V, Panis Y
Int J Colorectal Dis 2018 Dec;33(12):1695-1701. Epub 2018 Aug 22 doi: 10.1007/s00384-018-3148-x. PMID: 30136172
McKittrick-Wheelock syndrome: a rare etiology of acute renal failure associated to well-differentiated adenocarcinoma (G1) arising within a villous adenoma.
Tuţă LA, Boşoteanu M, Deacu M, Dumitru E
Rom J Morphol Embryol 2011;52(3 Suppl):1153-6. PMID: 22119841
Appendiceal carcinoma masquerading as a rectal villous adenoma.
Keating JP, Mouat C, Strettell MD
Gastrointest Endosc 2001 Jan;53(1):124-5. doi: 10.1067/mge.2001.111562. PMID: 11154510
Laparoscopic colorectal surgery--are we being honest with our patients?
Wexner SD, Cohen SM, Ulrich A, Reissman P
Dis Colon Rectum 1995 Jul;38(7):723-7. doi: 10.1007/BF02048029. PMID: 7607032
Rectal villous adenoma producing hypokalemia.
Schrock LG, Polk HC Jr
Am Surg 1974 Jan;40(1):54-9. PMID: 4808623

Prognosis

McKittrick-Wheelock syndrome: a rare etiology of acute renal failure associated to well-differentiated adenocarcinoma (G1) arising within a villous adenoma.
Tuţă LA, Boşoteanu M, Deacu M, Dumitru E
Rom J Morphol Embryol 2011;52(3 Suppl):1153-6. PMID: 22119841
The McKittrick-Wheelock syndrome: a case of acute renal failure due to neoplastic cholera.
Winstanley V, Little MA, Wadsworth C, Cohen P, Martin NM
Ren Fail 2008;30(4):469-73. doi: 10.1080/08860220801964277. PMID: 18569924
Treatment of early rectal tumours by transanal endoscopic microsurgery in Hong Kong: prospective study.
Meng WC, Lau PY, Yip AW
Hong Kong Med J 2004 Aug;10(4):239-43. PMID: 15299168
Pneumomediastinum following transanal excision of a rectal tumour.
Farmer KC, Tjandra JJ, Hockenberry S, Fazio VW
Aust N Z J Surg 1993 Jul;63(7):568-71. doi: 10.1111/j.1445-2197.1993.tb00456.x. PMID: 8317987

Clinical prediction guides

Reliability in villous tumors staging between preoperative MRI and histopathological examination.
Vogrig C, Leclerc J, Haghnejad V, Orry X, Remen T, Germain A, Laurent V
Abdom Radiol (NY) 2020 Oct;45(10):3046-3056. doi: 10.1007/s00261-020-02450-5. PMID: 32123949
The McKittrick-Wheelock syndrome: a case of acute renal failure due to neoplastic cholera.
Winstanley V, Little MA, Wadsworth C, Cohen P, Martin NM
Ren Fail 2008;30(4):469-73. doi: 10.1080/08860220801964277. PMID: 18569924
Pneumomediastinum following transanal excision of a rectal tumour.
Farmer KC, Tjandra JJ, Hockenberry S, Fazio VW
Aust N Z J Surg 1993 Jul;63(7):568-71. doi: 10.1111/j.1445-2197.1993.tb00456.x. PMID: 8317987
Genetic events in sporadic colorectal adenomas: K-ras and p53 heterozygous mutations are not sufficient for malignant progression.
De Benedetti L, Varesco L, Pellegata NS, Losi L, Gismondi V, Casarino L, Sciallero S, Bonelli L, Biticchi R, Bafico A
Anticancer Res 1993 May-Jun;13(3):667-70. PMID: 8317895

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