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Testicular Mixed Embryonal Carcinoma and Teratoma with Seminoma

MedGen UID:
234420
•Concept ID:
C1336717
•
Neoplastic Process
Synonyms: Mixed Embryonal Carcinoma and Teratoma with Seminoma of Testis; Mixed Embryonal Carcinoma and Teratoma with Seminoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a mixture of embryonal carcinoma, a teratomatous component, and a seminomatous component. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Embryonal Carcinoma and Teratoma with Seminoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
D2-40 immunohistochemistry in the differential diagnosis of seminoma and embryonal carcinoma: a comparative immunohistochemical study with KIT (CD117) and CD30.
Lau SK, Weiss LM, Chu PG
Mod Pathol 2007 Mar;20(3):320-5. Epub 2007 Feb 2 doi: 10.1038/modpathol.3800749. PMID: 17277761
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Intratumoral heterogeneity and chemoresistance in nonseminomatous germ cell tumor of the testis.
Bilen MA, Hess KR, Campbell MT, Wang J, Broaddus RR, Karam JA, Ward JF, Wood CG, Choi SL, Rao P, Zhang M, Naing A, General R, Cauley DH, Lin SH, Logothetis CJ, Pisters LL, Tu SM
Oncotarget 2016 Dec 27;7(52):86280-86289. doi: 10.18632/oncotarget.13380. PMID: 27861143Free PMC Article
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Intratumoral heterogeneity and chemoresistance in nonseminomatous germ cell tumor of the testis.
Bilen MA, Hess KR, Campbell MT, Wang J, Broaddus RR, Karam JA, Ward JF, Wood CG, Choi SL, Rao P, Zhang M, Naing A, General R, Cauley DH, Lin SH, Logothetis CJ, Pisters LL, Tu SM
Oncotarget 2016 Dec 27;7(52):86280-86289. doi: 10.18632/oncotarget.13380. PMID: 27861143Free PMC Article
Testicular embryonal carcinoma: a morphologic study of 180 cases highlighting unusual and unemphasized aspects.
Kao CS, Ulbright TM, Young RH, Idrees MT
Am J Surg Pathol 2014 May;38(5):689-97. doi: 10.1097/PAS.0000000000000171. PMID: 24503753
Testicular tumors--some new and a few perennial problems.
Young RH
Arch Pathol Lab Med 2008 Apr;132(4):548-64. doi: 10.5858/2008-132-548-TTNAAF. PMID: 18384207
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Therapy

Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Pagliaro LC
J Clin Oncol 2017 Apr 1;35(10):1036-1040. Epub 2016 Dec 19 doi: 10.1200/JCO.2016.70.6523. PMID: 27992270
The management of inferior vena cava obstruction complicating metastatic germ cell tumors.
Hassan B, Tung K, Weeks R, Mead GM
Cancer 1999 Feb 15;85(4):912-8. PMID: 10091770
Potential therapeutic and diagnostic applications of the growth of testicular cancer in soft agar.
Foster BJ, Javadpour N, Ozols RF
Int J Cell Cloning 1983 Apr;1(1):2-14. doi: 10.1002/stem.5530010103. PMID: 6201566
Testicular cancer in cryptorchids.
Batata MA, Chu FC, Hilaris BS, Whitmore WF, Golbey RB
Cancer 1982 Mar 1;49(5):1023-30. doi: 10.1002/1097-0142(19820301)49:5<1023::aid-cncr2820490528>3.0.co;2-m. PMID: 6120755
Testicular tumors of germ cell origin.
Kaplan JH, Kudish HG, Sacks SA
Postgrad Med 1981 Dec;70(6):125-7, 130-1. doi: 10.1080/00325481.1981.11715938. PMID: 6796949

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Age-incidence patterns of seminoma and nonseminoma among males and females in Germany and the United States, 2008-2016.
Stang A, Trocchi P, Kajüter H, Trabert B, Oosterhuis JW, McGlynn KA
Andrology 2023 Jan;11(1):65-72. Epub 2022 Sep 12 doi: 10.1111/andr.13282. PMID: 36059277
Primary Cystic Trophoblastic Tumor of the Testis: A Study of 14 Cases.
Gondim DD, Ulbright TM, Cheng L, Idrees MT
Am J Surg Pathol 2017 Jun;41(6):788-794. doi: 10.1097/PAS.0000000000000830. PMID: 28296679
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653
Testicular cancer in cryptorchids.
Batata MA, Chu FC, Hilaris BS, Whitmore WF, Golbey RB
Cancer 1982 Mar 1;49(5):1023-30. doi: 10.1002/1097-0142(19820301)49:5<1023::aid-cncr2820490528>3.0.co;2-m. PMID: 6120755

Clinical prediction guides

Differential expression of preferentially expressed antigen in melanoma (PRAME) in testicular germ cell tumors - A comparative study with SOX17.
Zhou Y, Rothrock A, Murugan P, Li F, Bu L
Exp Mol Pathol 2022 Jun;126:104761. Epub 2022 Apr 4 doi: 10.1016/j.yexmp.2022.104761. PMID: 35390309
The diagnostic impact of testicular biopsies for intratubular germ cell neoplasia in cryptorchid boys and the subsequent risk of testicular cancer in men with prepubertal surgery for syndromic or non-syndromic cryptorchidism.
Osterballe L, Clasen-Linde E, Cortes D, Engholm G, Hertzum-Larsen R, Reinhardt S, Thorup J
J Pediatr Surg 2017 Apr;52(4):587-592. Epub 2016 Aug 27 doi: 10.1016/j.jpedsurg.2016.08.006. PMID: 27614808
Primary testicular carcinoid.
Hodzic J, Golka K, Schulze H
Med Sci Monit 2004 Aug;10(8):CS46-8. Epub 2004 Jul 23 PMID: 15278003
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908
Testicular cancer in cryptorchids.
Batata MA, Chu FC, Hilaris BS, Whitmore WF, Golbey RB
Cancer 1982 Mar 1;49(5):1023-30. doi: 10.1002/1097-0142(19820301)49:5<1023::aid-cncr2820490528>3.0.co;2-m. PMID: 6120755

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