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Testicular Mixed Choriocarcinoma and Teratoma

MedGen UID:
277811
•Concept ID:
C1336714
•
Neoplastic Process
Synonyms: Mixed Choriocarcinoma and Teratoma of Testis; Mixed Choriocarcinoma and Teratoma of the Testis

Definition

A malignant mixed germ cell tumor arising from the testis. It is characterized by the presence of a teratomatous component and malignant syncytiotrophoblastic cells. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVTesticular Mixed Choriocarcinoma and Teratoma

Professional guidelines

PubMed

Role of HNF1β in the differential diagnosis of yolk sac tumor from other germ cell tumors.
Rougemont AL, Tille JC
Hum Pathol 2018 Nov;81:26-36. Epub 2018 May 16 doi: 10.1016/j.humpath.2018.04.025. PMID: 29753846
Germ cell tumors of the gonads: a selective review emphasizing problems in differential diagnosis, newly appreciated, and controversial issues.
Ulbright TM
Mod Pathol 2005 Feb;18 Suppl 2:S61-79. doi: 10.1038/modpathol.3800310. PMID: 15761467
The treatment of cranial germ cell tumours.
Brandes AA, Pasetto LM, Monfardini S
Cancer Treat Rev 2000 Aug;26(4):233-42. doi: 10.1053/ctrv.2000.0169. PMID: 10913379

Recent clinical studies

Etiology

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Intratubular germ cell neoplasia of the testis: a brief review.
Al-Hussain T, Bakshi N, Akhtar M
Adv Anat Pathol 2015 May;22(3):202-12. doi: 10.1097/PAP.0000000000000066. PMID: 25844678
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908
Germ cell neoplasms of the testis.
Ulbright TM
Am J Surg Pathol 1993 Nov;17(11):1075-91. doi: 10.1097/00000478-199311000-00001. PMID: 8214253

Diagnosis

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Primary Cystic Trophoblastic Tumor of the Testis: A Study of 14 Cases.
Gondim DD, Ulbright TM, Cheng L, Idrees MT
Am J Surg Pathol 2017 Jun;41(6):788-794. doi: 10.1097/PAS.0000000000000830. PMID: 28296679
Pathology of germ cell tumors of the testis.
Sesterhenn IA, Davis CJ Jr
Cancer Control 2004 Nov-Dec;11(6):374-87. doi: 10.1177/107327480401100605. PMID: 15625525
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Therapy

Role of High-Dose Chemotherapy With Autologous Stem-Cell Rescue in Men With Previously Treated Germ Cell Tumors.
Pagliaro LC
J Clin Oncol 2017 Apr 1;35(10):1036-1040. Epub 2016 Dec 19 doi: 10.1200/JCO.2016.70.6523. PMID: 27992270
Sequential excision of residual thoracic and retroperitoneal masses after chemotherapy for stage III germ cell tumors.
Tiffany P, Morse MJ, Bosl G, Vaughan ED Jr, Sogani PC, Herr HW, Whitmore WF Jr
Cancer 1986 Mar 1;57(5):978-83. doi: 10.1002/1097-0142(19860301)57:5<978::aid-cncr2820570517>3.0.co;2-9. PMID: 3002596
Characteristics and chemotherapeutic sensitivity of a human testicular cancer grown in artificially immunosuppressed mice.
Lapis P, Kopper L, Bodrogi I, Sugár J, Lapis K, Eckhardt S
Oncology 1985;42(2):112-8. doi: 10.1159/000226012. PMID: 2581199
Potential therapeutic and diagnostic applications of the growth of testicular cancer in soft agar.
Foster BJ, Javadpour N, Ozols RF
Int J Cell Cloning 1983 Apr;1(1):2-14. doi: 10.1002/stem.5530010103. PMID: 6201566

Prognosis

Clinical Features and Survival Outcomes in Children and Adolescents With Malignant Mediastinal Germ Cell Tumors Based on Surveillance, Epidemiology, and End Results Database Analysis.
Wu P, Yang Y, Yu Z, Zhao L, Feng S
J Surg Res 2023 Aug;288:362-371. Epub 2023 Apr 14 doi: 10.1016/j.jss.2023.03.018. PMID: 37062232
Primary Cystic Trophoblastic Tumor of the Testis: A Study of 14 Cases.
Gondim DD, Ulbright TM, Cheng L, Idrees MT
Am J Surg Pathol 2017 Jun;41(6):788-794. doi: 10.1097/PAS.0000000000000830. PMID: 28296679
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908
Germ-cell tumors of the mediastinum.
Weidner N
Semin Diagn Pathol 1999 Feb;16(1):42-50. PMID: 10355653

Clinical prediction guides

Diagnostically misleading aberrant terminal deoxynucleotidyl transferase expression in germ cell tumors.
Pęksa R, Kunc M, Bieńkowski M, Popęda M, Biernat W
Pol J Pathol 2022;73(2):159-165. doi: 10.5114/pjp.2022.120098. PMID: 36345953
Differential expression of preferentially expressed antigen in melanoma (PRAME) in testicular germ cell tumors - A comparative study with SOX17.
Zhou Y, Rothrock A, Murugan P, Li F, Bu L
Exp Mol Pathol 2022 Jun;126:104761. Epub 2022 Apr 4 doi: 10.1016/j.yexmp.2022.104761. PMID: 35390309
ZBTB16: a novel sensitive and specific biomarker for yolk sac tumor.
Xiao GQ, Li F, Unger PD, Katerji H, Yang Q, McMahon L, Burstein DE
Mod Pathol 2016 Jun;29(6):591-8. Epub 2016 Feb 26 doi: 10.1038/modpathol.2016.46. PMID: 26916077
An overview of testicular germ cell tumors.
Bahrami A, Ro JY, Ayala AG
Arch Pathol Lab Med 2007 Aug;131(8):1267-80. doi: 10.5858/2007-131-1267-AOOTGC. PMID: 17683189
From the archives of the AFIP: tumors and tumorlike lesions of the testis: radiologic-pathologic correlation.
Woodward PJ, Sohaey R, O'Donoghue MJ, Green DE
Radiographics 2002 Jan-Feb;22(1):189-216. doi: 10.1148/radiographics.22.1.g02ja14189. PMID: 11796908

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