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Intratubular Seminoma

MedGen UID:
233471
•Concept ID:
C1336097
•
Neoplastic Process
Synonyms: Stage 0 Seminoma; Stage 0 Seminoma of Testis; Stage 0 Seminoma of the Testis; Stage 0 Testicular Seminoma; Stage 0 Testicular Seminoma AJCC v6, v7, and v8

Definition

Intratubular germ cell neoplasia characterized by the complete filling of the seminiferous tubules by seminoma cells. [from NCI]

Professional guidelines

PubMed

Testicular Germ Cell Tumors: Classification, Pathologic Features, Imaging Findings, and Management.
Katabathina VS, Vargas-Zapata D, Monge RA, Nazarullah A, Ganeshan D, Tammisetti V, Prasad SR
Radiographics 2021 Oct;41(6):1698-1716. doi: 10.1148/rg.2021210024. PMID: 34597218
Difficult differential diagnoses in testicular pathology.
Ye H, Ulbright TM
Arch Pathol Lab Med 2012 Apr;136(4):435-46. doi: 10.5858/arpa.2011-0475-RA. PMID: 22458906
The use of immunohistochemistry in the differential diagnosis of tumors of the testis and paratestis.
Emerson RE, Ulbright TM
Semin Diagn Pathol 2005 Feb;22(1):33-50. doi: 10.1053/j.semdp.2005.11.003. PMID: 16512598

Recent clinical studies

Etiology

Microinvasive germ cell tumor of the testis.
von Eyben FE, Jacobsen GK, Skotheim RI
Virchows Arch 2005 Sep;447(3):610-25. Epub 2005 Jun 21 doi: 10.1007/s00428-005-1257-8. PMID: 15968545
Macrophages lysing seminoma cells in patients with carcinoma-in-situ (CIS) of the testis.
Schütte B, Holstein AF, Schirren C
Andrologia 1988 Jul-Aug;20(4):295-303. PMID: 3195722
Intratubular malignant germ cells in testicular biopsies: clinical course and identification by staining for placental alkaline phosphatase.
Burke AP, Mostofi FK
Mod Pathol 1988 Nov;1(6):475-9. PMID: 2851788

Diagnosis

Germ cell neoplasms of the testis: Update for 2022.
Iczkowski KA
Semin Diagn Pathol 2023 Jan;40(1):2-21. Epub 2022 Jul 7 doi: 10.1053/j.semdp.2022.07.001. PMID: 35840444
Intratubular Teratoma: A Rare Form of Testicular Germ Cell Neoplasia.
Genco IS, Ratzon F, Glickman L, Santagada E, Unger P
Int J Surg Pathol 2019 Aug;27(5):556-560. Epub 2019 Mar 24 doi: 10.1177/1066896919836491. PMID: 30907201
Viral-type orchitis: a potential mimic of testicular neoplasia.
Braaten KM, Young RH, Ferry JA
Am J Surg Pathol 2009 Oct;33(10):1477-84. doi: 10.1097/PAS.0b013e3181ac36eb. PMID: 19623033
Morphology of testicular parenchyma adjacent to germ cell tumours. An interim report.
Oosterhuis JW, Kersemaekers AM, Jacobsen GK, Timmer A, Steyerberg EW, Molier M, Van Weeren PC, Stoop H, Looijenga LH
APMIS 2003 Jan;111(1):32-40; discussion 41-2. doi: 10.1034/j.1600-0463.2003.11101061.x. PMID: 12752231
Intratubular malignant germ cells in testicular biopsies: clinical course and identification by staining for placental alkaline phosphatase.
Burke AP, Mostofi FK
Mod Pathol 1988 Nov;1(6):475-9. PMID: 2851788

Prognosis

Intratubular malignant germ cells in testicular biopsies: clinical course and identification by staining for placental alkaline phosphatase.
Burke AP, Mostofi FK
Mod Pathol 1988 Nov;1(6):475-9. PMID: 2851788

Clinical prediction guides

Association of intratubular seminoma and intratubular embryonal carcinoma with invasive testicular germ cell tumors.
Lau SK, Weiss LM, Chu PG
Am J Surg Pathol 2007 Jul;31(7):1045-9. doi: 10.1097/PAS.0b013e31802b8712. PMID: 17592271
Morphology of testicular parenchyma adjacent to germ cell tumours. An interim report.
Oosterhuis JW, Kersemaekers AM, Jacobsen GK, Timmer A, Steyerberg EW, Molier M, Van Weeren PC, Stoop H, Looijenga LH
APMIS 2003 Jan;111(1):32-40; discussion 41-2. doi: 10.1034/j.1600-0463.2003.11101061.x. PMID: 12752231
Oncostatin M in the normal human testis and several testicular disorders.
De Miguel MP, Regadera J, Martinez-Garcia F, Nistal M, Paniagua R
J Clin Endocrinol Metab 1999 Feb;84(2):768-74. doi: 10.1210/jcem.84.2.5480. PMID: 10022451
Macrophages lysing seminoma cells in patients with carcinoma-in-situ (CIS) of the testis.
Schütte B, Holstein AF, Schirren C
Andrologia 1988 Jul-Aug;20(4):295-303. PMID: 3195722
On the histology of human seminoma: development of the solid tumor from intratubular seminoma cells.
Schulze C, Holstein AF
Cancer 1977 Mar;39(3):1090-100. doi: 10.1002/1097-0142(197703)39:3<1090::aid-cncr2820390313>3.0.co;2-4. PMID: 912648

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