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Benign Squamous Cell Neoplasm

MedGen UID:: 141634
•Concept ID:: C0474800
•: Neoplastic Process

Synonyms:	Benign Epidermoid Cell Neoplasm; Benign Epidermoid Cell Tumor; Benign squamous cell tumor; Benign Squamous Cell Tumor
SNOMED CT:	Benign squamous cell tumor (252994001)

Definition

A non-metastasizing neoplasm composed of squamous cells. The neoplastic cells do not display malignant features. [from NCI]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVBenign Squamous Cell Neoplasm

Pathological process
- Disease
  - Neoplasm
    - Neoplasm by Special Category
      - Benign neoplasm
        Benign epithelial neoplasm
        Benign Squamous Cell Neoplasm
        Craniopharyngioma
        Adamantinous craniopharyngioma
        Recurrent Adamantinomatous Craniopharyngioma
        Adult Craniopharyngioma
        Childhood Craniopharyngioma
        Papillary craniopharyngioma
        Recurrent Craniopharyngioma
        Unresectable Craniopharyngioma
        Plantar wart
        Squamous Papilloma
        Anal Canal Squamous Papilloma
        Bladder squamous papilloma
        Cervix squamous papilloma
        Conjunctival Squamous Papilloma
        Esophageal squamous papilloma
        Eyelid Squamous Papilloma
        Inverted Squamous Papilloma
        Larynx squamous papilloma
        Lung Squamous Papilloma
        Nasal vestibule squamous papilloma
        Nasopharyngeal Squamous Papilloma
        Oropharyngeal squamous papilloma
        Squamous cell skin papilloma
        Vaginal squamous papilloma
        Vestibular papilloma
        Vestibular micropapillomatosis
        Verrucae
        Disseminated cutaneous warts
        Epidermodysplasia verruciformis
        Genital warts
        Anal Condyloma Acuminatum
        Buschke Lowenstein tumor
        Cervical Condyloma Acuminatum
        Condyloma acuminata of vagina
        Condyloma acuminata of vulva
        Condyloma Acuminatum with Dysplasia
        Urethral Condyloma Acuminatum
        Oral Verruca Vulgaris
        Verruca plana

Professional guidelines

PubMed

International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors.

Kuan EC, Wang EW, Adappa ND, Beswick DM, London NR Jr, Su SY, Wang MB, Abuzeid WM, Alexiev B, Alt JA, Antognoni P, Alonso-Basanta M, Batra PS, Bhayani M, Bell D, Bernal-Sprekelsen M, Betz CS, Blay JY, Bleier BS, Bonilla-Velez J, Callejas C, Carrau RL, Casiano RR, Castelnuovo P, Chandra RK, Chatzinakis V, Chen SB, Chiu AG, Choby G, Chowdhury NI, Citardi MJ, Cohen MA, Dagan R, Dalfino G, Dallan I, Dassi CS, de Almeida J, Dei Tos AP, DelGaudio JM, Ebert CS, El-Sayed IH, Eloy JA, Evans JJ, Fang CH, Farrell NF, Ferrari M, Fischbein N, Folbe A, Fokkens WJ, Fox MG, Lund VJ, Gallia GL, Gardner PA, Geltzeiler M, Georgalas C, Getz AE, Govindaraj S, Gray ST, Grayson JW, Gross BA, Grube JG, Guo R, Ha PK, Halderman AA, Hanna EY, Harvey RJ, Hernandez SC, Holtzman AL, Hopkins C, Huang Z, Huang Z, Humphreys IM, Hwang PH, Iloreta AM, Ishii M, Ivan ME, Jafari A, Kennedy DW, Khan M, Kimple AJ, Kingdom TT, Knisely A, Kuo YJ, Lal D, Lamarre ED, Lan MY, Le H, Lechner M, Lee NY, Lee JK, Lee VH, Levine CG, Lin JC, Lin DT, Lobo BC, Locke T, Luong AU, Magliocca KR, Markovic SN, Matnjani G, McKean EL, Meço C, Mendenhall WM, Michel L, Na'ara S, Nicolai P, Nuss DW, Nyquist GG, Oakley GM, Omura K, Orlandi RR, Otori N, Papagiannopoulos P, Patel ZM, Pfister DG, Phan J, Psaltis AJ, Rabinowitz MR, Ramanathan M Jr, Rimmer R, Rosen MR, Sanusi O, Sargi ZB, Schafhausen P, Schlosser RJ, Sedaghat AR, Senior BA, Shrivastava R, Sindwani R, Smith TL, Smith KA, Snyderman CH, Solares CA, Sreenath SB, Stamm A, Stölzel K, Sumer B, Surda P, Tajudeen BA, Thompson LDR, Thorp BD, Tong CCL, Tsang RK, Turner JH, Turri-Zanoni M, Udager AM, van Zele T, VanKoevering K, Welch KC, Wise SK, Witterick IJ, Won TB, Wong SN, Woodworth BA, Wormald PJ, Yao WC, Yeh CF, Zhou B, Palmer JN
Int Forum Allergy Rhinol 2024 Feb;14(2):149-608. Epub 2024 Jan 2 doi: 10.1002/alr.23262. PMID: 37658764

Thyroid Nodules: Advances in Evaluation and Management.

Kant R, Davis A, Verma V
Am Fam Physician 2020 Sep 1;102(5):298-304. PMID: 32866364

Management Guidelines for Children with Thyroid Nodules and Differentiated Thyroid Cancer.

Francis GL, Waguespack SG, Bauer AJ, Angelos P, Benvenga S, Cerutti JM, Dinauer CA, Hamilton J, Hay ID, Luster M, Parisi MT, Rachmiel M, Thompson GB, Yamashita S; American Thyroid Association Guidelines Task Force
Thyroid 2015 Jul;25(7):716-59. doi: 10.1089/thy.2014.0460. PMID: 25900731 Free PMC Article

See all (314)

Recent clinical studies

Etiology

Evolution tumour models paving the way for understanding oral carcinogenesis.

Martins-Chaves RR, Silva RSO, Pereira TDSF, Fonseca FP, Gomez RS
J Oral Pathol Med 2023 Apr;52(4):294-299. Epub 2023 Jan 9 doi: 10.1111/jop.13402. PMID: 36622735

Pterygium-The Good, the Bad, and the Ugly.

Van Acker SI, Van den Bogerd B, Haagdorens M, Siozopoulou V, Ní Dhubhghaill S, Pintelon I, Koppen C
Cells 2021 Jun 22;10(7) doi: 10.3390/cells10071567. PMID: 34206333 Free PMC Article

Cutaneous Squamous Cell Carcinoma: From Biology to Therapy.

Corchado-Cobos R, García-Sancha N, González-Sarmiento R, Pérez-Losada J, Cañueto J
Int J Mol Sci 2020 Apr 22;21(8) doi: 10.3390/ijms21082956. PMID: 32331425 Free PMC Article

Non-squamous cell carcinoma diseases of the larynx: clinical and imaging findings.

Doğan S, Vural A, Kahriman G, İmamoğlu H, Abdülrezzak Ü, Öztürk M
Braz J Otorhinolaryngol 2020 Jul-Aug;86(4):468-482. Epub 2019 Mar 16 doi: 10.1016/j.bjorl.2019.02.003. PMID: 30956151 Free PMC Article

Cutaneous Squamous Cell Carcinoma.

Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498

See all (3665)

Diagnosis

Distinguishing Keratoacanthoma from Well-Differentiated Cutaneous Squamous Cell Carcinoma Using Single-Cell Spatial Pathology.

Veenstra J, Ozog D, Loveless I, Adrianto I, Dimitrion P, Subedi K, Friedman BJ, Zhou L, Mi QS
J Invest Dermatol 2023 Dec;143(12):2397-2407.e8. Epub 2023 Jul 5 doi: 10.1016/j.jid.2023.06.192. PMID: 37419445 Free PMC Article

Cutaneous Verrucous Carcinomas: A Review.

Ye Q, Jia M, Deng LJ, Fang S
J Cutan Med Surg 2023 Mar-Apr;27(2):150-156. Epub 2023 Feb 14 doi: 10.1177/12034754231155895. PMID: 36789508

Squamous Neoplasia in the Esophagus.

Savant D, Zhang Q, Yang Z
Arch Pathol Lab Med 2021 May 1;145(5):554-561. doi: 10.5858/arpa.2020-0058-RA. PMID: 32271610

Controversies in Oral and Maxillofacial Oncology.

Ettinger KS, Yetzer JG
Oral Maxillofac Surg Clin North Am 2017 Nov;29(4):487-501. doi: 10.1016/j.coms.2017.07.004. PMID: 28987229

Cutaneous Squamous Cell Carcinoma.

Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498

See all (5223)

Therapy

Cutaneous Squamous Cell Carcinoma.

Parekh V, Seykora JT
Clin Lab Med 2017 Sep;37(3):503-525. doi: 10.1016/j.cll.2017.06.003. PMID: 28802498

Keratoacanthoma: a distinct entity?

Gleich T, Chiticariu E, Huber M, Hohl D
Exp Dermatol 2016 Feb;25(2):85-91. Epub 2015 Dec 4 doi: 10.1111/exd.12880. PMID: 26476131

Revised American Thyroid Association management guidelines for patients with thyroid nodules and differentiated thyroid cancer.

American Thyroid Association (ATA) Guidelines Taskforce on Thyroid Nodules and Differentiated Thyroid Cancer, Cooper DS, Doherty GM, Haugen BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL, McIver B, Pacini F, Schlumberger M, Sherman SI, Steward DL, Tuttle RM
Thyroid 2009 Nov;19(11):1167-214. doi: 10.1089/thy.2009.0110. PMID: 19860577

Recurrent respiratory papillomatosis.

Tasca RA, Clarke RW
Arch Dis Child 2006 Aug;91(8):689-91. doi: 10.1136/adc.2005.090514. PMID: 16861486 Free PMC Article

Malignant anal tumours.

Deans GT, McAleer JJ, Spence RA
Br J Surg 1994 Apr;81(4):500-8. doi: 10.1002/bjs.1800810405. PMID: 8205420

See all (806)

Prognosis

Histomorphologic Profile of Skin Tumors.

Thapa R, Gurung P, Hirachand S, Shrestha SB
JNMA J Nepal Med Assoc 2018 Nov-Dec;56(214):953-957. doi: 10.31729/jnma.3988. PMID: 31065142 Free PMC Article

Bazex syndrome.

Rodrigues IA Jr, Gresta LT, Cruz RC, Carvalho GG, Moreira MH
An Bras Dermatol 2013 Nov-Dec;88(6 Suppl 1):209-11. doi: 10.1590/abd1806-4841.20132488. PMID: 24346922 Free PMC Article

Surgical pathology of lung cancer.

Rezaei MK, Nolan NJ, Schwartz AM
Semin Respir Crit Care Med 2013 Dec;34(6):770-86. Epub 2013 Nov 20 doi: 10.1055/s-0033-1358558. PMID: 24258567

Transhiatal esophagectomy.

Lin J, Iannettoni MD
Surg Clin North Am 2005 Jun;85(3):593-610. doi: 10.1016/j.suc.2005.01.009. PMID: 15927654

Intracranial inverting papilloma.

Miller PJ, Jacobs J, Roland JT Jr, Cooper J, Mizrachi HH
Head Neck 1996 Sep-Oct;18(5):450-3; discussion 454. doi: 10.1002/(SICI)1097-0347(199609/10)18:5<450::AID-HED8>3.0.CO;2-4. PMID: 8864736

See all (2656)

Clinical prediction guides

Histomorphologic Profile of Skin Tumors.

Thapa R, Gurung P, Hirachand S, Shrestha SB
JNMA J Nepal Med Assoc 2018 Nov-Dec;56(214):953-957. doi: 10.31729/jnma.3988. PMID: 31065142 Free PMC Article

Oral leukoplakia and oral cavity squamous cell carcinoma.

Bewley AF, Farwell DG
Clin Dermatol 2017 Sep-Oct;35(5):461-467. Epub 2017 Jun 27 doi: 10.1016/j.clindermatol.2017.06.008. PMID: 28916027

Role of diffusion-weighted imaging in head and neck lesions: Pictorial review.

Bhatt N, Gupta N, Soni N, Hooda K, Sapire JM, Kumar Y
Neuroradiol J 2017 Aug;30(4):356-369. Epub 2017 Jun 19 doi: 10.1177/1971400917708582. PMID: 28627953 Free PMC Article

Pleomorphic dermal neoplasms: a review.

Brenn T
Adv Anat Pathol 2014 Mar;21(2):108-30. doi: 10.1097/PAP.0000000000000009. PMID: 24508694

Imaging findings of papillary breast lesions: a pictorial review.

Kestelman FP, Gomes CF, Fontes FB, Marchiori E
Clin Radiol 2014 Apr;69(4):436-41. Epub 2014 Jan 20 doi: 10.1016/j.crad.2013.11.020. PMID: 24457016

See all (2383)

Recent systematic reviews

Systematic review of benefits and practical challenges for application of Mohs surgery for oral tumors.

Hussain A, Kim EY, Khachemoune A
Arch Dermatol Res 2023 Nov;315(9):2479-2484. Epub 2023 May 12 doi: 10.1007/s00403-023-02632-3. PMID: 37173597

Dermoscopy of cutaneous adnexal tumours: a systematic review of the literature.

Lai M, Muscianese M, Piana S, Chester J, Borsari S, Paolino G, Pellacani G, Longo C, Pampena R
J Eur Acad Dermatol Venereol 2022 Sep;36(9):1524-1540. Epub 2022 May 25 doi: 10.1111/jdv.18210. PMID: 35536546 Free PMC Article

Management of inverted papilloma: review.

Attlmayr B, Derbyshire SG, Kasbekar AV, Swift AC
J Laryngol Otol 2017 Apr;131(4):284-289. Epub 2017 Feb 9 doi: 10.1017/S0022215117000172. PMID: 28179032

Diagnostic Biomarkers in Oral Verrucous Carcinoma: A Systematic Review.

Hosseinpour S, Mashhadiabbas F, Ahsaie MG
Pathol Oncol Res 2017 Jan;23(1):19-32. Epub 2016 Dec 6 doi: 10.1007/s12253-016-0150-x. PMID: 27924463

Sphingosine kinase 1 and cancer: a systematic review and meta-analysis.

Zhang Y, Wang Y, Wan Z, Liu S, Cao Y, Zeng Z
PLoS One 2014;9(2):e90362. Epub 2014 Feb 27 doi: 10.1371/journal.pone.0090362. PMID: 24587339 Free PMC Article

See all (45)

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Benign Squamous Cell Neoplasm

Definition

Term Hierarchy

Professional guidelines

PubMed

Recent clinical studies

Etiology

Diagnosis

Therapy

Prognosis

Clinical prediction guides

Recent systematic reviews

Supplemental Content

Table of contents

Practice guidelines

Related information

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