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Eyelid Squamous Papilloma

MedGen UID:
90936
•Concept ID:
C0339108
•
Neoplastic Process
Synonyms: Epidermoid Papilloma of Eyelid; Epidermoid Papilloma of the Eyelid; Eyelid Epidermoid Papilloma; Eyelid Squamous Cell Papilloma; Squamous cell papilloma of eyelid; Squamous Cell Papilloma of Eyelid; Squamous Cell Papilloma of the Eyelid
SNOMED CT: Squamous cell papilloma of eyelid (231825000)

Definition

A papilloma that arises from the eyelid. It is composed of squamous cells and is characterized by the presence of an acanthotic epithelium with hyperkeratosis and papillary projections with an inner fibrovascular core. It is the most common benign epithelial tumor of eyelid. It usually affects middle-aged or older adults. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEyelid Squamous Papilloma

Professional guidelines

PubMed

Evaluation and management of benign tumors of the eye and eyelid.
Brown R, Fard S, Feng P, Kerr PE
Clin Dermatol 2024 Jul-Aug;42(4):343-350. Epub 2024 Jan 26 doi: 10.1016/j.clindermatol.2024.01.005. PMID: 38281689
Resolution of a Presumed Conjunctival Papilloma After Therapeutic Treatment With the Human Papillomavirus Vaccine.
Sripawadkul W, AlBayyat G, Galor A, Wylegala A, Nichols AJ, Ioannides T, Karp CL
JAMA Ophthalmol 2022 Apr 1;140(4):434-435. doi: 10.1001/jamaophthalmol.2021.6334. PMID: 35175310
Treatment of benign eyelid lesions with Nd:YVO laser: a prospective study.
Sousa-Neves F, Cardoso da Costa J, Braga J, Prazeres S
J Cosmet Laser Ther 2020 Apr 2;22(3):146-149. Epub 2020 Jun 4 doi: 10.1080/14764172.2020.1767787. PMID: 32496946

Recent clinical studies

Etiology

Blood-stained tears-a red flag for malignancy?
Kaushik M, Juniat V, Ezra DG, Verity DH, Uddin J, Timlin H
Eye (Lond) 2023 Jun;37(8):1711-1716. Epub 2022 Sep 10 doi: 10.1038/s41433-022-02224-x. PMID: 36088421Free PMC Article
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Conjunctival Exophytic Schneiderian-type Papillomas: A Rare Occurrence.
Charles NC, Stagner AM, Raju LV, Belinsky I
Ophthalmic Plast Reconstr Surg 2021 Sep-Oct 01;37(5):e179-e181. doi: 10.1097/IOP.0000000000001983. PMID: 34284422
Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article

Diagnosis

Conjunctival Papilloma.
Liu Z, Lin Y
N Engl J Med 2024 Jul 18;391(3):259. doi: 10.1056/NEJMicm2401200. PMID: 39018535
Evaluation and management of benign tumors of the eye and eyelid.
Brown R, Fard S, Feng P, Kerr PE
Clin Dermatol 2024 Jul-Aug;42(4):343-350. Epub 2024 Jan 26 doi: 10.1016/j.clindermatol.2024.01.005. PMID: 38281689
Eyelid Papilloma.
Lai CC, Lee WA
Ophthalmology 2024 Feb;131(2):226. Epub 2023 Jun 1 doi: 10.1016/j.ophtha.2023.05.005. PMID: 37269263
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article

Therapy

Resolution of a Presumed Conjunctival Papilloma After Therapeutic Treatment With the Human Papillomavirus Vaccine.
Sripawadkul W, AlBayyat G, Galor A, Wylegala A, Nichols AJ, Ioannides T, Karp CL
JAMA Ophthalmol 2022 Apr 1;140(4):434-435. doi: 10.1001/jamaophthalmol.2021.6334. PMID: 35175310
Interferon alfa-2b in the management of recurrent conjunctival papillomatosis.
Singh M, Gautam N, Gupta A, Kaur M
Indian J Ophthalmol 2016 Oct;64(10):778-780. doi: 10.4103/0301-4738.195013. PMID: 27905345Free PMC Article
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article
Argon laser therapy of benign tumors of the eyelid.
Wohlrab TM, Rohrbach JM, Erb C, Schlote T, Knorr M, Thiel HJ
Am J Ophthalmol 1998 May;125(5):693-7. doi: 10.1016/s0002-9394(98)00004-x. PMID: 9625554
Biomicroscopy of papillae associated with hard contact lens wearing.
Korb DR, Allansmith MR, Greiner JV, Henriquez AS, Herman JP, Richmond PP, Finnemore VM
Ophthalmology 1981 Nov;88(11):1132-6. doi: 10.1016/s0161-6420(81)34899-4. PMID: 7335320

Prognosis

Clinical features and factors affecting prognosis and partial deterioration of ocular papilloma: a retrospective study of 298 cases.
Jian H, He W
Graefes Arch Clin Exp Ophthalmol 2023 Aug;261(8):2395-2402. Epub 2023 Mar 18 doi: 10.1007/s00417-023-06035-y. PMID: 36933010
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Conjunctival intraepithelial neoplasia and carcinoma: distinct clinical and histological features in relation to human papilloma virus status.
Ramberg I, Toft PB, Georgsen JB, Siersma VD, Funding M, Jensen DH, von Buchwald C, Heegaard S
Br J Ophthalmol 2021 Jun;105(6):878-883. Epub 2019 Oct 24 doi: 10.1136/bjophthalmol-2019-315011. PMID: 31649051
Periocular inverted follicular keratosis: a retrospective series over 17 years.
Díez-Montero C, González González D, Pérez Martínez E, Schellini S, Galindo-Ferreiro A
Jpn J Ophthalmol 2019 Mar;63(2):210-214. Epub 2019 Jan 2 doi: 10.1007/s10384-018-00650-7. PMID: 30604112
Epidemiology of ocular surface squamous neoplasia in Africa.
Gichuhi S, Sagoo MS, Weiss HA, Burton MJ
Trop Med Int Health 2013 Dec;18(12):1424-43. Epub 2013 Oct 30 doi: 10.1111/tmi.12203. PMID: 24237784Free PMC Article

Clinical prediction guides

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
p16INK4A expression is frequently increased in periorbital and ocular squamous lesions.
Kobalka PJ, Abboud JP, Liao X, Jones K, Lee BW, Korn BS, Kikkawa DO, Lin JH
Diagn Pathol 2015 Sep 24;10:175. doi: 10.1186/s13000-015-0396-8. PMID: 26400483Free PMC Article
Papillary hidradenoma of the eyelid margin: clinical and immunohistochemical observations further supporting an apocrine rather than an eccrine origin.
Jakobiec FA, Rai R, Lefebvre DR
Surv Ophthalmol 2014 Sep-Oct;59(5):540-7. Epub 2014 Jan 28 doi: 10.1016/j.survophthal.2014.01.002. PMID: 24661803
Clinicopathological features of eyelid skin tumors. A retrospective study of 5504 cases and review of literature.
Deprez M, Uffer S
Am J Dermatopathol 2009 May;31(3):256-62. doi: 10.1097/DAD.0b013e3181961861. PMID: 19384066

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