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Squamous cell skin papilloma

MedGen UID:
83397
•Concept ID:
C0345983
•
Neoplastic Process
Synonyms: Dyskeratotic papilloma of skin; Dyskeratotic papilloma of the skin; Dyskeratotic skin papilloma; Hyperkeratotic papilloma of skin; hyperkeratotic papilloma of skin; hyperkeratotic papilloma of the skin; hyperkeratotic skin papilloma; Parakeratotic papilloma of skin; parakeratotic papilloma of skin; parakeratotic papilloma of the skin; parakeratotic skin papilloma; Squamous cell papilloma of skin; squamous cell papilloma of skin; squamous cell papilloma of the skin; squamous cell skin papilloma; zone of skin squamous papilloma
SNOMED CT: Squamous cell papilloma of skin (254661000); Parakeratotic papilloma of skin (254661000); Hyperkeratotic papilloma of skin (254661000); Dyskeratotic papilloma of skin (254661000)
 
Monarch Initiative: MONDO:0004204

Definition

A squamous papilloma that involves the zone of skin. [from MONDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVSquamous cell skin papilloma

Professional guidelines

PubMed

Pathophysiology, Histopathology, and Differential Diagnostics of Basal Cell Carcinoma and Cutaneous Squamous Cell Carcinoma-An Update from the Pathologist's Point of View.
Cocuz IG, Popelea MC, Niculescu R, Manea A, Sabău AH, Tinca AC, Szoke AR, Budin CE, Stoian A, Morariu SH, Cotoi TC, Cocuz ME, Cotoi OS
Int J Mol Sci 2024 Feb 13;25(4) doi: 10.3390/ijms25042220. PMID: 38396897Free PMC Article
STING expression and response to treatment with STING ligands in premalignant and malignant disease.
Baird JR, Feng Z, Xiao HD, Friedman D, Cottam B, Fox BA, Kramer G, Leidner RS, Bell RB, Young KH, Crittenden MR, Gough MJ
PLoS One 2017;12(11):e0187532. Epub 2017 Nov 14 doi: 10.1371/journal.pone.0187532. PMID: 29135982Free PMC Article
Longitudinal Erythronychia: Retrospective Single-Center Study Evaluating Differential Diagnosis and the Likelihood of Malignancy.
Jellinek NJ, Lipner SR
Dermatol Surg 2016 Mar;42(3):310-9. doi: 10.1097/DSS.0000000000000594. PMID: 26918968

Recent clinical studies

Etiology

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Molecular Biology of Basal and Squamous Cell Carcinomas.
Boeckmann L, Martens MC, Emmert S
Adv Exp Med Biol 2020;1268:171-191. doi: 10.1007/978-3-030-46227-7_9. PMID: 32918219
The low-risk papillomaviruses.
Egawa N, Doorbar J
Virus Res 2017 Mar 2;231:119-127. Epub 2016 Dec 28 doi: 10.1016/j.virusres.2016.12.017. PMID: 28040475
Human papillomavirus and immunosuppression.
Wieland U, Kreuter A, Pfister H
Curr Probl Dermatol 2014;45:154-65. Epub 2014 Mar 13 doi: 10.1159/000357907. PMID: 24643184
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Diagnosis

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Clinical and pathological diagnosis and comparison of benign and malignant eyelid tumors.
Sendul SY, Akpolat C, Yilmaz Z, Eryilmaz OT, Guven D, Kabukcuoglu F
J Fr Ophtalmol 2021 Apr;44(4):537-543. Epub 2021 Feb 18 doi: 10.1016/j.jfo.2020.07.019. PMID: 33610396
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Pigmented condyloma acuminatum.
Shimizu A, Kato M, Ishikawa O
J Dermatol 2014 Apr;41(4):337-9. Epub 2014 Feb 24 doi: 10.1111/1346-8138.12428. PMID: 24611994
IκB kinase alpha and cancer.
Liu S, Chen Z, Zhu F, Hu Y
J Interferon Cytokine Res 2012 Apr;32(4):152-8. Epub 2011 Dec 7 doi: 10.1089/jir.2011.0107. PMID: 22149351Free PMC Article

Therapy

Isolation of cancer stem cells from skin squamous cell carcinoma.
Joshi P, Ghadi DS, Waghmare SK
Methods Cell Biol 2022;171:63-80. Epub 2022 Jul 21 doi: 10.1016/bs.mcb.2022.06.002. PMID: 35953206
UV and Reactive Oxygen Species Activate Human Papillomaviruses Causing Skin Cancers.
Godar DE
Curr Probl Dermatol 2021;55:339-353. Epub 2021 Oct 25 doi: 10.1159/000517643. PMID: 34698023
Organ transplantation and skin--principles and concepts.
Hofbauer GF, Freiberger SN, Iotzova-Weiss G, Shafaeddin B, Dziunycz PJ
Curr Probl Dermatol 2012;43:1-8. Epub 2012 Feb 17 doi: 10.1159/000335137. PMID: 22377915
Large-cell acanthoma.
Weinstock MA
Am J Dermatopathol 1992 Apr;14(2):133-4; discussion 135. doi: 10.1097/00000372-199204000-00007. PMID: 1566973
Desmoplastic trichilemmoma.
Tellechea O, Reis JP, Baptista AP
Am J Dermatopathol 1992 Apr;14(2):107-4. doi: 10.1097/00000372-199204000-00004. PMID: 1373583

Prognosis

WHO 2022 classification of penile and scrotal cancers: updates and evolution.
Menon S, Moch H, Berney DM, Cree IA, Srigley JR, Tsuzuki T, Compérat E, Hartmann A, Netto G, Rubin MA, Gill AJ, Turajlic S, Tan PH, Raspollini MR, Tickoo SK, Amin MB
Histopathology 2023 Mar;82(4):508-520. Epub 2022 Nov 9 doi: 10.1111/his.14824. PMID: 36221864
Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Post-renal transplant malignancies: Opportunities for prevention and early screening.
Turshudzhyan A
Cancer Treat Res Commun 2021;26:100283. Epub 2020 Dec 11 doi: 10.1016/j.ctarc.2020.100283. PMID: 33338850
Claw foot A case report.
Innocenti A, Ciancio F, Taverna C, Tanini S, Portincasa A, Parisi D, Innocenti M, De Giorgi V
Ann Ital Chir 2017;88:368-370. PMID: 28632148
Lichen sclerosus and squamous cell carcinoma.
Gutiérrez-Pascual M, Vicente-Martín FJ, López-Estebaranz JL
Actas Dermosifiliogr 2012 Jan;103(1):21-8. Epub 2012 Mar 24 doi: 10.1016/j.adengl.2011.05.004. PMID: 22445563

Clinical prediction guides

Human Papillomavirus Related Neoplasia of the Ocular Adnexa.
Ramberg I, Heegaard S
Viruses 2021 Aug 2;13(8) doi: 10.3390/v13081522. PMID: 34452388Free PMC Article
Human papillomavirus infection and ocular surface disease (Review).
Chalkia AK, Bontzos G, Spandidos DA, Detorakis ET
Int J Oncol 2019 May;54(5):1503-1510. Epub 2019 Mar 19 doi: 10.3892/ijo.2019.4755. PMID: 30896784Free PMC Article
Claw foot A case report.
Innocenti A, Ciancio F, Taverna C, Tanini S, Portincasa A, Parisi D, Innocenti M, De Giorgi V
Ann Ital Chir 2017;88:368-370. PMID: 28632148
Pigmented condyloma acuminatum.
Shimizu A, Kato M, Ishikawa O
J Dermatol 2014 Apr;41(4):337-9. Epub 2014 Feb 24 doi: 10.1111/1346-8138.12428. PMID: 24611994
Skin precancer.
Brash DE, Pontén J
Cancer Surv 1998;32:69-113. PMID: 10489624

Recent systematic reviews

Benefits and challenges of Mohs micrographic surgery for human papilloma virus-associated cutaneous malignancies: a systematic review.
Riva HR, Yoon T, Mohammad K Shalabi M, Hussain A, Khachemoune A
Arch Dermatol Res 2024 Sep 14;316(9):617. doi: 10.1007/s00403-024-03364-8. PMID: 39276166
The risk of dermatological toxicities of combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma patients: a systematic review and meta-analysis.
Chen P, Chen F, Zhou B
Cutan Ocul Toxicol 2019 Jun;38(2):105-111. Epub 2019 Jan 28 doi: 10.1080/15569527.2018.1553180. PMID: 30501438

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