U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Larynx squamous papilloma

MedGen UID:
116099
•Concept ID:
C0240164
•
Neoplastic Process
Synonyms: Laryngeal Papilloma; laryngeal papilloma; Laryngeal Squamous Cell Papilloma; Laryngeal Squamous Papilloma; Larynx Papilloma; larynx papilloma; larynx squamous papilloma; Papilloma of Larynx; papilloma of larynx; Papilloma of the Larynx; papilloma of the larynx; Squamous Papilloma of Larynx; squamous papilloma of larynx; Squamous Papilloma of the Larynx; squamous papilloma of the larynx
 
Monarch Initiative: MONDO:0000935

Definition

A benign exophytic neoplasm that arises from the larynx, usually the true vocal cords. It is related to human papillomavirus infection and may arise as a single or multiple lesions. It is characterized by the presence of a connective tissue core covered by stratified squamous epithelium. Hoarseness is the presenting symptom. Transformation to carcinoma is rare. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLarynx squamous papilloma

Professional guidelines

PubMed

Cancer of unknown primary in the head and neck: Diagnosis and treatment.
Ota I, Kitahara T
Auris Nasus Larynx 2021 Feb;48(1):23-31. Epub 2020 Sep 1 doi: 10.1016/j.anl.2020.08.014. PMID: 32888761
Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review.
Winquist E, Agbassi C, Meyers BM, Yoo J, Chan KKW; Head and Neck Disease Site Group
J Otolaryngol Head Neck Surg 2017 Apr 4;46(1):29. doi: 10.1186/s40463-017-0199-x. PMID: 28376866Free PMC Article
Clinical management of squamous cell carcinoma associated with sinonasal inverted papilloma.
Yasumatsu R, Nakashima T, Sato M, Nakano T, Kogo R, Hashimoto K, Sawatsubashi M, Nakagawa T
Auris Nasus Larynx 2017 Feb;44(1):98-103. Epub 2016 Jun 1 doi: 10.1016/j.anl.2016.04.004. PMID: 27108101

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

Recent clinical studies

Etiology

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
p53 mutations in oral cavity carcinoma.
Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P
J BUON 2018 Nov-Dec;23(6):1569-1572. PMID: 30610778
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Cancer of the oropharynx.
Clump DA, Bauman JE, Ferris RL
Surg Oncol Clin N Am 2015 Jul;24(3):509-20. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.014. PMID: 25979397
Juvenile-onset recurrent respiratory papillomatosis.
Maturo SC, Hartnick CJ
Adv Otorhinolaryngol 2012;73:105-8. Epub 2012 Mar 29 doi: 10.1159/000334457. PMID: 22472239

Diagnosis

Laryngeal verrucous cell carcinoma.
Lechien JR, Vaira LA, Chiesa-Estomba CM
Curr Opin Otolaryngol Head Neck Surg 2024 Apr 1;32(2):118-124. Epub 2023 Oct 10 doi: 10.1097/MOO.0000000000000910. PMID: 37820109
Recurrent Respiratory Papilloma of the Larynx.
Huston MN, Naunheim MR, Sadow PM
Mayo Clin Proc 2023 Jun;98(6):945-946. doi: 10.1016/j.mayocp.2023.02.011. PMID: 37270273
Update on Neuroendocrine Carcinomas of the Larynx.
Strosberg C, Ferlito A, Triantafyllou A, Gnepp DR, Bishop JA, Hellquist H, Strojan P, Willems SM, Stenman G, Rinaldo A, Hernandez-Prera JC
Am J Clin Pathol 2019 Nov 4;152(6):686-700. doi: 10.1093/ajcp/aqz106. PMID: 31415081
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Adult laryngotracheal surgery.
Xiao P, Zhang XS
Anesthesiol Clin 2010 Sep;28(3):529-40. doi: 10.1016/j.anclin.2010.07.010. PMID: 20850083

Therapy

Infantile recurrent respiratory papillomatosis: review of adjuvant therapies.
Patel A, Orban N
J Laryngol Otol 2021 Nov;135(11):958-963. Epub 2021 Sep 2 doi: 10.1017/S0022215121002322. PMID: 34470689
Therapeutic Vaccines Against Human Papilloma Viruses: Achievements and Prospects.
Vonsky MS, Runov AL, Gordeychuk IV, Isaguliants MG
Biochemistry (Mosc) 2019 Jul;84(7):800-816. doi: 10.1134/S0006297919070101. PMID: 31509730
Precision medicine in head and neck cancer.
Kaidar-Person O, Gil Z, Billan S
Drug Resist Updat 2018 Sep;40:13-16. Epub 2018 Sep 25 doi: 10.1016/j.drup.2018.09.001. PMID: 30466712
Recurrent respiratory papillomatosis.
Venkatesan NN, Pine HS, Underbrink MP
Otolaryngol Clin North Am 2012 Jun;45(3):671-94, viii-ix. doi: 10.1016/j.otc.2012.03.006. PMID: 22588043Free PMC Article
Therapy for recurrent respiratory papillomatosis.
Auborn KJ
Antivir Ther 2002 Mar;7(1):1-9. PMID: 12008782

Prognosis

Laryngeal verrucous cell carcinoma.
Lechien JR, Vaira LA, Chiesa-Estomba CM
Curr Opin Otolaryngol Head Neck Surg 2024 Apr 1;32(2):118-124. Epub 2023 Oct 10 doi: 10.1097/MOO.0000000000000910. PMID: 37820109
Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614
Recurrent respiratory papillomatosis: A state-of-the-art review.
Fortes HR, von Ranke FM, Escuissato DL, Araujo Neto CA, Zanetti G, Hochhegger B, Souza CA, Marchiori E
Respir Med 2017 May;126:116-121. Epub 2017 Apr 1 doi: 10.1016/j.rmed.2017.03.030. PMID: 28427542
Cancer of the oropharynx.
Clump DA, Bauman JE, Ferris RL
Surg Oncol Clin N Am 2015 Jul;24(3):509-20. Epub 2015 Apr 15 doi: 10.1016/j.soc.2015.03.014. PMID: 25979397

Clinical prediction guides

Recurrent laryngeal papillomatosis: multimodal therapeutic strategies. Literature review and multicentre retrospective study.
Bertino G, Pedretti F, Mauramati S, Filauro M, Vallin A, Mora F, Crosetti E, Succo G, Peretti G, Benazzo M
Acta Otorhinolaryngol Ital 2023 Apr;43(Suppl. 1):S111-S122. doi: 10.14639/0392-100X-suppl.1-43-2023-14. PMID: 37698108Free PMC Article
NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review.
Saraniti C, Gallina S, Verro B
Int J Environ Res Public Health 2022 Jul 18;19(14) doi: 10.3390/ijerph19148716. PMID: 35886569Free PMC Article
p53 mutations in oral cavity carcinoma.
Ragos V, S Mastronikolis N, Tsiambas E, Baliou E, N Mastronikolis S, Tsoukalas N, E Patsouri E, P Fotiades P
J BUON 2018 Nov-Dec;23(6):1569-1572. PMID: 30610778
Clinical features of nasal and sinonasal inverted papilloma associated with malignancy.
Miyazaki T, Haku Y, Yoshizawa A, Iwanaga K, Fujiwara T, Mizuta M, Yoshida A, Satou S, Tamaki H
Auris Nasus Larynx 2018 Oct;45(5):1014-1019. Epub 2018 Mar 13 doi: 10.1016/j.anl.2018.02.009. PMID: 29548524
Head and neck squamous cell carcinoma: Genomics and emerging biomarkers for immunomodulatory cancer treatments.
Solomon B, Young RJ, Rischin D
Semin Cancer Biol 2018 Oct;52(Pt 2):228-240. Epub 2018 Jan 31 doi: 10.1016/j.semcancer.2018.01.008. PMID: 29355614

Recent systematic reviews

NBI and Laryngeal Papillomatosis: A Diagnostic Challenge: A Systematic Review.
Saraniti C, Gallina S, Verro B
Int J Environ Res Public Health 2022 Jul 18;19(14) doi: 10.3390/ijerph19148716. PMID: 35886569Free PMC Article
Bevacizumab as treatment option for recurrent respiratory papillomatosis: a systematic review.
Pogoda L, Ziylan F, Smeeing DPJ, Dikkers FG, Rinkel RNPM
Eur Arch Otorhinolaryngol 2022 Sep;279(9):4229-4240. Epub 2022 Apr 24 doi: 10.1007/s00405-022-07388-6. PMID: 35462578Free PMC Article
Involvement of Laryngopharyngeal Reflux in Select Nonfunctional Laryngeal Diseases: A Systematic Review.
Lechien JR, Akst LM, Saussez S, Crevier-Buchman L, Hans S, Barillari MR, Calvo-Henriquez C, Bock JM, Carroll TL
Otolaryngol Head Neck Surg 2021 Jan;164(1):37-48. Epub 2020 Jun 23 doi: 10.1177/0194599820933209. PMID: 32571152
Systemic therapy in the curative treatment of head and neck squamous cell cancer: a systematic review.
Winquist E, Agbassi C, Meyers BM, Yoo J, Chan KKW; Head and Neck Disease Site Group
J Otolaryngol Head Neck Surg 2017 Apr 4;46(1):29. doi: 10.1186/s40463-017-0199-x. PMID: 28376866Free PMC Article

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®), Head and Neck Cancers, 2024

    Consumer resources

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...