GEO Logo
   NCBI > GEO > Accession DisplayHelp Not logged in | LoginHelp
GEO help: Mouse over screen elements for information.
Series GSE48113 Query DataSets for GSE48113
Status Public on Jan 23, 2014
Title Mistimed sleep disrupts circadian regulation of the human blood transcriptome
Organism Homo sapiens
Experiment type Expression profiling by array
Summary 22 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake cycle and the associated fasting-feeding cycle is scheduled to a 28-hour period, of which one third (i.e. 9h 20min) is scheduled for sleep. Under these conditions, during which light levels in the waking episode are kept low and sleep is scheduled in darkness, the phase of the melatonin rhythm occurred at approximately the same clock time during the first (D1) and fourth (D4) 28-h cycle and there were no major changes in either the amplitude or the waveform of this rhythm. During D1 and D4 7 blood samples were taken, RNA was extracted from leukocytes, labelled and hybridised to human whole-genome microarrays
Overall design A total of 287 samples comprising 22 human subjects, for which 14 samples across multiple time-points/sleep condition were collected.
Contributor(s) Moller-Levet C, Archer S, Bucca G, Laing E, Slak A, Kabiljo R, van der Veen D, Lazar A, Groeger J, Santhi N, von Schantz M, Smith CP, Dijk DJ
Citation(s) 24449876, 36060675
Submission date Jun 19, 2013
Last update date Sep 15, 2022
Contact name Emma Laing
Organization name University of Surrey
Street address Stag Hill
City Guildford
ZIP/Postal code GU22 7XH
Country United Kingdom
Platforms (1)
GPL15331 Agilent-026817 University_Surrey_HumanSleep_44k_v1
Samples (287)
GSM1168586 Blood_TakenInPhaseWithRespectToMelatonin_at22:15_Per3_5\5genotype_Subject_BB0012_R_T1
GSM1168587 Blood_TakenInPhaseWithRespectToMelatonin_at02:10_Per3_5\5genotype_Subject_BB0012_R_T2
GSM1168588 Blood_TakenInPhaseWithRespectToMelatonin_at06:15_Per3_5\5genotype_Subject_BB0012_R_T3
BioProject PRJNA208941

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE48113_RAW.tar 2.4 Gb (http)(custom) TAR (of TXT)
Processed data included within Sample table

| NLM | NIH | GEO Help | Disclaimer | Accessibility |
NCBI Home NCBI Search NCBI SiteMap