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| Status |
Public on Jun 15, 2021 |
| Title |
Disruption of Y chromosome expression in male lung cancer: discovery |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
Lung cancer is the single most frequent cause of cancer death worldwide and is relatively more common in males. For reasons that are currently unknown, lung cancer is also associated with significantly worse outcomes in men than women. Here we examine the pulmonary transcriptome in lung cancer at a systems level through network analysis. We compare gene expression networks in affected and unaffected tissue derived from 126 patients with lung cancer. Examination of tissue-specific co-expression patterns reveals markedly poor preservation of a sex-associated gene co-expression network in tumor tissue.
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| Overall design |
Human whole transcriptome data were generated from pulmonary tumor and, where possible, matched unaffected tissue (referred to hereon as ‘normal’) using the Affymetrix HuGene 1.1 ST microarray, giving a total of 237 samples from 126 patients. Tumor samples and adjacent normal lung tissue were donated from surgical resections, undertaken with curative intent.
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| Contributor(s) |
Arseneault M, Cookson WO, Domingo Sabugo C, Freidin MB, Kiong Lu S, Lathrop M, Liang L, Lim E, Moffatt MF, Nicholson AG, Popat S, Riazalhosseini Y, Starren E, Willis-Owen SA, Zhang Y |
| Citation(s) |
34127738 |
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| Submission date |
May 23, 2020 |
| Last update date |
Nov 16, 2021 |
| Contact name |
William Cookson |
| E-mail(s) |
w.cookson@imperial.ac.uk
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| Organization name |
Imperial College London
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| Street address |
Dovehouse Street
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| City |
London |
| ZIP/Postal code |
SW3 6LY |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL11532 |
[HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version] |
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| Samples (237)
|
| GSM4566333 |
Sample 1288 (Lung, Tumor) |
| GSM4566334 |
Sample 222 (Lung, Tumor) |
| GSM4566335 |
Sample 476 (Lung, Tumor) |
| GSM4566336 |
Sample 64 (Lung, Tumor) |
| GSM4566337 |
Sample 677 (Lung, Tumor) |
| GSM4566338 |
Sample 832 (Lung, Tumor) |
| GSM4566339 |
Sample 885 (Lung, Tumor) |
| GSM4566340 |
Sample 954 (Lung, Tumor) |
| GSM4566341 |
Sample 851 (Lung, Tumor) |
| GSM4566342 |
Sample 00328 (Lung, Tumor) |
| GSM4566343 |
Sample 1276 (Lung, Tumor) |
| GSM4566344 |
Sample 1303 (Lung, Tumor) |
| GSM4566345 |
Sample 250 (Lung, Tumor) |
| GSM4566346 |
Sample 379 (Lung, Tumor) |
| GSM4566347 |
Sample 469 (Lung, Tumor) |
| GSM4566348 |
Sample 73 (Lung, Tumor) |
| GSM4566349 |
Sample 835 (Lung, Tumor) |
| GSM4566350 |
Sample 983 (Lung, Tumor) |
| GSM4566351 |
Sample 00356 (Lung, Tumor) |
| GSM4566352 |
Sample 00408 (Lung, Tumor) |
| GSM4566353 |
Sample 1254 (Lung, Tumor) |
| GSM4566354 |
Sample 388 (Lung, Tumor) |
| GSM4566355 |
Sample 631 (Lung, Tumor) |
| GSM4566356 |
Sample 965 (Lung, Tumor) |
| GSM4566357 |
Sample 00304 (Lung, Normal) |
| GSM4566358 |
Sample 00443 (Lung, Normal) |
| GSM4566359 |
Sample 1008 (Lung, Normal) |
| GSM4566360 |
Sample 1288 (Lung, Normal) |
| GSM4566361 |
Sample 222 (Lung, Normal) |
| GSM4566362 |
Sample 476 (Lung, Normal) |
| GSM4566363 |
Sample 64 (Lung, Normal) |
| GSM4566364 |
Sample 677 (Lung, Normal) |
| GSM4566365 |
Sample 832 (Lung, Normal) |
| GSM4566366 |
Sample 885 (Lung, Normal) |
| GSM4566367 |
Sample 954 (Lung, Normal) |
| GSM4566368 |
Sample 851 (Lung, Normal) |
| GSM4566369 |
Sample 00328 (Lung, Normal) |
| GSM4566370 |
Sample 1276 (Lung, Normal) |
| GSM4566371 |
Sample 1303 (Lung, Normal) |
| GSM4566372 |
Sample 250 (Lung, Normal) |
| GSM4566373 |
Sample 379 (Lung, Normal) |
| GSM4566374 |
Sample 606 (Lung, Normal) |
| GSM4566375 |
Sample 73 (Lung, Normal) |
| GSM4566376 |
Sample 835 (Lung, Normal) |
| GSM4566377 |
Sample 889 (Lung, Normal) |
| GSM4566378 |
Sample 983 (Lung, Normal) |
| GSM4566379 |
Sample 826 (Lung, Tumor) |
| GSM4566380 |
Sample 00356 (Lung, Normal) |
| GSM4566381 |
Sample 00408 (Lung, Normal) |
| GSM4566382 |
Sample 1259 (Lung, Tumor) |
| GSM4566383 |
Sample 388 (Lung, Normal) |
| GSM4566384 |
Sample 631 (Lung, Normal) |
| GSM4566385 |
Sample 965 (Lung, Normal) |
| GSM4566386 |
Sample 00306 (Lung, Tumor) |
| GSM4566387 |
Sample 00449 (Lung, Tumor) |
| GSM4566388 |
Sample 1023 (Lung, Tumor) |
| GSM4566389 |
Sample 1289 (Lung, Tumor) |
| GSM4566390 |
Sample 23 (Lung, Tumor) |
| GSM4566391 |
Sample 490 (Lung, Tumor) |
| GSM4566392 |
Sample 662 (Lung, Tumor) |
| GSM4566393 |
Sample 687 (Lung, Tumor) |
| GSM4566394 |
Sample 696 (Lung, Tumor) |
| GSM4566395 |
Sample 941 (Lung, Tumor) |
| GSM4566396 |
Sample 00345 (Lung, Tumor) |
| GSM4566397 |
Sample 1241 (Lung, Tumor) |
| GSM4566398 |
Sample 1279 (Lung, Tumor) |
| GSM4566399 |
Sample 253 (Lung, Tumor) |
| GSM4566400 |
Sample 380 (Lung, Tumor) |
| GSM4566401 |
Sample 470 (Lung, Tumor) |
| GSM4566402 |
Sample 615 (Lung, Tumor) |
| GSM4566403 |
Sample 806 (Lung, Tumor) |
| GSM4566404 |
Sample 878 (Lung, Tumor) |
| GSM4566405 |
Sample 925 (Lung, Tumor) |
| GSM4566406 |
Sample 988 (Lung, Tumor) |
| GSM4566407 |
Sample 826 (Lung, Normal) |
| GSM4566408 |
Sample 00362 (Lung, Tumor) |
| GSM4566409 |
Sample 1011 (Lung, Tumor) |
| GSM4566410 |
Sample 1270 (Lung, Tumor) |
| GSM4566411 |
Sample 413 (Lung, Tumor) |
| GSM4566412 |
Sample 634 (Lung, Tumor) |
| GSM4566413 |
Sample 937 (Lung, Tumor) |
| GSM4566414 |
Sample 00306 (Lung, Normal) |
| GSM4566415 |
Sample 00449 (Lung, Normal) |
| GSM4566416 |
Sample 1023 (Lung, Normal) |
| GSM4566417 |
Sample 1289 (Lung, Normal) |
| GSM4566418 |
Sample 23 (Lung, Normal) |
| GSM4566419 |
Sample 490 (Lung, Normal) |
| GSM4566420 |
Sample 662 (Lung, Normal) |
| GSM4566421 |
Sample 687 (Lung, Normal) |
| GSM4566422 |
Sample 696 (Lung, Normal) |
| GSM4566423 |
Sample 834 (Lung, Normal) |
| GSM4566424 |
Sample 941 (Lung, Normal) |
| GSM4566425 |
Sample 00013 (Lung, Normal) |
| GSM4566426 |
Sample 00345 (Lung, Normal) |
| GSM4566427 |
Sample 1241 (Lung, Normal) |
| GSM4566428 |
Sample 1279 (Lung, Normal) |
| GSM4566429 |
Sample 253 (Lung, Normal) |
| GSM4566430 |
Sample 380 (Lung, Normal) |
| GSM4566431 |
Sample 480 (Lung, Normal) |
| GSM4566432 |
Sample 615 (Lung, Normal) |
| GSM4566433 |
Sample 806 (Lung, Normal) |
| GSM4566434 |
Sample 878 (Lung, Normal) |
| GSM4566435 |
Sample 925 (Lung, Normal) |
| GSM4566436 |
Sample 988 (Lung, Normal) |
| GSM4566437 |
Sample 999 (Lung, Tumor) |
| GSM4566438 |
Sample 00362 (Lung, Normal) |
| GSM4566439 |
Sample 1011 (Lung, Normal) |
| GSM4566440 |
Sample 224 (Lung, Tumor) |
| GSM4566441 |
Sample 413 (Lung, Normal) |
| GSM4566442 |
Sample 622 (Lung, Normal) |
| GSM4566443 |
Sample 634 (Lung, Normal) |
| GSM4566444 |
Sample 937 (Lung, Normal) |
| GSM4566445 |
Sample 00319 (Lung, Tumor) |
| GSM4566446 |
Sample 1012 (Lung, Tumor) |
| GSM4566447 |
Sample 1022 (Lung, Tumor) |
| GSM4566448 |
Sample 1246 (Lung, Tumor) |
| GSM4566449 |
Sample 208 (Lung, Tumor) |
| GSM4566450 |
Sample 243 (Lung, Tumor) |
| GSM4566451 |
Sample 493 (Lung, Tumor) |
| GSM4566452 |
Sample 681 (Lung, Tumor) |
| GSM4566453 |
Sample 822 (Lung, Tumor) |
| GSM4566454 |
Sample 853 (Lung, Tumor) |
| GSM4566455 |
Sample 00271 (Lung, Tumor) |
| GSM4566456 |
Sample 00354 (Lung, Tumor) |
| GSM4566457 |
Sample 00363 (Lung, Tumor) |
| GSM4566458 |
Sample 1285 (Lung, Tumor) |
| GSM4566459 |
Sample 359 (Lung, Tumor) |
| GSM4566460 |
Sample 395 (Lung, Tumor) |
| GSM4566461 |
Sample 612 (Lung, Tumor) |
| GSM4566462 |
Sample 618 (Lung, Tumor) |
| GSM4566463 |
Sample 809 (Lung, Tumor) |
| GSM4566464 |
Sample 921 (Lung, Tumor) |
| GSM4566465 |
Sample 931 (Lung, Tumor) |
| GSM4566466 |
Sample 00282 (Lung, Tumor) |
| GSM4566467 |
Sample 202 (Lung, Tumor) |
| GSM4566468 |
Sample 279 (Lung, Tumor) |
| GSM4566469 |
Sample 421 (Lung, Tumor) |
| GSM4566470 |
Sample 627 (Lung, Tumor) |
| GSM4566471 |
Sample 635 (Lung, Tumor) |
| GSM4566472 |
Sample 977 (Lung, Tumor) |
| GSM4566473 |
Sample 00319 (Lung, Normal) |
| GSM4566474 |
Sample 1012 (Lung, Normal) |
| GSM4566475 |
Sample 1022 (Lung, Normal) |
| GSM4566476 |
Sample 1246 (Lung, Normal) |
| GSM4566477 |
Sample 208 (Lung, Normal) |
| GSM4566478 |
Sample 243 (Lung, Normal) |
| GSM4566479 |
Sample 359 (Lung, Normal) |
| GSM4566480 |
Sample 493 (Lung, Normal) |
| GSM4566481 |
Sample 681 (Lung, Normal) |
| GSM4566482 |
Sample 822 (Lung, Normal) |
| GSM4566483 |
Sample 00271 (Lung, Normal) |
| GSM4566484 |
Sample 00354 (Lung, Normal) |
| GSM4566485 |
Sample 00363 (Lung, Normal) |
| GSM4566486 |
Sample 1285 (Lung, Normal) |
| GSM4566487 |
Sample 395 (Lung, Normal) |
| GSM4566488 |
Sample 612 (Lung, Normal) |
| GSM4566489 |
Sample 618 (Lung, Normal) |
| GSM4566490 |
Sample 809 (Lung, Normal) |
| GSM4566491 |
Sample 921 (Lung, Normal) |
| GSM4566492 |
Sample 931 (Lung, Normal) |
| GSM4566493 |
Sample 1286 (Lung, Tumor) |
| GSM4566494 |
Sample 00282 (Lung, Normal) |
| GSM4566495 |
Sample 421 (Lung, Normal) |
| GSM4566496 |
Sample 627 (Lung, Normal) |
| GSM4566497 |
Sample 635 (Lung, Normal) |
| GSM4566498 |
Sample 76 (Lung, Tumor) |
| GSM4566499 |
Sample 977 (Lung, Normal) |
| GSM4566500 |
Sample 00324 (Lung, Tumor) |
| GSM4566501 |
Sample 1274 (Lung, Tumor) |
| GSM4566502 |
Sample 1291 (Lung, Tumor) |
| GSM4566503 |
Sample 1299 (Lung, Tumor) |
| GSM4566504 |
Sample 223 (Lung, Tumor) |
| GSM4566505 |
Sample 24 (Lung, Tumor) |
| GSM4566506 |
Sample 35 (Lung, Tumor) |
| GSM4566507 |
Sample 52 (Lung, Tumor) |
| GSM4566508 |
Sample 688 (Lung, Tumor) |
| GSM4566509 |
Sample 689 (Lung, Tumor) |
| GSM4566510 |
Sample 886 (Lung, Tumor) |
| GSM4566511 |
Sample 969 (Lung, Tumor) |
| GSM4566512 |
Sample 93 (Lung, Tumor) |
| GSM4566513 |
Sample 00355 (Lung, Tumor) |
| GSM4566514 |
Sample 00405 (Lung, Tumor) |
| GSM4566515 |
Sample 00434 (Lung, Tumor) |
| GSM4566516 |
Sample 1002 (Lung, Tumor) |
| GSM4566517 |
Sample 1306 (Lung, Tumor) |
| GSM4566518 |
Sample 202 (Lung, Normal) |
| GSM4566519 |
Sample 617 (Lung, Tumor) |
| GSM4566520 |
Sample 629 (Lung, Tumor) |
| GSM4566521 |
Sample 82 (Lung, Tumor) |
| GSM4566522 |
Sample 934 (Lung, Tumor) |
| GSM4566523 |
Sample 1286 (Lung, Normal) |
| GSM4566524 |
Sample 00301 (Lung, Tumor) |
| GSM4566525 |
Sample 21 (Lung, Tumor) |
| GSM4566526 |
Sample 423 (Lung, Tumor) |
| GSM4566527 |
Sample 642 (Lung, Tumor) |
| GSM4566528 |
Sample 674 (Lung, Tumor) |
| GSM4566529 |
Sample 951 (Lung, Tumor) |
| GSM4566530 |
Sample 1274 (Lung, Normal) |
| GSM4566531 |
Sample 1291 (Lung, Normal) |
| GSM4566532 |
Sample 1299 (Lung, Normal) |
| GSM4566533 |
Sample 223 (Lung, Normal) |
| GSM4566534 |
Sample 24 (Lung, Normal) |
| GSM4566535 |
Sample 35 (Lung, Normal) |
| GSM4566536 |
Sample 52 (Lung, Normal) |
| GSM4566537 |
Sample 688 (Lung, Normal) |
| GSM4566538 |
Sample 689 (Lung, Normal) |
| GSM4566539 |
Sample 886 (Lung, Normal) |
| GSM4566540 |
Sample 969 (Lung, Normal) |
| GSM4566541 |
Sample 00355 (Lung, Normal) |
| GSM4566542 |
Sample 00434 (Lung, Normal) |
| GSM4566543 |
Sample 1002 (Lung, Normal) |
| GSM4566544 |
Sample 1306 (Lung, Normal) |
| GSM4566545 |
Sample 617 (Lung, Normal) |
| GSM4566546 |
Sample 629 (Lung, Normal) |
| GSM4566547 |
Sample 82 (Lung, Normal) |
| GSM4566548 |
Sample 853 (Lung, Normal) |
| GSM4566549 |
Sample 934 (Lung, Normal) |
| GSM4566550 |
Sample 1251 (Lung, Tumor) |
| GSM4566551 |
Sample 00301 (Lung, Normal) |
| GSM4566552 |
Sample 00314 (Lung, Tumor) |
| GSM4566553 |
Sample 21 (Lung, Normal) |
| GSM4566554 |
Sample 423 (Lung, Normal) |
| GSM4566555 |
Sample 642 (Lung, Normal) |
| GSM4566556 |
Sample 674 (Lung, Normal) |
| GSM4566557 |
Sample 951 (Lung, Normal) |
| GSM4566558 |
Sample 1301 (Lung, Tumor) |
| GSM4566559 |
Sample 247 (Lung, Tumor) |
| GSM4566560 |
Sample 469 (Lung, Normal) |
| GSM4566561 |
Sample 480 (Lung, Tumor) |
| GSM4566562 |
Sample 889 (Lung, Tumor) |
| GSM4566563 |
Sample 622 (Lung, Tumor) |
| GSM4566564 |
Sample 00324 (Lung, Normal) |
| GSM4566565 |
Sample 834 (Lung, Tumor) |
| GSM4566566 |
Sample 00405 (Lung, Normal) |
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| This SubSeries is part of SuperSeries: |
| GSE151103 |
Disruption of Y chromosome expression in male lung cancer |
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| Relations |
| BioProject |
PRJNA634683 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE151101_RAW.tar |
1.0 Gb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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