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Series GSE151101 Query DataSets for GSE151101
Status Public on Jun 15, 2021
Title Disruption of Y chromosome expression in male lung cancer: discovery
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Lung cancer is the single most frequent cause of cancer death worldwide and is relatively more common in males. For reasons that are currently unknown, lung cancer is also associated with significantly worse outcomes in men than women. Here we examine the pulmonary transcriptome in lung cancer at a systems level through network analysis. We compare gene expression networks in affected and unaffected tissue derived from 126 patients with lung cancer. Examination of tissue-specific co-expression patterns reveals markedly poor preservation of a sex-associated gene co-expression network in tumor tissue.
Overall design Human whole transcriptome data were generated from pulmonary tumor and, where possible, matched unaffected tissue (referred to hereon as ‘normal’) using the Affymetrix HuGene 1.1 ST microarray, giving a total of 237 samples from 126 patients. Tumor samples and adjacent normal lung tissue were donated from surgical resections, undertaken with curative intent.
Contributor(s) Arseneault M, Cookson WO, Domingo Sabugo C, Freidin MB, Kiong Lu S, Lathrop M, Liang L, Lim E, Moffatt MF, Nicholson AG, Popat S, Riazalhosseini Y, Starren E, Willis-Owen SA, Zhang Y
Citation(s) 34127738
Submission date May 23, 2020
Last update date Nov 16, 2021
Contact name William Cookson
Organization name Imperial College London
Street address Dovehouse Street
City London
ZIP/Postal code SW3 6LY
Country United Kingdom
Platforms (1)
GPL11532 [HuGene-1_1-st] Affymetrix Human Gene 1.1 ST Array [transcript (gene) version]
Samples (237)
GSM4566330 Sample 00304 (Lung, Tumor)
GSM4566331 Sample 00443 (Lung, Tumor)
GSM4566332 Sample 1008 (Lung, Tumor)
This SubSeries is part of SuperSeries:
GSE151103 Disruption of Y chromosome expression in male lung cancer
BioProject PRJNA634683

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE151101_RAW.tar 1.0 Gb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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