Similar studies for GEO DataSets (Select 200218971) - GEO DataSets

Links from GEO DataSets

Items: 20

Select item 2002189711.

Chromosome conformation capture (Hi-C) of the turquoise killifish

(Submitter supplied) This approach was used to increase the continuity of the killifish genome, and assess the relative distance of specific genes from the sex locus.

Organism:: Nothobranchius furzeri

Type:: Other

Platform:: GPL30852
2 Samples

Download data: FASTA, HIC

Series

Accession:: GSE218971

ID:: 200218971

PubMed Similar studies

Select item 2002487412.

The germline regulates longevity and somatic repair in a sex-specific manner

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL33195 GPL30852
51 Samples

Download data: CSV

Series

Accession:: GSE248741

ID:: 200248741

PubMed Similar studies

Select item 2002487393.

The germline regulates longevity and somatic repair in a sex-specific manner (RNA-Seq)

(Submitter supplied) Classical evolutionary theories propose tradeoffs between reproduction, damage repair, and lifespan. However, the specific role of the germline in shaping vertebrate aging remains largely unknown. Here, we use the turquoise killifish (N. furzeri) to genetically arrest germline differentiation at discrete stages, and examine how different ‘flavors’ of infertility impact life-history. We first constructed a comprehensive single-cell gonadal atlas, providing cell-type-specific markers for downstream phenotypic analysis. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL33195
28 Samples

Download data: CSV

Series

Accession:: GSE248739

ID:: 200248739

PubMed Similar studies

Select item 2002186224.

Signals from the reproductive system regulate somatic regeneration and vertebrate lifespan

(Submitter supplied) In many vertebrate species, age at maturity is proportional to organismal lifespan. A number of theories have attempted to provide a conceptual framework for this fascinating apparent co-evolution. The ‘disposable soma’ theory predicts that costly resources that are invested in germline preservation come at the expense of repairing age-related somatic damage. On the other hand, classical experiments in C. more...

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL30852
23 Samples

Download data: CSV

Series

Accession:: GSE218622

ID:: 200218622

PubMed Similar studies

Select item 2000305055.

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans

(Submitter supplied) The plasticity of ageing suggests that longevity may be controlled epigenetically by specific alterations in chromatin state. The link between chromatin and ageing has mostly focused on histone deacetylation by the Sir2 family1, 2, but less is known about the role of other histone modifications in longevity. Histone methylation has a crucial role in development and in maintaining stem cell pluripotency in mammals3. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Datasets:: GDS4575 GDS5012
Platform:: GPL200
23 Samples

Download data: CEL

Series

Accession:: GSE30505

ID:: 200030505

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 50126.

ash-2 knockdown effect on germline-deficient glp-1(e2141ts) mutant: day 8 (mid-life stage)

Analysis of day 8 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL200
Series:: GSE30505
11 Samples

Download data: CEL

DataSet

Accession:: GDS5012

ID:: 5012

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 45757.

ash-2 knockdown effect on germline-deficient glp-1(e2141ts) mutant: day 2 (L3 stage)

Analysis of day 2 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array, transformed count, 2 genotype/variation, 2 protocol sets

Platform:: GPL200
Series:: GSE30505
12 Samples

Download data: CEL

DataSet

Accession:: GDS4575

ID:: 4575

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

Select item 2000447038.

C. elegans gonad-ablated (Z1-,Z4-) animals versus intact animals, N2 strain

(Submitter supplied) Transcriptional profiling of C. elegans germline-ablated worms versus unablated intact animals, N2 strain

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL10094
3 Samples

Download data: GPR

Series

Accession:: GSE44703

ID:: 200044703

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000447029.

C. elegans germline-ablated (Z2-, Z3-) animals versus intact animals, N2 strain

(Submitter supplied) Transcriptional profiling of C. elegans germline-ablated worms versus unablated intact animals, N2 strain

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL10094
3 Samples

Download data: GPR

Series

Accession:: GSE44702

ID:: 200044702

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20012893510.

Endogenous siRNAs promote proteostasis and longevity in germline-less Caenorhabditis elegans

(Submitter supplied) How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in C.CaenorhabditisC. elegans elegans, we reveal an unprecedented role for endo-siRNA molecules in the maintenance of proteostasis and lifespan extension in germline-less animals. more...

Organism:: Caenorhabditis elegans

Type:: Non-coding RNA profiling by high throughput sequencing

Platform:: GPL18245
6 Samples

Download data: XLSX

Series

Accession:: GSE128935

ID:: 200128935

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20012245711.

Endogenous siRNAs Promote Proteostasis and Longevity in Germline-less C. elegans

(Submitter supplied) How lifespan and the rate of aging are set is a key problem in biology. Small RNAs are conserved molecules that impact diverse biological processes through the control of gene expression. However, in contrast to miRNAs, the role of endo-siRNAs in aging remains unexplored. Here, by combining deep sequencing and genomic and genetic approaches in C. elegans, we reveal an unprecedented role for endo-siRNA molecules in the maintenance of proteostasis and lifespan extension in germline-less animals. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL25800
8 Samples

Download data: TXT

Series

Accession:: GSE122457

ID:: 200122457

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20008607712.

LIN-28 balances longevity and germline stem cell number in C. elegans through let-7/AKT/DAF-16 axis

(Submitter supplied) Transcriptomic effects of lin-28 RNAi on N2 and glp-1 worms were compared.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
4 Samples

Download data: DIFF

Series

Accession:: GSE86077

ID:: 200086077

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20005234013.

Expression analysis of C. elegans wild-type N2 and rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutants

(Submitter supplied) Investigation of whole genome gene expression level changes in C. elegans rsks-1, daf-2, daf-2 rsks-1 and daf-16; daf-2 rsks-1 mutant compared to the wild-type N2 strain. The mutants have altered longevity phenotypes. The mutants analyzed in this study are further described in Di Chen, Patrick Wai-Lun Li, Benjamin A. Goldstein, Waijiao Cai, Emma Lynn Thomas, Fen Chen, Alan E. Hubbard, Simon Melov and Pankaj Kapahi, Germline Signaling Mediates the Synergistically Prolonged Longevity by Double Mutations in daf-2 and rsks-1 in C. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by array

Platform:: GPL17925
47 Samples

Download data: PAIR

Series

Accession:: GSE52340

ID:: 200052340

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 20021636914.

An automated feeding system for the African killifish reveals effects of dietary restriction on lifespan and allows scalable assessment of associative learning

(Submitter supplied) To study the effect of dietary restriction on killifish, we generated transcriptomes (RNA-seq) for the livers and brains of male and female killifish that had been subjected to different dietary treatements.

Organism:: Nothobranchius furzeri

Type:: Expression profiling by high throughput sequencing

Platform:: GPL32658
32 Samples

Download data: CSV

Series

Accession:: GSE216369

ID:: 200216369

PubMed Full text in PMC Similar studies

Select item 20022902215.

Single nuclei gene expression profile for adult C. elegans and several longevity mutants

(Submitter supplied) We presents a complete single-cell atlas of aging worms, encompassing both somatic and germ cell types. This atlas was built upon 241K nuclei across the worm lifespan at day 1, 6, 12, and 14 (100%, 99%, 61%, and 14% survival rates, respectively). The worms were aged under normal physiological conditions, without interfering with their reproductive processes.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL26672 GPL32326 GPL27998
28 Samples

Download data: MTX, RDS, TSV

Series

Accession:: GSE229022

ID:: 200229022

PubMed Full text in PMC Similar studies

Select item 20003370016.

Transcriptome analysis of hpl-2(tm1489) vs wild-type worms at mixed embryonic and third larval stages

(Submitter supplied) Epigenetic factors guide cell fate decisions and can stabilize development by buffering environmental variation. HP1 proteins have a well-characterized role in heterochromatin packaging and gene regulation, while their function in organismal development is less well understood. Here we used genome-wide expression profiling to assess novel functions of the C. elegans HP1 homologue HPL-2 at specific developmental stages

Organism:: Caenorhabditis elegans

Type:: Expression profiling by genome tiling array

Platform:: GPL5634
12 Samples

Download data: CDF, CEL, TXT

Series

Accession:: GSE33700

ID:: 200033700

PubMed Full text in PMC Similar studies

Select item 20010884817.

SET-9 and SET-26 are H3K4me3 readers and play critical roles in germline development and longevity

(Submitter supplied) SET-9 and SET-26 are highly homologous paralogs that share redundant function in germline development, but SET-26 alone plays a key role in longevity and heat stress response. SET-26 is broadly expressed, but SET-9 is only detectable in the germline, which likely account for their different biological roles. SET-9 and SET-26 bind to H3K4me3 in vitro and in vivo, and their loss results in broadening of H3K4me3 domains. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL19757
32 Samples

Download data: BEDGRAPH, XLSX

Series

Accession:: GSE108848

ID:: 200108848

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20010062318.

SET-9 and SET-26, the C. elegans homologs of human MLL5, are critical for germline development and longevity

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platforms:: GPL18245 GPL19757
24 Samples

Download data: BEDGRAPH, TXT

Series

Accession:: GSE100623

ID:: 200100623

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20009269019.

Transcriptome profiling of P-granule-depleted or P-granule mutant gonads versus control gonads over time

(Submitter supplied) The germ cells of multicellular organisms protect their developmental potential through specialized mechanisms. A shared feature of germ cells from worms to humans is the presence of non-membrane-bound ribonucleoprotein organelles called germ granules. Depletion of germ granules in Caenorhabditis elegans (i.e., P granules) leads to sterility and in some germlines expression of the neuronal transgene unc-119::gfp and the muscle myosin MYO-3. more...

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL13657 GPL18245 GPL22765
29 Samples

Download data: XLSX

Series

Accession:: GSE92690

ID:: 200092690

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 20011948520.

Polysome profiling and mRNA-seq to quantify translational gene regulation in dietary restricted C. elegans and in a long-lived daf-2:rsks-1 double mutant.

(Submitter supplied) Dietary restriction (DR) and loss of the genes rsks-1 and daf-2 increase longevity in C. elegans. Polysome profiling allows actively translated mRNA bound by multiple ribosomes to be isolated and compared to the total mRNA present. In this project, we differentiate transcriptional and translational changes in gene expression in C. elegans by combining polysome profiling and mRNA-sequencing. By comparing gene abundance between the two RNA pools, genes with altered translational regulation under DR and in the mutant can be identified.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing

Platform:: GPL13657
24 Samples

Download data: TXT

Series

Accession:: GSE119485

ID:: 200119485

PubMed Full text in PMC Similar studies SRA Run Selector

GEO DataSets

Functional Genomics Studies

Result Filters

Entry type

Organism

Study type

Author

Attribute name

Publication dates

Custom date range

Additional filters

Send to:

Links from GEO DataSets

Items: 20

Send to:

Supplemental Content

Find related data

Important Links

Recent activity