ash-2 knockdown effect on germline-deficient glp-1(e2141ts) mutant: day 8 (mid-life stage)
Summary:
Analysis of day 8 germline-deficient glp-1 mutants treated with ash-2 RNAi. The ASH-2 trithorax complex trimethylates histone H3 at lysine 4 (H3K4); an intact germline is required for ASH-2-induced lifespan extension. Results provide insight into the role of histone methylation in longevity.
GPL200:
[Celegans] Affymetrix C. elegans Genome Array
Citation:
Greer EL, Maures TJ, Hauswirth AG, Green EM et al. Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Nature 2010 Jul 15;466(7304):383-7. PMID: 20555324
