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Neoplasm of mature B-cells

MedGen UID:
235305
•Concept ID:
C1334633
•
Neoplastic Process
Synonyms: Mature B-Cell Lymphocytic Neoplasm; mature B-cell lymphocytic neoplasm; Mature B-Cell Neoplasm; mature B-cell neoplasm; mature B-cell neoplasms; neoplasm of mature B-cells
 
Monarch Initiative: MONDO:0004949

Definition

A neoplasm that arises from mature B-lymphocytes or plasma cells. Representative examples include mature B-cell non-Hodgkin lymphomas, chronic lymphocytic leukemia, hairy cell leukemia, plasma cell neoplasms, and B-cell proliferations of uncertain malignant potential. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNeoplasm of mature B-cells

Professional guidelines

PubMed

Hairy cell leukemia 2024: Update on diagnosis, risk-stratification, and treatment-Annual updates in hematological malignancies.
Troussard X, Maître E, Paillassa J
Am J Hematol 2024 Apr;99(4):679-696. Epub 2024 Mar 5 doi: 10.1002/ajh.27240. PMID: 38440808
CAR T-Cell therapy for the management of mantle cell lymphoma.
Huang Z, Chavda VP, Bezbaruah R, Dhamne H, Yang DH, Zhao HB
Mol Cancer 2023 Mar 31;22(1):67. doi: 10.1186/s12943-023-01755-5. PMID: 37004047Free PMC Article
Chronic lymphocytic leukaemia: from genetics to treatment.
Bosch F, Dalla-Favera R
Nat Rev Clin Oncol 2019 Nov;16(11):684-701. doi: 10.1038/s41571-019-0239-8. PMID: 31278397

Recent clinical studies

Etiology

Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Role of Bruton's tyrosine kinase in B cells and malignancies.
Pal Singh S, Dammeijer F, Hendriks RW
Mol Cancer 2018 Feb 19;17(1):57. doi: 10.1186/s12943-018-0779-z. PMID: 29455639Free PMC Article
Chronic lymphocytic leukaemia.
Kipps TJ, Stevenson FK, Wu CJ, Croce CM, Packham G, Wierda WG, O'Brien S, Gribben J, Rai K
Nat Rev Dis Primers 2017 Jan 19;3:16096. doi: 10.1038/nrdp.2016.96. PMID: 28102226Free PMC Article
Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174

Diagnosis

Spatial immunophenotyping of the tumour microenvironment in non-small cell lung cancer.
Backman M, Strell C, Lindberg A, Mattsson JSM, Elfving H, Brunnström H, O'Reilly A, Bosic M, Gulyas M, Isaksson J, Botling J, Kärre K, Jirström K, Lamberg K, Pontén F, Leandersson K, Mezheyeuski A, Micke P
Eur J Cancer 2023 May;185:40-52. Epub 2023 Feb 24 doi: 10.1016/j.ejca.2023.02.012. PMID: 36963351
Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches.
Shah N, Chari A, Scott E, Mezzi K, Usmani SZ
Leukemia 2020 Apr;34(4):985-1005. Epub 2020 Feb 13 doi: 10.1038/s41375-020-0734-z. PMID: 32055000Free PMC Article
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Lymphoblastic lymphoma.
Cortelazzo S, Ferreri A, Hoelzer D, Ponzoni M
Crit Rev Oncol Hematol 2017 May;113:304-317. Epub 2017 Mar 18 doi: 10.1016/j.critrevonc.2017.03.020. PMID: 28427520

Therapy

Mature tertiary lymphoid structures are key niches of tumour-specific immune responses in pancreatic ductal adenocarcinomas.
Kinker GS, Vitiello GAF, Diniz AB, Cabral-Piccin MP, Pereira PHB, Carvalho MLR, Ferreira WAS, Chaves AS, Rondinelli A, Gusmão AF, Defelicibus A, Dos Santos GO, Nunes WA, Claro LCL, Bernardo TM, Nishio RT, Pacheco AM, Laus AC, Arantes LMRB, Fleck JL, de Jesus VHF, de Moricz A, Weinlich R, Coimbra FJF, de Lima VCC, Medina TDS
Gut 2023 Oct;72(10):1927-1941. Epub 2023 May 25 doi: 10.1136/gutjnl-2022-328697. PMID: 37230755
BCMA-targeted immunotherapy for multiple myeloma.
Yu B, Jiang T, Liu D
J Hematol Oncol 2020 Sep 17;13(1):125. doi: 10.1186/s13045-020-00962-7. PMID: 32943087Free PMC Article
B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches.
Shah N, Chari A, Scott E, Mezzi K, Usmani SZ
Leukemia 2020 Apr;34(4):985-1005. Epub 2020 Feb 13 doi: 10.1038/s41375-020-0734-z. PMID: 32055000Free PMC Article
Follicular lymphoma.
Carbone A, Roulland S, Gloghini A, Younes A, von Keudell G, López-Guillermo A, Fitzgibbon J
Nat Rev Dis Primers 2019 Dec 12;5(1):83. doi: 10.1038/s41572-019-0132-x. PMID: 31831752
Role of Bruton's tyrosine kinase in B cells and malignancies.
Pal Singh S, Dammeijer F, Hendriks RW
Mol Cancer 2018 Feb 19;17(1):57. doi: 10.1186/s12943-018-0779-z. PMID: 29455639Free PMC Article

Prognosis

Plasma cell neoplasms and related entities-evolution in diagnosis and classification.
Fend F, Dogan A, Cook JR
Virchows Arch 2023 Jan;482(1):163-177. Epub 2022 Nov 21 doi: 10.1007/s00428-022-03431-3. PMID: 36414803Free PMC Article
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome.
Fridman WH, Meylan M, Petitprez F, Sun CM, Italiano A, Sautès-Fridman C
Nat Rev Clin Oncol 2022 Jul;19(7):441-457. Epub 2022 Apr 1 doi: 10.1038/s41571-022-00619-z. PMID: 35365796
B Cell Lymphoma.
Meng X, Min Q, Wang JY
Adv Exp Med Biol 2020;1254:161-181. doi: 10.1007/978-981-15-3532-1_12. PMID: 32323276
Human memory B cells.
Seifert M, Küppers R
Leukemia 2016 Dec;30(12):2283-2292. Epub 2016 Aug 8 doi: 10.1038/leu.2016.226. PMID: 27499139
Chronic lymphocytic leukaemia.
Scarfò L, Ferreri AJ, Ghia P
Crit Rev Oncol Hematol 2016 Aug;104:169-82. Epub 2016 Jun 16 doi: 10.1016/j.critrevonc.2016.06.003. PMID: 27370174

Clinical prediction guides

Tertiary lymphoid structural heterogeneity determines tumour immunity and prospects for clinical application.
Zhang Y, Xu M, Ren Y, Ba Y, Liu S, Zuo A, Xu H, Weng S, Han X, Liu Z
Mol Cancer 2024 Apr 6;23(1):75. doi: 10.1186/s12943-024-01980-6. PMID: 38582847Free PMC Article
Characterization of intratumoral tertiary lymphoid structures in pancreatic ductal adenocarcinoma: cellular properties and prognostic significance.
Zou X, Lin X, Cheng H, Chen Y, Wang R, Ma M, Liu Y, Dai Z, Tasiheng Y, Yan Y, Hou Q, Ding F, Chen H, Yu X, Wang X, Liu C
J Immunother Cancer 2023 Jun;11(6) doi: 10.1136/jitc-2023-006698. PMID: 37364934Free PMC Article
B cells and tertiary lymphoid structures as determinants of tumour immune contexture and clinical outcome.
Fridman WH, Meylan M, Petitprez F, Sun CM, Italiano A, Sautès-Fridman C
Nat Rev Clin Oncol 2022 Jul;19(7):441-457. Epub 2022 Apr 1 doi: 10.1038/s41571-022-00619-z. PMID: 35365796
B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?
Lauss M, Donia M, Svane IM, Jönsson G
Clin Cancer Res 2022 May 2;28(9):1751-1758. doi: 10.1158/1078-0432.CCR-21-1130. PMID: 34965949Free PMC Article
B-cell maturation antigen (BCMA) in multiple myeloma: rationale for targeting and current therapeutic approaches.
Shah N, Chari A, Scott E, Mezzi K, Usmani SZ
Leukemia 2020 Apr;34(4):985-1005. Epub 2020 Feb 13 doi: 10.1038/s41375-020-0734-z. PMID: 32055000Free PMC Article

Recent systematic reviews

Is acute lymphoblastic leukemia with mature B-cell phenotype and KMT2A rearrangements a new entity? A systematic review and meta-analysis.
Hidalgo-Gómez G, Palacio-Garcia C, Gallur L, Blanco A, Tazón-Vega B, Saumell S, Martínez N, Murillo L, Murciano T, Velasco P, Bosch F, Diaz-Heredia C, Ortega M
Leuk Lymphoma 2021 Sep;62(9):2202-2210. Epub 2021 Apr 7 doi: 10.1080/10428194.2021.1907375. PMID: 33827367
CD43 in the malignant flow cytometry laboratory in 2020.
Sorigue M
Expert Rev Hematol 2021 Jan;14(1):123-136. Epub 2021 Jan 11 doi: 10.1080/17474086.2021.1856653. PMID: 33249940

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