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Adult Burkitt Leukemia

MedGen UID:
75998
•Concept ID:
C0279591
•
Neoplastic Process
Synonym: Adult Burkitt's Leukemia

Definition

The leukemic counterpart of Burkitt lymphoma occurring in adults. The characteristic Burkitt cells are seen in the bone marrow and the peripheral blood. This is an aggressive leukemia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdult Burkitt Leukemia

Professional guidelines

PubMed

The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Treatment of relapsed/refractory paediatric aggressive B-cell non-Hodgkin lymphoma.
Moleti ML, Testi AM, Foà R
Br J Haematol 2020 Jun;189(5):826-843. Epub 2020 Mar 6 doi: 10.1111/bjh.16461. PMID: 32141616
Management of adults with Burkitt lymphoma.
Gastwirt JP, Roschewski M
Clin Adv Hematol Oncol 2018 Dec;16(12):812-822. PMID: 30843890

Recent clinical studies

Therapy

The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947
Chemoimmunotherapy with hyper-CVAD plus rituximab for the treatment of adult Burkitt and Burkitt-type lymphoma or acute lymphoblastic leukemia.
Thomas DA, Faderl S, O'Brien S, Bueso-Ramos C, Cortes J, Garcia-Manero G, Giles FJ, Verstovsek S, Wierda WG, Pierce SA, Shan J, Brandt M, Hagemeister FB, Keating MJ, Cabanillas F, Kantarjian H
Cancer 2006 Apr 1;106(7):1569-80. doi: 10.1002/cncr.21776. PMID: 16502413
Modified magrath regimens for adults with Burkitt and Burkitt-like lymphomas: preserved efficacy with decreased toxicity.
Lacasce A, Howard O, Lib S, Fisher D, Weng A, Neuberg D, Shipp M
Leuk Lymphoma 2004 Apr;45(4):761-7. doi: 10.1080/1042819031000141301. PMID: 15160953

Prognosis

Emerging entities: high-grade/large B-cell lymphoma with 11q aberration, large B-cell lymphoma with IRF4 rearrangement, and new molecular subgroups in large B-cell lymphomas. A report of the 2022 EA4HP/SH lymphoma workshop.
Quintanilla-Martinez L, Laurent C, Soma L, Ng SB, Climent F, Ondrejka SL, Zamo A, Wotherspoon A, de Leval L, Dirnhofer S, Leoncini L
Virchows Arch 2023 Sep;483(3):281-298. Epub 2023 Aug 9 doi: 10.1007/s00428-023-03590-x. PMID: 37555980Free PMC Article
The treatment of Burkitt lymphoma in adults.
Crombie J, LaCasce A
Blood 2021 Feb 11;137(6):743-750. doi: 10.1182/blood.2019004099. PMID: 33171490
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Burkitt's lymphoma.
Molyneux EM, Rochford R, Griffin B, Newton R, Jackson G, Menon G, Harrison CJ, Israels T, Bailey S
Lancet 2012 Mar 31;379(9822):1234-44. Epub 2012 Feb 13 doi: 10.1016/S0140-6736(11)61177-X. PMID: 22333947
Burkitt lymphoma/leukemia: improving prognosis.
Kenkre VP, Stock W
Clin Lymphoma Myeloma 2009;9 Suppl 3:S231-8. doi: 10.3816/CLM.2009.s.017. PMID: 19778846

Clinical prediction guides

Prediction of severe CRS and determination of biomarkers in B cell-acute lymphoblastic leukemia treated with CAR-T cells.
Wei Z, Xu J, Zhao C, Zhang M, Xu N, Kang L, Lou X, Yu L, Feng W
Front Immunol 2023;14:1273507. Epub 2023 Oct 3 doi: 10.3389/fimmu.2023.1273507. PMID: 37854590Free PMC Article
Estimating the global burden of Epstein-Barr virus-related cancers.
Wong Y, Meehan MT, Burrows SR, Doolan DL, Miles JJ
J Cancer Res Clin Oncol 2022 Jan;148(1):31-46. Epub 2021 Oct 27 doi: 10.1007/s00432-021-03824-y. PMID: 34705104Free PMC Article
Multicenter Study of Risk-Adapted Therapy With Dose-Adjusted EPOCH-R in Adults With Untreated Burkitt Lymphoma.
Roschewski M, Dunleavy K, Abramson JS, Powell BL, Link BK, Patel P, Bierman PJ, Jagadeesh D, Mitsuyasu RT, Peace D, Watson PR, Hanna WT, Melani C, Lucas AN, Steinberg SM, Pittaluga S, Jaffe ES, Friedberg JW, Kahl BS, Little RF, Bartlett NL, Fanale MA, Noy A, Wilson WH
J Clin Oncol 2020 Aug 1;38(22):2519-2529. Epub 2020 May 26 doi: 10.1200/JCO.20.00303. PMID: 32453640Free PMC Article
Low-intensity therapy in adults with Burkitt's lymphoma.
Dunleavy K, Pittaluga S, Shovlin M, Steinberg SM, Cole D, Grant C, Widemann B, Staudt LM, Jaffe ES, Little RF, Wilson WH
N Engl J Med 2013 Nov 14;369(20):1915-25. doi: 10.1056/NEJMoa1308392. PMID: 24224624Free PMC Article
Burkitt's and Burkitt-like lymphoma.
Evens AM, Gordon LI
Curr Treat Options Oncol 2002 Aug;3(4):291-305. doi: 10.1007/s11864-002-0029-9. PMID: 12074766

Recent systematic reviews

EFFICACY OF AUTOLOGOUS STEM CELL TRANSPLANTATION IN ADULT BURKITT/BURKITT-LIKE LYMPHOMA: A SYSTEMATIC REVIEW.
Joshi U, Subedi R, Nepal G, Gyawali S, Agrawal V, Poudyal BS, Bhatt VR, D'Angelo CR
Exp Oncol 2022 Nov;44(3):190-197. doi: 10.32471/exp-oncology.2312-8852.vol-44-no-3.18599. PMID: 36325697
Burkitt and Burkitt-Like Lymphomas: a Systematic Review.
Saleh K, Michot JM, Camara-Clayette V, Vassetsky Y, Ribrag V
Curr Oncol Rep 2020 Mar 6;22(4):33. doi: 10.1007/s11912-020-0898-8. PMID: 32144513
Effect of rituximab on adult Burkitt's lymphoma: a systematic review and meta-analysis.
Nie M, Wang Y, Bi XW, Xia Y, Sun P, Liu PP, Li ZM, Jiang WQ
Ann Hematol 2016 Jan;95(1):19-26. Epub 2015 Oct 1 doi: 10.1007/s00277-015-2501-1. PMID: 26423805
Changes in the influence of lymphoma- and HIV-specific factors on outcomes in AIDS-related non-Hodgkin lymphoma.
Barta SK, Samuel MS, Xue X, Wang D, Lee JY, Mounier N, Ribera JM, Spina M, Tirelli U, Weiss R, Galicier L, Boue F, Little RF, Dunleavy K, Wilson WH, Wyen C, Remick SC, Kaplan LD, Ratner L, Noy A, Sparano JA
Ann Oncol 2015 May;26(5):958-966. Epub 2015 Jan 28 doi: 10.1093/annonc/mdv036. PMID: 25632071Free PMC Article
Therapeutic interventions for Burkitt's lymphoma in children.
Okebe JU, Lasserson TJ, Meremikwu MM, Richards S
Cochrane Database Syst Rev 2006 Oct 18;(4):CD005198. doi: 10.1002/14651858.CD005198.pub2. PMID: 17054245

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