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Grade 2 Cutaneous Follicular Lymphoma

MedGen UID:
232246
•Concept ID:
C1333836
•
Neoplastic Process

Definition

A cutaneous lymphoma which contains 6-15 centroblasts per 40X high-power microscopic field. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVGrade 2 Cutaneous Follicular Lymphoma

Professional guidelines

PubMed

Management of Adverse Events From the Combination of Rituximab and Lenalidomide in the Treatment of Patients With Follicular and Low-Grade Non-Hodgkin Lymphoma.
Cheson BD, Morschhauser F, Martin P
Clin Lymphoma Myeloma Leuk 2020 Sep;20(9):563-571. Epub 2020 Mar 20 doi: 10.1016/j.clml.2020.03.009. PMID: 32303486
Single centre study of using bendamustine in the treatment of B-cell malignancies.
Osmani AH, Masood N
J Pak Med Assoc 2013 Jun;63(6):702-6. PMID: 23901668

Recent clinical studies

Therapy

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Aggressive primary scalp lymphoma mimicking an acute epidural hematoma: Case report and review of the literature.
Thibault C, Chibbaro S, Ganau M, Nicolae A, Todeschi J, Mallereau CH
Neurochirurgie 2022 Oct;68(5):e34-e39. Epub 2022 Apr 25 doi: 10.1016/j.neuchi.2022.03.005. PMID: 35477013
Management of Adverse Events From the Combination of Rituximab and Lenalidomide in the Treatment of Patients With Follicular and Low-Grade Non-Hodgkin Lymphoma.
Cheson BD, Morschhauser F, Martin P
Clin Lymphoma Myeloma Leuk 2020 Sep;20(9):563-571. Epub 2020 Mar 20 doi: 10.1016/j.clml.2020.03.009. PMID: 32303486
AUGMENT: A Phase III Study of Lenalidomide Plus Rituximab Versus Placebo Plus Rituximab in Relapsed or Refractory Indolent Lymphoma.
Leonard JP, Trneny M, Izutsu K, Fowler NH, Hong X, Zhu J, Zhang H, Offner F, Scheliga A, Nowakowski GS, Pinto A, Re F, Fogliatto LM, Scheinberg P, Flinn IW, Moreira C, Cabeçadas J, Liu D, Kalambakas S, Fustier P, Wu C, Gribben JG; AUGMENT Trial Investigators
J Clin Oncol 2019 May 10;37(14):1188-1199. Epub 2019 Mar 21 doi: 10.1200/JCO.19.00010. PMID: 30897038Free PMC Article
Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma.
Morschhauser F, Fowler NH, Feugier P, Bouabdallah R, Tilly H, Palomba ML, Fruchart C, Libby EN, Casasnovas RO, Flinn IW, Haioun C, Maisonneuve H, Ysebaert L, Bartlett NL, Bouabdallah K, Brice P, Ribrag V, Daguindau N, Le Gouill S, Pica GM, Martin Garcia-Sancho A, López-Guillermo A, Larouche JF, Ando K, Gomes da Silva M, André M, Zachée P, Sehn LH, Tobinai K, Cartron G, Liu D, Wang J, Xerri L, Salles GA; RELEVANCE Trial Investigators
N Engl J Med 2018 Sep 6;379(10):934-947. doi: 10.1056/NEJMoa1805104. PMID: 30184451Free PMC Article

Prognosis

UCART19, a first-in-class allogeneic anti-CD19 chimeric antigen receptor T-cell therapy for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia (CALM): a phase 1, dose-escalation trial.
Benjamin R, Jain N, Maus MV, Boissel N, Graham C, Jozwik A, Yallop D, Konopleva M, Frigault MJ, Teshima T, Kato K, Boucaud F, Balandraud S, Gianella-Borradori A, Binlich F, Marchiq I, Dupouy S, Almena-Carrasco M, Pannaux M, Fouliard S, Brissot E, Mohty M; CALM Study Group
Lancet Haematol 2022 Nov;9(11):e833-e843. Epub 2022 Oct 10 doi: 10.1016/S2352-3026(22)00245-9. PMID: 36228643
Management of Adverse Events From the Combination of Rituximab and Lenalidomide in the Treatment of Patients With Follicular and Low-Grade Non-Hodgkin Lymphoma.
Cheson BD, Morschhauser F, Martin P
Clin Lymphoma Myeloma Leuk 2020 Sep;20(9):563-571. Epub 2020 Mar 20 doi: 10.1016/j.clml.2020.03.009. PMID: 32303486
De-escalated radiotherapy for indolent primary cutaneous B-cell lymphoma.
Oertel M, Elsayad K, Weishaupt C, Steinbrink K, Eich HT
Strahlenther Onkol 2020 Feb;196(2):126-131. Epub 2019 Nov 22 doi: 10.1007/s00066-019-01541-7. PMID: 31758232
Rituximab plus Lenalidomide in Advanced Untreated Follicular Lymphoma.
Morschhauser F, Fowler NH, Feugier P, Bouabdallah R, Tilly H, Palomba ML, Fruchart C, Libby EN, Casasnovas RO, Flinn IW, Haioun C, Maisonneuve H, Ysebaert L, Bartlett NL, Bouabdallah K, Brice P, Ribrag V, Daguindau N, Le Gouill S, Pica GM, Martin Garcia-Sancho A, López-Guillermo A, Larouche JF, Ando K, Gomes da Silva M, André M, Zachée P, Sehn LH, Tobinai K, Cartron G, Liu D, Wang J, Xerri L, Salles GA; RELEVANCE Trial Investigators
N Engl J Med 2018 Sep 6;379(10):934-947. doi: 10.1056/NEJMoa1805104. PMID: 30184451Free PMC Article
Composite Small Lymphocytic Lymphoma/Chronic Lymphocytic Leukemia and Follicular Lymphoma: A Clinicopathological Study of Six Cases.
Jelloul FZ, Chen QH, Yang T, Haghi N, Brody J, Zhang X, Sheikh-Fayyaz S
Int J Surg Pathol 2018 Apr;26(2):135-144. Epub 2017 Oct 26 doi: 10.1177/1066896917737161. PMID: 29069998

Clinical prediction guides

Management of Adverse Events From the Combination of Rituximab and Lenalidomide in the Treatment of Patients With Follicular and Low-Grade Non-Hodgkin Lymphoma.
Cheson BD, Morschhauser F, Martin P
Clin Lymphoma Myeloma Leuk 2020 Sep;20(9):563-571. Epub 2020 Mar 20 doi: 10.1016/j.clml.2020.03.009. PMID: 32303486
Systemic eight-cycle anti-CD20 monoclonal antibody (rituximab) therapy in primary cutaneous B-cell lymphomas--an applicational observation.
Gellrich S, Muche JM, Wilks A, Jasch KC, Voit C, Fischer T, Audring H, Sterry W
Br J Dermatol 2005 Jul;153(1):167-73. doi: 10.1111/j.1365-2133.2005.06659.x. PMID: 16029344
Clinicopathologic, immunophenotypic, and molecular cytogenetic fluorescence in situ hybridization analysis of primary and secondary cutaneous follicular lymphomas.
Kim BK, Surti U, Pandya A, Cohen J, Rabkin MS, Swerdlow SH
Am J Surg Pathol 2005 Jan;29(1):69-82. doi: 10.1097/01.pas.0000146015.22624.c7. PMID: 15613857
Clusterin expression in malignant lymphomas: a survey of 266 cases.
Saffer H, Wahed A, Rassidakis GZ, Medeiros LJ
Mod Pathol 2002 Nov;15(11):1221-6. doi: 10.1097/01.MP.0000036386.87517.AA. PMID: 12429802
DAB(389)IL-2 (denileukin diftitox, ONTAK): other potential applications.
LeMaistre CF
Clin Lymphoma 2000 Nov;1 Suppl 1:S37-40. PMID: 11707862

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