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Gallbladder carcinoma

MedGen UID:
116001
Concept ID:
C0235782
Neoplastic Process
Synonym: Carcinoma of gallbladder
SNOMED CT: Carcinoma of gallbladder (372140005)
 
Monarch Initiative: MONDO:0003220

Definition

A malignant tumor arising from the epithelium of the gallbladder. It is usually associated with the presence of gallstones. Clinical symptoms are not specific and usually present late in the course. Morphologically, most gallbladder carcinomas are adenocarcinomas; squamous cell carcinomas, adenosquamous carcinomas, signet ring carcinomas, and undifferentiated carcinomas can also occur. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • Gallbladder carcinoma
Follow this link to review classifications for Gallbladder carcinoma in Orphanet.

Professional guidelines

PubMed

Roth GS, Verlingue L, Sarabi M, Blanc JF, Boleslawski E, Boudjema K, Bretagne-Bignon AL, Camus-Duboc M, Coriat R, Créhange G, De Baere T, de la Fouchardière C, Dromain C, Edeline J, Gelli M, Guiu B, Horn S, Laurent-Croise V, Lepage C, Lièvre A, Lopez A, Manfredi S, Meilleroux J, Neuzillet C, Paradis V, Prat F, Ronot M, Rosmorduc O, Cunha AS, Soubrane O, Turpin A, Louvet C, Bouché O, Malka D
Eur J Cancer 2024 May;202:114000. Epub 2024 Mar 13 doi: 10.1016/j.ejca.2024.114000. PMID: 38493667
Giudicelli X, Rode A, Bancel B, Nguyen AT, Mabrut JY
J Visc Surg 2021 Aug;158(4):326-336. Epub 2021 Mar 23 doi: 10.1016/j.jviscsurg.2021.02.004. PMID: 33741306
Shukla SK, Singh G, Shahi KS, Bhuvan, Pant P
J Gastrointest Cancer 2018 Mar;49(1):9-15. doi: 10.1007/s12029-017-0036-5. PMID: 29234972

Recent clinical studies

Etiology

Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M
Hepatology 2021 Jan;73 Suppl 1:128-136. Epub 2020 Nov 26 doi: 10.1002/hep.31325. PMID: 32438491
Gamboa AC, Maithel SK
Ann Surg Oncol 2020 Aug;27(8):2846-2858. Epub 2020 May 30 doi: 10.1245/s10434-020-08654-9. PMID: 32474816
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
Goetze TO
World J Gastroenterol 2015 Nov 21;21(43):12211-7. doi: 10.3748/wjg.v21.i43.12211. PMID: 26604631Free PMC Article

Diagnosis

Marcinak CT, Abbott DE
Cancer Treat Res 2024;192:147-163. doi: 10.1007/978-3-031-61238-1_8. PMID: 39212920
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Gunasekaran G, Bekki Y, Lourdusamy V, Schwartz M
Hepatology 2021 Jan;73 Suppl 1:128-136. Epub 2020 Nov 26 doi: 10.1002/hep.31325. PMID: 32438491
Goetze TO
World J Gastroenterol 2015 Nov 21;21(43):12211-7. doi: 10.3748/wjg.v21.i43.12211. PMID: 26604631Free PMC Article
Pu JJ, Wu W
BMJ Case Rep 2011 Apr 1;2011 doi: 10.1136/bcr.05.2010.3009. PMID: 22700610Free PMC Article

Therapy

Nakachi K, Ikeda M, Konishi M, Nomura S, Katayama H, Kataoka T, Todaka A, Yanagimoto H, Morinaga S, Kobayashi S, Shimada K, Takahashi Y, Nakagohri T, Gotoh K, Kamata K, Shimizu Y, Ueno M, Ishii H, Okusaka T, Furuse J; Hepatobiliary and Pancreatic Oncology Group of the Japan Clinical Oncology Group (JCOG-HBPOG)
Lancet 2023 Jan 21;401(10372):195-203. doi: 10.1016/S0140-6736(22)02038-4. PMID: 36681415
Zhang Y, Zuo C, Liu L, Hu Y, Yang B, Qiu S, Li Y, Cao D, Ju Z, Ge J, Wang Q, Wang T, Bai L, Yang Y, Li G, Shao Z, Gao Y, Li Y, Bian R, Miao H, Li L, Li X, Jiang C, Yan S, Wang Z, Wang Z, Cui X, Huang W, Xiang D, Wang C, Li Q, Wu X, Gong W, Liu Y, Shao R, Liu F, Li M, Chen L, Liu Y
J Hepatol 2021 Nov;75(5):1128-1141. Epub 2021 Jun 23 doi: 10.1016/j.jhep.2021.06.023. PMID: 34171432
Gamboa AC, Maithel SK
Ann Surg Oncol 2020 Aug;27(8):2846-2858. Epub 2020 May 30 doi: 10.1245/s10434-020-08654-9. PMID: 32474816
Ashai N, Prasad P, Rajdev L
Curr Treat Options Oncol 2019 May 29;20(7):58. doi: 10.1007/s11864-019-0655-0. PMID: 31144050
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article

Prognosis

Roth GS, Verlingue L, Sarabi M, Blanc JF, Boleslawski E, Boudjema K, Bretagne-Bignon AL, Camus-Duboc M, Coriat R, Créhange G, De Baere T, de la Fouchardière C, Dromain C, Edeline J, Gelli M, Guiu B, Horn S, Laurent-Croise V, Lepage C, Lièvre A, Lopez A, Manfredi S, Meilleroux J, Neuzillet C, Paradis V, Prat F, Ronot M, Rosmorduc O, Cunha AS, Soubrane O, Turpin A, Louvet C, Bouché O, Malka D
Eur J Cancer 2024 May;202:114000. Epub 2024 Mar 13 doi: 10.1016/j.ejca.2024.114000. PMID: 38493667
Ganeshan D, Kambadakone A, Nikolaidis P, Subbiah V, Subbiah IM, Devine C
Abdom Radiol (NY) 2021 Jun;46(6):2474-2489. Epub 2021 Jan 2 doi: 10.1007/s00261-020-02871-2. PMID: 33386907
Goetze TO
World J Gastroenterol 2015 Nov 21;21(43):12211-7. doi: 10.3748/wjg.v21.i43.12211. PMID: 26604631Free PMC Article
Ben-Josef E, Guthrie KA, El-Khoueiry AB, Corless CL, Zalupski MM, Lowy AM, Thomas CR Jr, Alberts SR, Dawson LA, Micetich KC, Thomas MB, Siegel AB, Blanke CD
J Clin Oncol 2015 Aug 20;33(24):2617-22. Epub 2015 May 11 doi: 10.1200/JCO.2014.60.2219. PMID: 25964250Free PMC Article
Pu JJ, Wu W
BMJ Case Rep 2011 Apr 1;2011 doi: 10.1136/bcr.05.2010.3009. PMID: 22700610Free PMC Article

Clinical prediction guides

Shao H, Zhu J, Zhu Y, Liu L, Zhao S, Kang Q, Liu Y, Zou H
BMC Med Genomics 2023 Oct 11;16(1):240. doi: 10.1186/s12920-023-01663-z. PMID: 37821907Free PMC Article
Fang J, Fang F, Huang J, Zhang X, Wang H
Cell Mol Biol (Noisy-le-grand) 2022 Aug 31;68(8):64-68. doi: 10.14715/cmb/2022.68.8.11. PMID: 36800835
Ilyas FZ, Beane JD, Pawlik TM
Cells 2021 Aug 15;10(8) doi: 10.3390/cells10082096. PMID: 34440865Free PMC Article
Zhang Y, Zuo C, Liu L, Hu Y, Yang B, Qiu S, Li Y, Cao D, Ju Z, Ge J, Wang Q, Wang T, Bai L, Yang Y, Li G, Shao Z, Gao Y, Li Y, Bian R, Miao H, Li L, Li X, Jiang C, Yan S, Wang Z, Wang Z, Cui X, Huang W, Xiang D, Wang C, Li Q, Wu X, Gong W, Liu Y, Shao R, Liu F, Li M, Chen L, Liu Y
J Hepatol 2021 Nov;75(5):1128-1141. Epub 2021 Jun 23 doi: 10.1016/j.jhep.2021.06.023. PMID: 34171432
Morel P, Buchs NC, Iranmanesh P, Pugin F, Buehler L, Azagury DE, Jung M, Volonte F, Hagen ME
J Hepatobiliary Pancreat Sci 2014 Jan;21(1):18-25. Epub 2013 Oct 21 doi: 10.1002/jhbp.36. PMID: 24142898

Recent systematic reviews

Lv TR, Wang JK, Li FY, Hu HJ
Int J Surg 2024 Jul 1;110(7):4342-4355. doi: 10.1097/JS9.0000000000001403. PMID: 38537060Free PMC Article
Liu R, Qiu Z, Zhang L, Ma W, Zi L, Wang K, Kuang T, Zhao K, Wang W
J Cachexia Sarcopenia Muscle 2023 Dec;14(6):2509-2519. Epub 2023 Nov 22 doi: 10.1002/jcsm.13371. PMID: 37990969Free PMC Article
Ahmed SH, Usmani SUR, Mushtaq R, Samad S, Abid M, Moeed A, Atif AR, Farhan SA, Saif A
Am J Surg 2023 Jun;225(6):975-987. Epub 2023 Jan 11 doi: 10.1016/j.amjsurg.2023.01.008. PMID: 36693774
Luvira V, Satitkarnmanee E, Pugkhem A, Kietpeerakool C, Lumbiganon P, Pattanittum P
Cochrane Database Syst Rev 2021 Sep 13;9(9):CD012814. doi: 10.1002/14651858.CD012814.pub2. PMID: 34515993Free PMC Article
Lv TR, Yang C, Regmi P, Ma WJ, Hu HJ, Liu F, Yin CH, Jin YW, Li FY
Asian J Surg 2021 Dec;44(12):1493-1502. Epub 2021 Apr 22 doi: 10.1016/j.asjsur.2021.03.015. PMID: 33895048

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